Abstract：
:There is accumulating data suggesting a neuroprotective activity of cholesterol, especially in stroke and Alzheimer's disease (AD). In the present study, a protective activity of this lipid in simulated neonatal anoxia was investigated. Rats were subjected to high cholesterol by feeding their dams with a diet enriched with cholesterol. Half of these rats were subjected to anoxia. One and a half months later, the rats were tested for their ability to acquire a spatial memory, one group on the linear maze and the other on the Morris water maze. After these assessments, the level of total plasma cholesterol was measured. Rats from dams subjected to neonatal anoxia on standard diet performed worse than control rats in both types of behavioral experiments, whereas anoxic rats from dams were housed on hypercholesterolemic diet performed as control animals. It suggests that dietetic cholesterol applied by their dams protected rats against cognitive deficits elicited by neonatal anoxia. Furthermore, offspring of anoxic rats housed on standard diet had elevated levels of blood cholesterol in relation to control animals. Generally, anoxia affected the concentration of this lipid much stronger than hypercholesterolemic diet of their dams. It might mean that the anoxia-related rise of cholesterol could be involved in physiological phenomenon being an adaptive response to neurotoxic processes. This concept is discussed in relation to pathological mechanisms in AD.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Bohr Idoi
10.1016/j.physbeh.2004.06.009subject
Has Abstractpub_date
2004-09-30 00:00:00pages
703-11issue
4eissn
0031-9384issn
1873-507Xpii
S0031938404002744journal_volume
82pub_type
杂志文章abstract：:The pituitary-adrenal response of mother and infant squirrel monkeys was assessed under basal conditions and after 5, 10, or 20 min of separation followed by 30 min of reunion. All separation conditions produced equal increments of cortisol (approximately 50%) in both mothers and infants. These increments were lower t...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90029-0
更新日期：1985-06-01 00:00:00
abstract：:Disruption of attachment relations in early life is linked to greater vulnerability to depressive illness at later ages. Evidence suggests this process involves stress-induced activation of central inflammatory factors, though the specific mediators and processes involved are not known. We used a guinea pig model in w...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2018.11.040
更新日期：2019-02-01 00:00:00
abstract：:Recent studies suggest that the decreased drinking response to hypertonic saline produced by bilateral subdiaphragmatic vagotomy (VGX) is a function of the route of saline administration and the length of postoperative recovery. We determined the effects of VGX on drinking during the two hours after intraperitoneal an...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90086-5
更新日期：1982-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.07.019
更新日期：2008-01-28 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.07.001
更新日期：2006-10-30 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,meta分析
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更新日期：2012-06-06 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00146-a
更新日期：1995-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90298-3
更新日期：1988-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(03)00105-7
更新日期：2003-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90172-1
更新日期：1986-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90336-3
更新日期：1990-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.04.051
更新日期：2016-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.112760
更新日期：2020-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(99)00137-7
更新日期：1999-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90209-5
更新日期：1987-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.02.026
更新日期：2014-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00324-2
更新日期：1999-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2011.11.006
更新日期：2012-02-28 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90315-6
更新日期：1989-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.113194
更新日期：2021-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90357-8
更新日期：1992-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90009-x
更新日期：1984-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90482-h
更新日期：1992-12-01 00:00:00
abstract：:The influence of exogenous oxytocin (OT) on maternal and infant behavior over 60 min of suckling, which followed 6 h of isolation, was investigated on Day 12 of lactation in rats. Mothers administered 1 IU of OT or saline through an indwelling atrial catheter and their litters indicated a similar nursing and suckling ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00536-2
更新日期：1998-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00633-3
更新日期：2002-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90064-7
更新日期：1984-01-01 00:00:00
abstract：:Bulimia nervosa (BN) is a psychiatric illness characterized by eating binges followed by inappropriate behavioral attempts to compensate for the binges, usually vomiting or laxative abuse. Patients with BN have disturbances in the development of satiety during a meal as well as disturbances in functions of the upper g...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.11.010
更新日期：2006-02-28 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2013.03.005
更新日期：2013-04-10 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90099-x
更新日期：1994-03-01 00:00:00
abstract：:The purpose of the review is to highlight the influences of ambient temperature (T(a)) and caloric restriction (CR) on metabolism, cardiovascular function and behavior in mice. Standard vivarium ambient temperatures (T(a)?23 degrees C) are a mild cold stress for mice requiring elevated metabolic rate and food intake. ...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2004.04.025
更新日期：2004-07-01 00:00:00
