Abstract：
:Polychlorinated biphenyls are environmental contaminants known to affect neurobehavioral development in many laboratory studies using different animal models. Because of their bioaccumulation and long half-life they are a serious concern for our own species. The dioxin-like PCB congener 3,4,3',4'-tetrachlorobiphenyl (PCB 77) has estrogenic and anti-estrogenic properties, and has been shown to affect brain chemistry and behavior of developing rats when administered during gestation. Since many developmental outcomes in mammals depend upon the type of maternal care provided by the dams, we investigated the effects of two doses of PCB 77 (2 and 4 mg/kg administered during gestational days 6-18) on the maternal behavior of the treated dams. Both doses of PCB 77 reduced the amount of nursing time in which the dams displayed the high-crouch posture over postnatal days 1-6. In addition, the high dose increased the amount of maternal licking and grooming of the litters and the amount of time the dams spent on the nest. The high dose also increased pup mortality, and both doses reduced the weight gain of the litters during the first 6 days of life. These results document effects of PCB 77 on maternal behavior and serve to raise questions about the importance of maternal contributions to the developmental effects of this and similar contaminants.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Simmons SL,Cummings JA,Clemens LG,Nunez AAdoi
10.1016/j.physbeh.2004.10.022subject
Has Abstractpub_date
2005-01-31 00:00:00pages
81-6issue
1eissn
0031-9384issn
1873-507Xpii
S0031-9384(04)00477-9journal_volume
84pub_type
杂志文章abstract：:Studies have found that, under a wide variety of social circumstances, females are more likely than males to smile. The present article offers a theoretical explanation for this difference based on the premise that testosterone (along with other sex hormones) has evolved the tendency to alter brain functioning in ways...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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journal_title：Physiology & behavior
pub_type： 杂志文章
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abstract：:Foxy or Methoxy Foxy (5-methoxy-N,N-di(iso)propyltryptamine hydrochloride; 5-MeO-DIPT) is rapidly gaining popularity among recreational users as a hallucinogenic "designer drug." Unfortunately, much remain unknown about the consequences of its use on neuropsychological development or behavior. During one of two adoles...
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Physiology & behavior
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pub_type： 杂志文章,随机对照试验
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.05.010
更新日期：2014-06-22 00:00:00
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pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章
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pub_type： 杂志文章
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