Naloxone influences retention behaviour depending on the degree of novelty inherent to the training situation.

Abstract:

:The effects of immediate posttraining subcutaneous administration of naloxone (0.25, 1 or 5 mg/kg) on retention behaviour of rats trained in an inhibitory avoidance task, subjected or not to familiarization with the training situation prior to the training trial (pretraining) have been investigated. Naloxone did not influence performance of pretrained rats not subjected to footshock at training. The drug did not significantly modify retention latencies of pretrained rats subjected to a weak footshock. However, administration of naloxone facilitated retention behaviour of non-pretrained rats subjected to a weak footshock. Likewise, naloxone significantly increases retention latencies of pretrained rats subjected to a high footshock at the training trial. These data indicate that naloxone influences retention behaviour depending on the degree of novelty linked to the training situation: a facilitatory effect of the drug is observed when the training trial becomes associated with a clear novel situation for the animals (high footshock in pretrained rats or a weak footshock in non-pretrained animals).

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Del Cerro S,Borrell J

doi

10.1016/0031-9384(85)90394-4

subject

Has Abstract

pub_date

1985-11-01 00:00:00

pages

667-71

issue

5

eissn

0031-9384

issn

1873-507X

pii

0031-9384(85)90394-4

journal_volume

35

pub_type

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