Strain differences in consumption of saline solutions by mice.

Abstract:

:Intake of saline (NaCl) solutions and water by males of two inbred strains of mice [C57BL/6J (C57) and 129/J] were examined using 48-h, two-bottle preference tests. There was a large strain difference in saline intake: at moderate concentrations (0.075-0.150 M) C57 mice tended to reject saline relative to water, whereas 129/J mice preferred it. Both strains of mice increased their intake of saline following lasix-induced sodium depletion and the preference exhibited by 129/J mice for 0.15 M NaCl was eliminated following LiCl toxicosis. The rejection of moderate concentrations of saline by C57 was shown to be due, in part at least, to prior exposure to iso- or hypertonic saline solutions: C57 mice that had no prior exposure to saline exhibited a greater intake of saline than C57 mice previously exposed to 0.30 M NaCl. Saline preferences of the 129/J mice were not affected by prior exposure to 0.30 M NaCl. Thus, the strain difference in mouse salt preference is due in part to postingestional consequences of saline consumption in C57 but not 129/J mice.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Beauchamp GK,Fisher AS

doi

10.1016/0031-9384(93)90063-l

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

179-84

issue

1

eissn

0031-9384

issn

1873-507X

pii

0031-9384(93)90063-L

journal_volume

54

pub_type

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