Effects of fasting, intermittent feeding, or continuous parenteral nutrition on rat liver and brain energy metabolism as assessed by 31P-NMR.

Abstract:

:We wanted to determine what happens to brain PCr and ATP relative to that in liver during a series of dietary manipulation consisting of a severe fast, during eating (when nutrients are intermittently supplied), and during and after PN-100, when an excess amount of nutrients are continuously supplied, using 31P-NMR spectroscopy, in rats randomized to a Fast or Fed group in which energy was provided either as chow or as PN-100. Liver ATP concentration, and brain and liver 31P-nuclear magnetic resonance (NMR) spectras were measured serially. Brain energy metabolism was not different between groups and among days. In contrast, Fasted group showed increased liver ATP/Pi ratio and decreased ATP concentration and ATP/phosphomonoester ratio, there being no difference between Fed and PN-100 groups. Data suggest that brain energy metabolism is maintained regardless of whether energy is supplied intermittently or continuously, and during a negative caloric intake period, brain energy metabolism is quantitatively preserved, suggesting that ATP production by liver is subservient to brain ATP state.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Bodoky G,Yang ZJ,Meguid MM,Laviano A,Szeverenyi N

doi

10.1016/0031-9384(95)00078-w

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

521-7

issue

3

eissn

0031-9384

issn

1873-507X

pii

0031-9384(95)00078-W

journal_volume

58

pub_type

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