当前位置： SCI文献检索 > PHYSIOLOGY & BEHAVIOR期刊下所有文献 > Food and drug cues activate similar brain regions: a meta-analysis of functional MRI studies.

Food and drug cues activate similar brain regions: a meta-analysis of functional MRI studies.

Abstract：

:In healthy individuals, food cues can trigger hunger and feeding behavior. Likewise, smoking cues can trigger craving and relapse in smokers. Brain imaging studies report that structures involved in appetitive behaviors and reward, notably the insula, striatum, amygdala and orbital frontal cortex, tend to be activated by both visual food and smoking cues. Here, by carrying out a meta-analysis of human neuro-imaging studies, we investigate the neural network activated by: 1) food versus neutral cues (14 studies, 142 foci) 2) smoking versus neutral cues (15 studies, 176 foci) 3) smoking versus neutral cues when correlated with craving scores (7 studies, 108 foci). PubMed was used to identify cue-reactivity imaging studies that compared brain response to visual food or smoking cues to neutral cues. Fourteen articles were identified for the food meta-analysis and fifteen articles were identified for the smoking meta-analysis. Six articles were identified for the smoking cue correlated with craving analysis. Meta-analyses were carried out using activation likelihood estimation. Food cues were associated with increased blood oxygen level dependent (BOLD) response in the left amygdala, bilateral insula, bilateral orbital frontal cortex, and striatum. Smoking cues were associated with increased BOLD signal in the same areas, with the exception of the insula. However, the smoking meta-analysis of brain maps correlating cue-reactivity with subjective craving did identify the insula, suggesting that insula activation is only found when craving levels are high. The brain areas identified here are involved in learning, memory and motivation, and their cue-induced activity is an index of the incentive salience of the cues. Using meta-analytic techniques to combine a series of studies, we found that food and smoking cues activate comparable brain networks. There is significant overlap in brain regions responding to conditioned cues associated with natural and drug rewards.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Tang DW,Fellows LK,Small DM,Dagher A

doi

10.1016/j.physbeh.2012.03.009

subject

Has Abstract

pub_date

2012-06-06 00:00:00

pages

317-24

issue

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(12)00114-X

journal_volume

106

pub_type

杂志文章,meta分析

在线工具

Food and drug cues activate similar brain regions: a meta-analysis of functional MRI studies.