Plasma levels of dihydrotestosterone in the cycling rat: implications for the regulation of lordosis behavior.

Abstract:

:Exogenously administered dihydrotestosterone (DHT) is a potent inhibitor of sexual behavior in ovariectomized, estrogen-primed rats and endogenous DHT has been implicated as an inhibitor of sexual behavior in cycling rats. To determine the temporal relationship between DHT levels and the expression of sexual behavior, females were tested at midnight of each day of the 4-day estrous cycle for lordosis response to male mounts and subsequently bled. Plasma DHT levels were highest (177 +/- 10 pg/ml) at proestrus (P), when lordosis was fully expressed, fell to significantly lower levels (136 +/- 8, p less than 0.025) at estrus (E), and rose at diestrus I and diestrus II (DII) (152 +/- 8 and 154 +/- 10 respectively). Other female rats were bled from a jugular cannula at 4-hr intervals between midnight of DII and midnight of E. Plasma DHT was elevated from 1200 of P to 0400 of E and fell rapidly through 0800 of E. This elevation of endogenous DHT coincides with the expression of lordosis behavior, and the magnitude of this peak is many times lower than the concentrations reached by the minimal exogenous dose that inhibits lordosis behavior. This suggests that cyclic changes of DHT in the peripheral circulation do not inhibit lordosis behavior during the estrous cycle.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Dunlap KD,Sridaran R

doi

10.1016/0031-9384(88)90298-3

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

199-202

issue

2

eissn

0031-9384

issn

1873-507X

pii

0031-9384(88)90298-3

journal_volume

42

pub_type

杂志文章
  • Hypercholesterolemic diet applied to rat dams protects their offspring against cognitive deficits. Simulated neonatal anoxia model.

    abstract::There is accumulating data suggesting a neuroprotective activity of cholesterol, especially in stroke and Alzheimer's disease (AD). In the present study, a protective activity of this lipid in simulated neonatal anoxia was investigated. Rats were subjected to high cholesterol by feeding their dams with a diet enriched...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2004.06.009

    authors: Bohr I

    更新日期:2004-09-30 00:00:00

  • Prenatal stress alters maternal aggression in mice.

    abstract::Prenatal stress (heat and restraint) reduced pregnancy-induced and elevated postpartum aggression in Rockland-Swiss (R-S) albino female mice. Though prenatally-stressed females were indistinguishable from control animals with respect to parental behavior during the virgin state, the former displayed slightly lower lev...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(88)90252-1

    authors: Kinsley C,Svare B

    更新日期:1988-01-01 00:00:00

  • The effect of social environment on the immune response of female common voles in matriarchal laboratory groups.

    abstract::We used the hemagglutination test to investigate differences in the specific immune response to sheep red blood cells (SRBC) of female common voles living in matriarchal groups. The applied test proved to be a useful tool for studying the effect of the social environment on the immune response in small mammals. The re...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(00)00332-2

    authors: Heise SR,Van Acker A

    更新日期:2000-11-01 00:00:00

  • Dietary modulation of oral amphetamine intake in rats.

    abstract::The interaction of sucrose availability and oral self-administration of amphetamine was examined in 23 male Sprague-Dawley rats. Fourteen rats were given a 0.075 mg/ml amphetamine sulfate solution as their sole source of fluid and 9 rats were given water. Feeding conditions were alternated between weeks with both gran...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(88)90312-5

    authors: Kanarek RB,Marks-Kaufman R

    更新日期:1988-01-01 00:00:00

  • The corticomedial amygdala and learning in an agonistic situation in the rat.

    abstract::Social agonistic behaviour of intact male rats is strongly reduced by the experience of defeat by a dominant male conspecific. Small electrolytic lesions in the corticomedial amygdala strongly affected this behavioural change due to defeat. No effects of the lesions were observed before and during the defeat. Some lea...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(84)90311-1

    authors: Bolhuis JJ,Fitzgerald RE,Dijk DJ,Koolhaas JM

    更新日期:1984-04-01 00:00:00

  • Fat perception is related to PROP taster status.

    abstract::Individuals who are sensitive to the bitter compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) are also more sensitive to selected bitter and sweet substances, to sharp-tasting foods, and to the trigeminal irritant capsaicin. PTC/PROP tasters have a greater density of fungiform taste papillae and it i...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(96)00608-7

    authors: Tepper BJ,Nurse RJ

    更新日期:1997-06-01 00:00:00

  • Spatial processing and emotionality in aged NMRI mice: a multivariate analysis.

    abstract::The goal of this study was to investigate possible relationships between different aspects of behavioural decline in aged (17 months) NMRI mice by a multivariate analysis. These mice presented defects in spatial processing both in place learning in a Morris-type water maze and in spontaneous alternation in a Y-maze, a...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(93)90120-5

    authors: Lamberty Y,Gower AJ

    更新日期:1993-08-01 00:00:00

  • Otitis media and associations with overweight status in toddlers.

    abstract:INTRODUCTION:Otitis media (OM) is a significant disease that affects nearly all children early in life. Recently, childhood overweight has become an epidemic. Past research has demonstrated that a history of OM is related to food preferences and overweight through proposed physiological mechanisms. The purpose of this ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2011.01.002

    authors: Nelson HM,Daly KA,Davey CS,Himes JH,Synder DJ,Bartoshuk LM

    更新日期:2011-03-28 00:00:00

  • Effect of running wheel availability on circadian patterns of sleep and wakefulness in mice.

    abstract::Sleep/wake expression in mice varies predictably with circadian phase. Such circadian rhythms are known to depend on intact suprachiasmatic nuclei (SCN) in the hypothalamus, but the mechanism by which SCN activity modulates sleep/wake expression is unknown. This paper examines the possibility that circadian patterns o...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(88)90375-7

    authors: Welsh D,Richardson GS,Dement WC

    更新日期:1988-01-01 00:00:00

  • Chemical communication of handling stress in fish.

    abstract::We investigated whether juveniles of the nocturnal fish jundiá (Rhamdia quelen) and the diurnal fish Nile tilapia (Oreochromis niloticus) are able to chemically communicate stress to conspecifics. Groups of 8 fish were reared in tanks under recirculated water (water exchanged among all the tanks) for each species. Fis...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2011.03.009

    authors: Barcellos LJ,Volpato GL,Barreto RE,Coldebella I,Ferreira D

    更新日期:2011-06-01 00:00:00

  • Thermal control of mother-young contact in Norway rats: factors mediating the chronic elevation of maternal temperature.

    abstract::The chronically elevated heat production of lactating Norway rats makes them vulnerable to acute hyperthermia during pup contact and thereby limits the duration of such interactions. High lactational levels of progesterone and corticosterone may act in concert to increase maternal heat load. Specifically, progesterone...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90094-6

    authors: Adels LE,Leon M

    更新日期:1986-01-01 00:00:00

  • Chronic stress exposure may affect the brain's response to high calorie food cues and predispose to obesogenic eating habits.

    abstract::Exaggerated reactivity to food cues involving calorically-dense foods may significantly contribute to food consumption beyond caloric need. Chronic stress, which can induce palatable "comfort" food consumption, may trigger or reinforce neural pathways leading to stronger reactions to highly rewarding foods. We impleme...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2013.08.010

    authors: Tryon MS,Carter CS,Decant R,Laugero KD

    更新日期:2013-08-15 00:00:00

  • Numerical modeling of human mastication, a simplistic view to design foods adapted to mastication abilities.

    abstract::The human diet contains a large variety of aromas, tastes and textures. The latter is particularly important since it determines whether foods are difficult to process orally and thus can be one source of food avoidance. It has also been reported in recent literature that food texture was a main driver for satiation p...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:

    authors: Le Révérend B,Hartmann C

    更新日期:2014-01-30 00:00:00

  • Effects of paradoxical sleep deprivation in the rabbit.

    abstract::The effects of nonpharmacologically-induced deprivation of paradoxical sleep for a 24 hour period were studied in rabbits. Response characteristics commonly associated with the deprivation procedure in other species were observed, as well as features apparently peculiar to the rabbit. Like other mammals, rabbits: (1) ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90352-5

    authors: Pivik RT,Bylsma FW,Cooper P

    更新日期:1986-01-01 00:00:00

  • Influence of olfactory stimulation on nociceptive behavior in mice.

    abstract::The reactions elicited by nociceptive stimulations were studied in mice exposed to the presence of different odors: positive (attractive), negative (aversive), or neutral. In a first set of experiments, the animals were not habituated to the odors before the nociceptive stimuli were applied; in this case, the olfactor...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00024-3

    authors: Jahangeer AC,Mellier D,Caston J

    更新日期:1997-08-01 00:00:00

  • Changes in locomotor activity, core temperature, and heart rate in response to repeated cocaine administration.

    abstract::The effects of daily single injections of 20 mg/kg cocaine on locomotor activity, core temperature, and heart rate were determined by radiotelemetry. There was a progressive increase in locomotor activity over the 30-day treatment period. Cocaine-induced activity was 9-12-fold greater than that of saline-treated anima...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(96)00250-8

    authors: Ansah TA,Wade LH,Shockley DC

    更新日期:1996-11-01 00:00:00

  • A warmer indoor environment in the evening and shorter sleep onset latency in winter: The HEIJO-KYO study.

    abstract::Difficulty in initiating sleep is an important problem because it is associated with an increased incidence of depression, diabetes, myocardial infarction, and higher all-cause mortality. Although experimental studies in controlled settings have shown that warm skin temperature of the extremities (feet and hands) befo...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.05.022

    authors: Saeki K,Obayashi K,Tone N,Kurumatani N

    更新日期:2015-10-01 00:00:00

  • Effects of metabolism inhibitors, antiestrogens and antiandrogens on the androgen and estrogen induced sexual behavior in Japanese quail.

    abstract::The relative contribution of androgenic and estrogenic metabolites of testosterone to the activation of sexual behavior was studied in Japanese quail by using inhibitors of testosterone metabolism, antiestrogens and antiandrogens. These compounds were tested in castrated birds whose sexual behavior had been activated ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90429-4

    authors: Alexandre C,Balthazart J

    更新日期:1986-10-01 00:00:00

  • Changes in daily rhythms of body temperature and activity after a single social defeat in rats.

    abstract::The long-term consequences of social stress on daily rhythms of body temperature and activity in rats were studied by means of radiotelemetry with intraperitoneally implanted transmitters. Rats were subjected to a single social defeat by placing them into the territory of a male conspecific for 1 h. Social defeat caus...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)02182-5

    authors: Meerlo P,De Boer SF,Koolhaas JM,Daan S,Van den Hoofdakker RH

    更新日期:1996-04-01 00:00:00

  • Changes in the satiating effect of cholecystokinin over repeated trials.

    abstract::The study investigated the reasons for discrepant published results concerning a diminution of the satiating action of cholecystokinin (CCK) when it is administered over several trials. Throughout the experiment, rats were maintained on a schedule in which they were fasted for 5.5 h (except 5 ml of milk), and then giv...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2005.04.023

    authors: Duncan EA,Davita G,Woods SC

    更新日期:2005-07-21 00:00:00

  • The influence of exercise on energy balance changes induced by ventromedial hypothalamic lesion in the rat.

    abstract::The effects of a hypothalamic ventromedial area lesion on energy balance were tested in exercising rats and in sedentary rats to add further information about the type of obesity developed after ventromedial lesion. Four groups of six male Sprague-Dawley rats were used. Group 1: sham-lesioned and sedentary rats, which...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(93)90324-9

    authors: Monda M,Amaro S,De Luca B

    更新日期:1993-12-01 00:00:00

  • Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content.

    abstract:AIMS:Ghrelin is one of the most potent orexigens known to date. While the prevailing view is that ghrelin participates in the homeostatic control of feeding, the question arose as to whether consummatory responses evoked by this compound could be related to search for reward. We therefore attempted to delineate the inv...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2010.05.017

    authors: Disse E,Bussier AL,Veyrat-Durebex C,Deblon N,Pfluger PT,Tschöp MH,Laville M,Rohner-Jeanrenaud F

    更新日期:2010-09-01 00:00:00

  • Functional relationship between the hypothalamic vigilance area and PAG vigilance area.

    abstract::The vigilance reaction is characterized by a large bradycardia, a pressor response, and inspiratory apnea in anesthetized rabbits and the inhibition of movement in conscious rabbits. This affective response pattern can be elicited by electrical stimulation of the dorsolateral hypothalamus (the hypothalamic vigilance a...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00004-8

    authors: Duan YF,Winters R,McCabe PM,Green EJ,Huang Y,Schneiderman N

    更新日期:1997-09-01 00:00:00

  • Antipsychotic drug and body weight set-point.

    abstract:OBJECTIVE:Antipsychotic (AP) drugs frequently induce weight gain. The present study aimed at exploring a potential association between antipsychotic-induced weight gain and delayed negative alliesthesia for sweet stimuli. RESEARCH METHODS AND PROCEDURES:The study aimed at recruiting patients undergoing AP treatment, h...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.physbeh.2008.05.013

    authors: Khazaal Y,Chatton A,Claeys F,Ribordy F,Zullino D,Cabanac M

    更新日期:2008-09-03 00:00:00

  • Stressful and behavioral conditions that affect reversible cardiac arrest in the Nile tilapia, Oreochromis niloticus (Teleostei).

    abstract::The objective of the present investigation was to study the reversible cardiac arrest (RCA) to visual stimuli in the unrestrained Nile tilapia (Oreochromis niloticus) as well as the modulation of this response and its behavioral component (arousal/orientation or startle response) by external and internal factors that ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(01)00633-3

    authors: Ide LM,Hoffmann A

    更新日期:2002-02-01 00:00:00

  • The effects of small but abrupt change in temperature on the behavior of larval zebrafish.

    abstract::The zebrafish has become increasingly utilized in behavioral neuroscience, psychopharmacology, and behavior genetics research. However, little attention has been paid to the potential effects of environmental conditions fish are exposed to before and during behavioral testing. One such important factor is temperature,...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.113169

    authors: Abozaid A,Tsang B,Gerlai R

    更新日期:2020-12-01 00:00:00

  • Expression of arginine vasotocin and estrogen receptor alpha (ERα) in the shell gland altered by the specific phase relations of neural oscillations affects the reproductive physiology of Japanese quail.

    abstract::In order to study the effect of specific phase relation of neural oscillations on reproductive regulation and the response of AVT (the avian homologue of mammalian AVP) the expression of AVT in the shell gland was monitored in sexually immature quail. In this study 3-week-old female Japanese quail were administered wi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2016.07.001

    authors: Srivastava R,Chaturvedi CM

    更新日期:2016-10-15 00:00:00

  • Medial prefrontal cortex oxytocin-opioid receptors interaction in spatial memory processing in rats.

    abstract::Medial prefrontal cortex (mPFC), a forebrain structure, is involved in many brain functions such as learning and memory. In the present study, the effect of intra-mPFC microinjection of oxytocin, atosiban, morphine and naloxone was investigated on memory processing. Two guide cannulas were implanted into the right and...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.112599

    authors: Salighedar R,Erfanparast A,Tamaddonfard E,Soltanalinejad F

    更新日期:2019-10-01 00:00:00

  • Olfactory and gustatory functions and its relation to body weight.

    abstract::In the present study we investigated the influence of body weight as defined by BMI on gustatory and olfactory perception. A total of 66 healthy adults (41 females; 25 males) participated in psychophysical measurements using the "Sniffin' Sticks" test and "Taste Strips" test. Odor thresholds as well as discrimination ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.01.024

    authors: Skrandies W,Zschieschang R

    更新日期:2015-04-01 00:00:00

  • Rats exposed to traumatic stress bury unfamiliar objects--a novel measure of hyper-vigilance in PTSD models?

    abstract::Electric shocks lead to lasting behavioral deficits in rodents, and as such are often used to model post-traumatic stress disorder (PTSD) in the laboratory. Here we show that a single exposure of rats to 3 mA-strong shocks results in a marked social avoidance that lasts at least 28 days; moreover, the response intensi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2008.01.023

    authors: Mikics E,Baranyi J,Haller J

    更新日期:2008-06-09 00:00:00