Abstract:
:The role of the area postrema in radiation-induced emesis and taste aversion learning and the relationship between these behaviors were studied in cats. The potential involvement of neural factors which might be independent of the area postrema was minimized by using low levels of ionizing radiation (100 rads at a dose rate of 40 rads/min) to elicit a taste aversion, and by using body-only exposures (4500 and 6000 rads at 450 rads/min) to produce emesis. Lesions of the area postrema disrupted both taste aversion learning and emesis following irradiation. These results, which indicate that the area postrema is involved in the mediation of both radiation-induced emesis and taste aversion learning in cats under these experimental conditions, are interpreted as being consistent with the hypotheses that similar mechanisms mediate both responses to exposure to ionizing radiation, and that the taste aversion learning paradigm can therefore serve as a model system for studying radiation-induced emesis.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Rabin BM,Hunt WA,Chedester AL,Lee Jdoi
10.1016/0031-9384(86)90189-7subject
Has Abstractpub_date
1986-01-01 00:00:00pages
815-8issue
5eissn
0031-9384issn
1873-507Xpii
0031-9384(86)90189-7journal_volume
37pub_type
杂志文章abstract::Alzheimer's disease (AD) is one of the major neurological diseases of the elderly. How to safely and effectively remove the toxic Aβ42 peptide through blood-brain barrier (BBB) is considered to be an effective method for the prevention and treatment of AD. The compounds whose molecule weight is less than 400 Da and th...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2014.11.016
更新日期:2015-02-01 00:00:00
abstract::Women were divided into those eating at a decelerated or linear rate. Eating rate was then experimentally increased or decreased by asking the women to adapt their rate of eating to curves presented on a computer screen and the effect on food intake and satiety was studied. Decelerated eaters were unable to eat at an ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2008.10.011
更新日期:2009-02-16 00:00:00
abstract::Within 3-4 weeks after spinal transection, morphine-induced antinociception, assessed with the tail flick reflex in rats, is profoundly reduced. The cause of this decrement is unknown. The present studies were conducted to determine whether this phenomenon reflects a general loss in opiate activity or a selective decl...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00240-0
更新日期:1997-10-01 00:00:00
abstract::The present article analyzed the dramatic increase in alcohol ingestion that is known to occur in laboratory rats subjected to food restriction. In the first experiment, we wished to know when during the day food restricted animals consume the "extra" alcohol ration. Determinations of ethanol drinking at 3-h intervals...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(99)00078-5
更新日期:1999-09-01 00:00:00
abstract::Continuous perfusion of the granule cells in the ventral dentate gyrus with naloxone blocked the long-term potentiation (LTP) induced by high-frequency electrical stimulation of the posterolateral amygdala in freely-moving rats. This treatment also aggravated the stomach ulceration produced by cold restraint. LTP, on ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90121-h
更新日期:1992-04-01 00:00:00
abstract::Our previous studies showed that treating castrated, testosterone-treated male cynomolgus monkeys with Depo-Provera (medroxyprogesterone acetate, MPA) decreased ejaculatory performance and also measures of male sexual motivation by about 40%. Similarly, treating castrated, testosterone-treated males with the nonsteroi...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)90224-0
更新日期:1994-10-01 00:00:00
abstract::To study the physiological roles of endogenous opioid peptides in drinking and feeding behaviors, the effects of water deprivation and fasting on plasma immunoreactive (IR) beta-endorphin (beta-end), IR-Antidiuretic hormone (ADH) and IR-Prolactin (Prl), pituitary IR-beta-end and IR-methionine-enkephalin (IR-Met-enk) a...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(86)90293-3
更新日期:1986-01-01 00:00:00
abstract::Adapting behavior to dynamic stimulus-reward contingences is a core feature of reversal learning and a capacity thought to be critical to socio-emotional behavior. Impairment in reversal learning has been linked to multiple psychiatric outcomes, including depression, Parkinson's disorder, and substance abuse. A recent...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2016.03.034
更新日期:2016-07-01 00:00:00
abstract::Rats obtained less food than normal on a cyclic-ratio schedule during brief, 1-hr exposure to either moderate hypobaric hypoxia (BP = 435 Torr, PO2 approximately equal to 91 Torr) or to hypoxic hypoxia (BP = 750 Torr, PO2, approximately equal to 90 Torr), but not during hypobaric exposure with 36.5% oxygen (BP = 435 T...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90266-9
更新日期:1982-09-01 00:00:00
abstract::Micrencephalic offspring produced by gestational treatment with the antimitotic compound/methylazoxymethanol acetate (MAM) are remarkable for substantial preservation of function concurrent with severe neural stunting. Altered behaviors in these micrencephalics, including light shyness and response perseveration, are ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)00154-b
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Hydrogen sulfide (H2S) is the third gasotransmitter recently discovered after nitric oxide (NO) and carbon monoxide. Both NO and H2S are involved in multiple physiological functions. Whereas NO has been shown to vary with psychological stress, the influence of stress on H2S and the relationship between H2S a...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2017.05.023
更新日期:2017-10-01 00:00:00
abstract::Pain threshold was determined in female rats using the tail flick test. Latency to respond depended on the locus of the tail heated, with the most distal sites resulting in the shortest response times (Experiment 1). Tail flick latency also varied according to the time of day, with shorter response times recorded arou...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)90040-x
更新日期:1994-04-01 00:00:00
abstract::Sjogren's Syndrome (SS) patients have impaired salivary gland function and an elevated frequency of oral complaints. The taste complaints are thought to be due to sensory deficits that arise in the absence of sufficient saliva to maintain taste receptors. We assessed the subjective complaints, salivary production and ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)00211-m
更新日期:1995-01-01 00:00:00
abstract::Adult ovariectomized female rats received a testosterone propionate (TP) silastic implant (day 0) and were subsequently tested for mounting behavior. The number of females displaying mounting behavior increased from day 2 (0%) to day 14 (94%) following testosterone implantation. Olfactory bulbectomy (OB) performed on ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(91)90428-q
更新日期:1991-11-01 00:00:00
abstract::With the rising prevalence of obesity and related health problems increases, there is increased interest in the gastrointestinal system as a possible target for pharmacological or food-based approaches to weight management. Recent studies have shown that under normal physiological situations undigested nutrients can r...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2008.07.018
更新日期:2008-10-20 00:00:00
abstract::Roux-en-Y gastric bypass (RYGB) surgery might modify the gut microbiota composition differently in the three distinct anatomical sections of the small intestine compared to sham surgery. We showed that RYGB induced changes in the microbiota of the alimentary limb and the common channel resembling those seen after preb...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2013.06.008
更新日期:2013-07-02 00:00:00
abstract::Taste sensitivity and responsivity, two-tastant and taste-mixture discrimination performance, and taste preferences were examined prior to and after the selective desalivation of 48 male Long-Evans rats. Altered preference behavior was observed in rats after removal of the major salivary glands, as well as after remov...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90200-n
更新日期:1990-11-01 00:00:00
abstract::Mendelson and Gorzalka recently described a bilevel chamber for the evaluation of rodent sexual behavior. In initial studies it was observed that during 5 min adaptation periods prior to the introduction of a sexually receptive female rat, male rats with prior sexual experience in these chambers would move from level ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(89)90136-4
更新日期:1989-02-01 00:00:00
abstract::Intraperitoneal injections of the opiate antagonist naloxone decreased food intake in both vagotomized and sham-vagotomized rats. Consumption of liquid and solid sucrose, which were used in order to equate baseline intake, was equally suppressed in both groups under food-deprivation and appetitively-motivated conditio...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90345-6
更新日期:1982-11-01 00:00:00
abstract::17-β estradiol (E2) has been shown to modulate fear conditioning by influencing freezing behavior following re-exposure to either the conditioning context or a cue associated with shock. Fear-related behaviors other than freezing may be influenced differently by E2 replacement. Accordingly, the present study examined ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2014.04.030
更新日期:2014-05-28 00:00:00
abstract::Comparative studies of species differences and similarities in the regulation of courtship behavior afford an understanding of evolutionary pressures and constraints shaping reproductive processes and the relative contributions of hormonal, genetic, and ecological factors. Here, we review species differences and simil...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2004.08.021
更新日期:2004-11-15 00:00:00
abstract::The psychophysiological response due to stress of soldiers in actual combat operations have been determined by recent researchers, but there is a lack of knowledge about the most effective training methodologies to prepare these population for these new psychophysiological and tactical requirements. The aim of this st...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2019.01.009
更新日期:2019-03-15 00:00:00
abstract::Exposure of rats to an open-field results in a rapid rise in body temperature. Fifty-four percent of this rise in body temperature was blocked by intracerebroventricular administration of the antipyretic drug sodium salicylate. Intraperitoneal administration of indomethacin, a potent blocker of prostaglandin productio...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90263-0
更新日期:1987-01-01 00:00:00
abstract::Caloric restriction in mice can trigger gorging behaviour, which is characterized by periods of excessive food ingestion in a short time. Animals that gorge are thought to have a reduced metabolism compared to those that nibble their food over a longer period and might therefore be more able to compensate for reduced ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.07.005
更新日期:2007-12-05 00:00:00
abstract::There is accumulating data suggesting a neuroprotective activity of cholesterol, especially in stroke and Alzheimer's disease (AD). In the present study, a protective activity of this lipid in simulated neonatal anoxia was investigated. Rats were subjected to high cholesterol by feeding their dams with a diet enriched...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.06.009
更新日期:2004-09-30 00:00:00
abstract::Both subjective and objectively measured social status has been associated with multiple health outcomes, including weight status, but the mechanism for this relationship remains unclear. Experimental studies may help identify the causal mechanisms underlying low social standing as a pathway for obesity. Our objective...
journal_title:Physiology & behavior
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.physbeh.2016.04.024
更新日期:2016-08-01 00:00:00
abstract::The ergogenic effect of aspartate salts on performance during prolonged exercise is still controversial. Potential mechanisms of the suggested ergogenic effect of aspartate on exercise performance are a sparing of muscle glycogen stores or its faster resynthesis during exercise. The purpose of this study was to determ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(93)90036-f
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Evidence of metabolic adaptations following weight loss is available in the literature. However, the impact of different degrees of caloric restriction on a comprehensive panel including energy expenditure (EE) and intake (EI), appetite, palatability and olfactory performance remains to be investigated. Acco...
journal_title:Physiology & behavior
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.physbeh.2018.11.032
更新日期:2019-02-01 00:00:00
abstract::Post-exertional exacerbation of symptoms is one of the major characteristics of chronic fatigue syndrome (CFS). In this study, we evaluated the hypothesis that disturbances in circadian chronobiological regulation may play a role in generating this phenomenon. We recorded physical activity for 6-day periods in 16 wome...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(02)00808-9
更新日期:2002-09-01 00:00:00
abstract::Rats placed as intruders in a long-established colony showed significant elevations of plasma corticosterone after 10-20 minutes of intruding. This rise was prevented by 5 days pretreatment with chlordiazepoxide (5 mg/kg). The rats resident in the colony had significantly higher basal corticosterone concentrations com...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90152-5
更新日期:1984-09-01 00:00:00