Abstract:
:Long-term exposure to stress and its physiological mediators, in particular cortisol, may lead to impaired telomere maintenance. In this study, we examine if greater cortisol responses to an acute stressor and/or dysregulated patterns of daily cortisol secretion are associated with shorter telomere length. Twenty-three postmenopausal women comprising caregivers for dementia partners (n=14) and age- and BMI-matched non-caregivers provided home sampling of cortisol-saliva samples at waking, 30 min after waking, and bedtime, and a 12-hour overnight urine collection. They were also exposed to an acute laboratory stressor throughout which they provided saliva samples. Peripheral blood mononuclear cells were isolated from a fasting blood sample and assayed for telomere length. As hypothesized, greater cortisol responses to the acute stressor were associated with shorter telomeres, as were higher overnight urinary free cortisol levels and flatter daytime cortisol slopes. While robust physiological responses to acute stress serve important functions, the long-term consequences of frequent high stress reactivity may include accelerated telomere shortening.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Tomiyama AJ,O'Donovan A,Lin J,Puterman E,Lazaro A,Chan J,Dhabhar FS,Wolkowitz O,Kirschbaum C,Blackburn E,Epel Edoi
10.1016/j.physbeh.2011.11.016subject
Has Abstractpub_date
2012-04-12 00:00:00pages
40-5issue
1eissn
0031-9384issn
1873-507Xpii
S0031-9384(11)00536-1journal_volume
106pub_type
杂志文章abstract::The taste reactivity (TR) test was devised as a method to obtain behavioural data in response to gustatory stimuli in neurologically impaired rats, incapable of voluntary feeding. Sapid solutions were infused through surgically implanted intraoral cannulae. Facial and motor responses corresponded well to known hedonic...
journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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