Abstract：
:The relative contribution of androgenic and estrogenic metabolites of testosterone to the activation of sexual behavior was studied in Japanese quail by using inhibitors of testosterone metabolism, antiestrogens and antiandrogens. These compounds were tested in castrated birds whose sexual behavior had been activated by silastic implants of testosterone (T) or daily injections of testosterone propionate (TP) or diethylstilboestrol (DES). The aromatase inhibitor ATD only depressed T-induced behavior when injected at high doses and the 5 alpha-reductase inhibitor, 4MA was inactive in this respect. The antiestrogens, tamoxifen (TAM) and nitromifene citrate (CI-628) strongly depressed sexual behavior but they also drastically reduced the crowing behavior which is typically androgen-dependent which throws some doubts on the specificity of their action. The antiandrogens, flutamide and cyproterone acetate (CA), only had limited inhibitory effects on the copulatory behavior but similarly decreased only marginally the crowing. As they strongly depressed the cloacal gland growth, it can be ascertained that they were injected in sufficient amounts and their lack of action on crowing questions the ability of these compounds to inhibit brain processes even when they are androgen-dependent. Taken together with the results of previous experiments which tested the behavioral effects of the testosterone metabolites, the present data confirm the implication of both androgenic and estrogenic metabolites of testosterone in the activation of behavior. Their interaction remains, however, poorly defined and its understanding will probably require the identification of the biochemical processes which in the brain mediate the behavior.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Alexandre C,Balthazart Jdoi
10.1016/0031-9384(86)90429-4subject
Has Abstractpub_date
1986-10-01 00:00:00pages
581-91issue
4eissn
0031-9384issn
1873-507Xpii
0031-9384(86)90429-4journal_volume
38pub_type
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更新日期：1986-01-01 00:00:00
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更新日期：1990-05-01 00:00:00
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更新日期：1991-10-01 00:00:00
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更新日期：2005-01-31 00:00:00
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doi：10.1016/0031-9384(75)90108-0
更新日期：1975-09-01 00:00:00
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更新日期：2006-07-30 00:00:00
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更新日期：2018-09-01 00:00:00
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更新日期：1982-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-03-18 00:00:00
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更新日期：1997-06-01 00:00:00
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更新日期：1994-02-01 00:00:00
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更新日期：2014-03-14 00:00:00
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更新日期：2007-06-08 00:00:00
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更新日期：2019-11-01 00:00:00
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更新日期：2019-09-01 00:00:00
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更新日期：2006-07-30 00:00:00
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更新日期：2015-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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更新日期：2020-08-01 00:00:00
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更新日期：1990-08-01 00:00:00
