Abstract:
:The effects of immediate posttraining subcutaneous administration of naloxone (0.25, 1 or 5 mg/kg) on retention behaviour of rats trained in an inhibitory avoidance task, subjected or not to familiarization with the training situation prior to the training trial (pretraining) have been investigated. Naloxone did not influence performance of pretrained rats not subjected to footshock at training. The drug did not significantly modify retention latencies of pretrained rats subjected to a weak footshock. However, administration of naloxone facilitated retention behaviour of non-pretrained rats subjected to a weak footshock. Likewise, naloxone significantly increases retention latencies of pretrained rats subjected to a high footshock at the training trial. These data indicate that naloxone influences retention behaviour depending on the degree of novelty linked to the training situation: a facilitatory effect of the drug is observed when the training trial becomes associated with a clear novel situation for the animals (high footshock in pretrained rats or a weak footshock in non-pretrained animals).
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Del Cerro S,Borrell Jdoi
10.1016/0031-9384(85)90394-4subject
Has Abstractpub_date
1985-11-01 00:00:00pages
667-71issue
5eissn
0031-9384issn
1873-507Xpii
0031-9384(85)90394-4journal_volume
35pub_type
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