Concentration-detection functions for the odor of homologous n-acetate esters.

Abstract:

:Using air-dilution olfactometry, we measured concentration-response functions for the odor detection of the homologous esters ethyl, butyl, hexyl, and octyl acetate. Stimuli were delivered by means of an 8-station vapor delivery device (VDD-8) specifically designed to capture odor detection performance by humans under environmentally realistic conditions. Groups of 16-17 (half female) normosmic (i.e., having a normal olfaction) non-smokers (ages 18-38) were tested intensively. The method involved a three-alternative forced-choice procedure against carbon-filtered air, with an ascending concentration approach. Delivered concentrations were confirmed by gas chromatography before and during actual testing. A sigmoid (logistic) model provided an excellent fit to the odor detection functions both at the group and individual levels. Odor detection thresholds (ODTs) (defined as the half-way point between chance and perfect detection) decreased from ethyl (245 ppb by volume), to butyl (4.3 ppb), to hexyl acetate (2.9 ppb), and increased for octyl acetate (20 ppb). Interindividual threshold variability was near one and always below two orders of magnitude. The steepness of the functions increased slightly but significantly with carbon chain length. The outcome showed that the present thresholds lie at the very low end of those previously reported, but share with them a similar relative trend across n-acetates. On this basis, we suggest that a recent quantitative structure-activity relationship (QSAR) for ODTs can be applied to these and additional optimized data, and used to describe and predict not just ODTs but the complete underlying psychometric odor functions.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Cometto-Muñiz JE,Cain WS,Abraham MH,Gil-Lostes J

doi

10.1016/j.physbeh.2008.09.021

subject

Has Abstract

pub_date

2008-12-15 00:00:00

pages

658-67

issue

5

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(08)00305-3

journal_volume

95

pub_type

杂志文章
  • Adaptive timing of digestion and digestion-related thermogenesis in the pigeon.

    abstract::Pigeons were allowed to feed for 1 h either 2 h after lights on (morning pulse) or 3 h before lights off (evening pulse). Body temperature was measured radiotelemetrically. Faecal excretion, as an index of rate of digestion, was measured using load cells. At 22 degrees C, faecal excretion peaked just after lights-on i...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(03)00031-3

    authors: Laurila M,Hohtola E,Saarela S,Rashotte ME

    更新日期:2003-03-01 00:00:00

  • Hypothalamic gene expression during voluntary hypophagia in the Sprague-Dawley rat on withdrawal of the palatable liquid diet, Ensure.

    abstract::Sprague-Dawley rats over-consume calories over a 10 week period and develop diet-induced obesity (c. 100 g body weight differential vs controls) when fed a control pellet diet supplemented with chocolate Ensure liquid. Subsequent withdrawal of Ensure immediately reduces caloric intake by more than 50%, and results in ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2014.01.041

    authors: Mercer JG,Duncan JS,Archer ZA

    更新日期:2014-04-10 00:00:00

  • Circadian rhythms of body temperature and metabolic rate in naked mole-rats.

    abstract::Body temperature (T(b)) and metabolic rate (O(2) consumption) were measured continuously in naked mole-rats. Circadian rhythms were observed for both parameters. Body temperature increased at the end of the light phase in a 12L:12D cycle in three of four animals. The remaining animal exhibited a freerunning rhythm of ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(00)00280-8

    authors: Riccio AP,Goldman BD

    更新日期:2000-10-01 00:00:00

  • Naloxone influences retention behaviour depending on the degree of novelty inherent to the training situation.

    abstract::The effects of immediate posttraining subcutaneous administration of naloxone (0.25, 1 or 5 mg/kg) on retention behaviour of rats trained in an inhibitory avoidance task, subjected or not to familiarization with the training situation prior to the training trial (pretraining) have been investigated. Naloxone did not i...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(85)90394-4

    authors: Del Cerro S,Borrell J

    更新日期:1985-11-01 00:00:00

  • Prenatal stress impairs memory function in the early development of male-offspring associated with the gaba function.

    abstract::Prenatal stress (PS) induces cognitive deficits, abnormal behavior patterns and physical impairments in offspring, which disturbs the developmental process. GABA systems play a key role in the brain development. The developmental trajectories are less understood although PS increases the expression of GABAAR in young ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.113184

    authors: Shang Y,Chen R,Li F,Zhang H,Wang H,Zhang T

    更新日期:2021-01-01 00:00:00

  • Salicylate as a partial inhibitor of emotional fever and body weight set-point in rats: behavioral and neuroendocrine study.

    abstract::In this article, we report findings from behavioral and neuroendocrine experiments in rats under pharmacologically induced antipyretic conditions. Endpoints included emotional fever, body weight setpoint, and in situ corticotropin-releasing hormone mRNA (CRHmRNA) expression. Nine male Wistar rats were treated with ace...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(02)01002-8

    authors: Michel C,Frankham P,Cabanac M

    更新日期:2003-03-01 00:00:00

  • A new method for aversive Pavlovian conditioning of heart rate in rhesus monkeys.

    abstract::Aversive Pavlovian conditioning is an important tool used to investigate neurobiological mechanisms underlying the acquisition and expression of fear. Most studies have used nonprimate species employing electrical shock as the unconditioned stimulus (US). Although important advances have been made in understanding the...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(96)00145-x

    authors: Kalin NH,Shelton SE,Davidson RJ,Lynn DE

    更新日期:1996-10-01 00:00:00

  • Effect of insulin on endocrine pancreas function during late pregnancy in the rat.

    abstract::To partly or completely satisfy the increasing demand for insulin, pregnant rats were infused SC with human insulin (2.4 or 4.8 IU/day) from day 14 to day 20 of gestation. Cyclic control rats underwent the same procedure of 6 days of insulin-treatment. During the treatment all groups of rats were hypoglycaemic, but fo...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)00080-3

    authors: Wijkstra S,Moes H,Schuiling GA,Koiter TR

    更新日期:1995-09-01 00:00:00

  • Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression.

    abstract::Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of postsynaptic serotonin-1A (5-HT(1A)) receptors, both in receptor ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(01)00565-0

    authors: van der Vegt BJ,de Boer SF,Buwalda B,de Ruiter AJ,de Jong JG,Koolhaas JM

    更新日期:2001-09-01 00:00:00

  • A warmer indoor environment in the evening and shorter sleep onset latency in winter: The HEIJO-KYO study.

    abstract::Difficulty in initiating sleep is an important problem because it is associated with an increased incidence of depression, diabetes, myocardial infarction, and higher all-cause mortality. Although experimental studies in controlled settings have shown that warm skin temperature of the extremities (feet and hands) befo...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.05.022

    authors: Saeki K,Obayashi K,Tone N,Kurumatani N

    更新日期:2015-10-01 00:00:00

  • Bitter-responsive brainstem neurons: characteristics and functions.

    abstract::The sensation that humans describe as "bitter" is evoked by a large group of chemically diverse ligands. Bitter stimuli are avoided by a range of species and elicit reflex rejection, behaviors considered adaptations to the toxicity of many of these compounds. We review novel evidence for neurons that are narrowly tune...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2009.02.042

    authors: Travers SP,Geran LC

    更新日期:2009-07-14 00:00:00

  • Increased hypothalamic neuropeptide Y expression in deprived preweanling rats is reversed by intragastric infusion of milk.

    abstract::Lean, preweanling Zucker rat pups increase neuropeptide Y (NPY) expression in the hypothalamic arcuate nucleus in response to a 24-h deprivation of food, water, and maternal interaction as early as postnatal day 2 (P2). In this study, we examined if replacing nutritive or tactile aspects of maternal behavior to depriv...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(02)00644-3

    authors: Kowalski TJ,Ster AM,Smith GP

    更新日期:2002-03-01 00:00:00

  • Effects of oxytocin microinjected into the central amygdaloid nucleus and bed nucleus of stria terminalis on maternal aggressive behavior in rats.

    abstract::The central effect of oxytocin (OT) on the aggressive behavior of lactating rats was studied. Female rats are more aggressive than nonlactating resident females, vigorously attacking conspecific intruder male or females. This behavior is considered important for pup protection against infanticide. The present work aim...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2005.05.002

    authors: Consiglio AR,Borsoi A,Pereira GA,Lucion AB

    更新日期:2005-06-30 00:00:00

  • Conditioned control of ingestive behavior by acarbose-induced inhibition of sucrose ingestion in the rat.

    abstract::It has been reported that the addition of Acarbose, a alpha-glucosidase inhibitor, to a carbohydrate solution blocks a preference that otherwise would be displayed for that solution. One interpretation of those results is that the alteration in preference was caused by the diminished postabsorptive nutritive value of ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(94)90109-0

    authors: Davis JD,Perez MC,Kung TM

    更新日期:1994-03-01 00:00:00

  • The effects of mixing on behavior and circadian parameters of salivary cortisol in pigs.

    abstract::The present study describes an experiment that was carried out to study the effects of mixing pigs once at 25 kg, preceded by transportation for 1.5 h, on the behavior and the circadian rhythmicity of salivary cortisol. The frequency of agonistic interactions was higher for mixed pigs. This was not only the case immed...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00037-1

    authors: Ekkel ED,Savenije B,Schouten WG,Wiegant VM,Tielen MJ

    更新日期:1997-07-01 00:00:00

  • Zebrafish show long-term behavioral impairments resulting from developmental vitamin D deficiency.

    abstract::Vitamin D has been shown in a wide variety of species to play critical roles in neurodevelopment. Vitamin D deficiency disrupts development of the brain and can cause lasting behavioral dysfunction. Zebrafish have become an important model for the study of development in general and neurodevelopment in particular. Zeb...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.113016

    authors: Oliveri AN,Knuth M,Glazer L,Bailey J,Kullman SW,Levin ED

    更新日期:2020-10-01 00:00:00

  • Morus alba L. Diminishes visceral adiposity, insulin resistance, behavioral alterations via regulation of gene expression of leptin, resistin and adiponectin in rats fed a high-cholesterol diet.

    abstract::Ethanolic extract of leaves of Morus alba L. (M. alba), known as white mulberry, was orally administered (100 mg/kg b.wt) for 8 weeks to female Wistar rats that were fed a high-cholesterol diet (HCD), to investigate the potential of M. alba leaves in attenuation of obesity, dyslipidemia, insulin resistance, and defici...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2018.12.010

    authors: Metwally FM,Rashad H,Mahmoud AA

    更新日期:2019-03-15 00:00:00

  • Rare genetic forms of obesity: From gene to therapy.

    abstract::Monogenic non-syndromic obesity is characterized by severe early-onset obesity with abnormal eating behaviour and endocrine disorders. Genes contributing to these rare forms of obesity are mainly located in the leptin/melanocortin pathway, with typically an autosomal additive inheritance of obesity. The normal functio...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.113134

    authors: Clément K,Mosbah H,Poitou C

    更新日期:2020-12-01 00:00:00

  • Effects of cocaine-induced seizures during pregnancy in the rabbit.

    abstract::The effects of chronic administration of cocaine to pregnant rabbits on maternal seizures and on pregnancy outcome were studied. Cocaine (2, 3 or 4 mg/kg/injection) or saline was administered, I.V., twice daily, from gestation Day 8 (G8) to G29. There were no significant differences in maternal weight gain or pregnanc...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00170-4

    authors: Murphy EH,Chon J,Darvish-Sefat F,Diven K,Schumann M,Shumsky JS

    更新日期:1997-09-01 00:00:00

  • Subjective feelings of appetite of wholegrain breakfasts evaluated under controlled, laboratory and 'at home' conditions.

    abstract:BACKGROUND:Appetite regulating properties of foods are usually investigated under laboratory conditions, whereas in real life, foods are consumed under at home conditions. The objective of this study was to compare the acute effects of breakfasts when tested in a laboratory condition and in an at home condition. Appeti...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.physbeh.2018.06.024

    authors: Pasman WJ,Hendriks HFJ,Minekus MM,de Ligt RAF,Scholtes-Timmerman MJ,Clabbers NDS,Leonards NM,Johnson J,Bellmann S

    更新日期:2018-10-01 00:00:00

  • Increasing the number of inter-arch contacts improves mastication in adults with Down syndrome: a prospective controlled trial.

    abstract::Feeding difficulties due to their condition have been widely described for babies, children and adults with Down syndrome (DS). A previous study demonstrated that, compared with wearing a placebo appliance, wearing an occlusal appliance increased inter-arch dental contacts, improved the oral health status of adults wi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.03.034

    authors: Hennequin M,Mazille MN,Cousson PY,Nicolas E

    更新日期:2015-06-01 00:00:00

  • Effect of chronic restraint stress on carbohydrate metabolism in rat.

    abstract::There is some evidence suggesting that stress may induce diabetes mellitus; the effects of restraint stress however need to be investigated. The present study investigates the role of chronic restraint stress on carbohydrate metabolism in male rats. The animals of the stressed group (n=8) were exposed to different res...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2006.06.023

    authors: Zardooz H,Zahedi Asl S,Gharib Naseri MK,Hedayati M

    更新日期:2006-10-30 00:00:00

  • Altered responsiveness to ambiental stimuli in altered thyroidal states.

    abstract::Hypothyroidal rats produced by low iodine diet or propylthiouracyl (PTU) were less active in the open field and received fewer food reinforcements than controls in a lever press situation at both 22 degrees C and 1 degree C. The hypothyroid rats also pressed less when heat was the reinforcer. On the other hand, hypert...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(87)90140-5

    authors: Rial RV,Tur JA,Palmer AM,Tur J

    更新日期:1987-01-01 00:00:00

  • A high-protein diet enhances satiety without conditioned taste aversion in the rat.

    abstract::In order to determine the respective roles of conditioned food aversion, satiety and palatability, we studied behavioral responses to a 50% total milk protein diet, compared with those to a normal protein diet containing 14% total milk protein. Different paradigms were employed, including meal pattern analysis, two-ch...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(02)00977-0

    authors: Bensaïd A,Tomé D,L'Heureux-Bourdon D,Even P,Gietzen D,Morens C,Gaudichon C,Larue-Achagiotis C,Fromentin G

    更新日期:2003-02-01 00:00:00

  • Gastric compliance in bulimia nervosa.

    abstract::Bulimia nervosa (BN) is a psychiatric illness characterized by eating binges followed by inappropriate behavioral attempts to compensate for the binges, usually vomiting or laxative abuse. Patients with BN have disturbances in the development of satiety during a meal as well as disturbances in functions of the upper g...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2005.11.010

    authors: Zimmerli EJ,Walsh BT,Guss JL,Devlin MJ,Kissileff HR

    更新日期:2006-02-28 00:00:00

  • Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes.

    abstract::5-HT(1B) receptors have a regulatory role in serotonergic activity and influence feeding behavior and body weight. Because the absence of 5-HT(1B) receptors may cause changes in this regulation, body weight was measured in male and female 5-HT(1B) receptor knockout (5-HT(1B) KO) and wildtype (WT) mice from weaning unt...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(01)00589-3

    authors: Bouwknecht JA,van der Gugten J,Hijzen TH,Maes RA,Hen R,Olivier B

    更新日期:2001-11-01 00:00:00

  • Behavioral models of binge-type eating.

    abstract:PURPOSE:To describe and evaluate behavioral models of binge-type eating. DATA IDENTIFICATION:Studies were identified using Medline and hand searches of bibliographies of identified articles. STUDY SELECTION:Isomorphic studies were selected that were judged to have some measure of construct validity. DATA EXTRACTION:...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.physbeh.2004.04.036

    authors: Corwin RL,Buda-Levin A

    更新日期:2004-08-01 00:00:00

  • Postpartum aggression and plasma prolactin levels in mice exposed to lead.

    abstract::Young-adult, female Binghamton Heterogeneous Stock (HET) mice either were exposed to lead via drinking water from birth, or not. Eight days after giving birth to their first litter of pups (at about 70-75 days of age), postpartum aggression tests were conducted. Unfamiliar Het male intruders were introduced to the pri...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(89)90053-x

    authors: Burright RG,Engellenner WJ,Donovick PJ

    更新日期:1989-11-01 00:00:00

  • Assessment of mouse anxiety-like behavior in the light-dark box and open-field arena: role of equipment and procedure.

    abstract::Light-dark box and open field are conventional tests for assessment of anxiety-like behavior in the laboratory mice, based on approach-avoidance conflict. However, except the basic principles, variations in the equipment and procedures are very common. Therefore, contribution of certain methodological issues in differ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2014.05.006

    authors: Kulesskaya N,Voikar V

    更新日期:2014-06-22 00:00:00

  • Seasonality in squirrel monkeys (Saimiri sciureus): social facilitation by females.

    abstract::The extent to which social living arrangements influenced seasonal changes in physiology and behavior was examined in adult squirrel monkeys (Saimiri sciureus). Data were collected over 20 months (encompassing two breeding seasons) from animals that were housed in three mixed-sex social configurations that varied in t...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(96)00134-5

    authors: Schiml PA,Mendoza SP,Saltzman W,Lyons DM,Mason WA

    更新日期:1996-10-01 00:00:00