Abstract:
:The research literature suggests that oxidative stress and pro-inflammatory factors influence neurotrophins in vitro. However, there is insufficient information about their effects on exercise training conditions, especially during high intensity trainings. This study aimed to compare the effects of 6weeks of high intensity interval and continuous training regimens on brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), hydrogen peroxide (H2O2), and tumor necrosis factor alpha (TNF-α) in the rat brain. For this purpose, twenty-four Albino Wistar rats were divided into sedentary control (SC), high intensity interval training (HIIT), and continuous training (CT) groups. Both HIIT and CT regimens increased H2O2 level and TNF-α concentration in the brain, and the alterations made were greater following HIIT than CT. In addition, both HIIT and CT regimens increased BDNF and GDNF concentrations significantly, with a higher elevation following HIIT than CT. Furthermore, H2O2 level and TNF-α concentration correlated positively with both BDNF and GDNF concentrations. Generally, high intensity interval training regimen, rather than continuous training regimen, is highly potential to improve BDNF and GDNF through a greater increase in H2O2 and TNF-α as oxidative stress and pro-inflammatory factors.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Afzalpour ME,Chadorneshin HT,Foadoddini M,Eivari HAdoi
10.1016/j.physbeh.2015.04.012subject
Has Abstractpub_date
2015-08-01 00:00:00pages
78-83eissn
0031-9384issn
1873-507Xpii
S0031-9384(15)00207-3journal_volume
147pub_type
杂志文章abstract::The present experiments were based on the rat resident-intruder paradigm and aimed at better understanding the long-term conditioning properties of this social stress model. Intruders were exposed to aggressive conspecifics residents. During 3 daily encounters, intruders were either defeated or threatened by residents...
journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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pub_type: 杂志文章,评审
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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更新日期:2000-03-01 00:00:00
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journal_title:Physiology & behavior
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更新日期:2015-01-01 00:00:00
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