Abstract:
:In this article, we report findings from behavioral and neuroendocrine experiments in rats under pharmacologically induced antipyretic conditions. Endpoints included emotional fever, body weight setpoint, and in situ corticotropin-releasing hormone mRNA (CRHmRNA) expression. Nine male Wistar rats were treated with acetylsalicylic acid (ASA) 0.04 g/kg ip in vehicle. On alternating days, all rats received saline (0.9% w/v) as a control. ASA was selected chiefly for its antipyretic and also for effects on metabolism. It has been demonstrated that gentle handling affects body weight and body temperature in rats. In Experiment 1, we investigated whether blocking emotional fever by ASA treatment would inhibit the lowering of the body weight setpoint induced by handling of the rats. Rats were exposed to a daily food-hoarding session under handling stress, and their body weight setpoints were calculated from the hoarding measurements. As rats received ASA and saline in an alternating manner, two setpoints were calculated. In Experiment 2, we performed neuroendocrine analyses of CRHmRNA expression in the same group of animals from Experiment 1. CRHmRNA was determined by in situ hybridization. Results indicated that ASA treatment in rats significantly decreased the body weight setpoint (P=.02) and significantly prevented increases in body temperature due to emotional fever (P=.03) when compared to their control values. Findings also revealed that hypothalamic CRH expression was increased when rats were treated with ASA. ASA did partially block fever induced by handling, but it is difficult to confirm whether emotion was also inhibited by treatment. Taken together, these results indicate that salicylates affect energy balance and might be a good inhibitor of body weight gain in rats.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Michel C,Frankham P,Cabanac Mdoi
10.1016/s0031-9384(02)01002-8subject
Has Abstractpub_date
2003-03-01 00:00:00pages
357-63issue
3eissn
0031-9384issn
1873-507Xpii
S0031938402010028journal_volume
78pub_type
杂志文章abstract::Cardiomyopathic hamsters (CMH) develop heart disease early in life which leads to congestive heart failure and death as these hamsters age. We have previously shown that living in constant light or other non-24-h light-dark (LD) cycles can increase longevity in these hamsters, and the current experiment examined poten...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00250-3
更新日期:1997-11-01 00:00:00
abstract::We describe and test a programmable feeding system based on a contact eatometer, previously developed in our laboratory, consisting of a swinging grid beneath a hopper that is moved by the rat each time it wants to eat. This has not been connected to a solenoid that can block the movement of the grid to prevent access...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)02225-2
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Evidence of metabolic adaptations following weight loss is available in the literature. However, the impact of different degrees of caloric restriction on a comprehensive panel including energy expenditure (EE) and intake (EI), appetite, palatability and olfactory performance remains to be investigated. Acco...
journal_title:Physiology & behavior
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.physbeh.2018.11.032
更新日期:2019-02-01 00:00:00
abstract::Freshly cooked chicken broth was prepared with several concentrations (0.06-0.32 M) of added NaCl. In the first study, subjects were presented with pairs of samples, each having the same concentration of NaCl (salt) but one of which contained 0.01 M monosodium glutamate (MSG). The subjects preferred the sample with ad...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章
doi:10.1016/s0031-9384(98)00160-7
更新日期:1998-08-01 00:00:00
abstract::Others have shown that frontally dominant EEG activity of around 7-8 Hz is linked to ongoing cognitive performance. Interestingly, we have found that this EEG activity is particularly evident during the relatively artefact-free period following "lights out" at bedtime when people report "thinking" when lying relaxed i...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章
doi:10.1016/j.physbeh.2004.03.006
更新日期:2004-06-01 00:00:00
abstract::The relationship between performance in an avoidance conditioning paradigm and the plasma glucose levels of Sprague-Dawley rats was examined in two experiments. In Experiment 1 we investigated whether glucose levels varied with the animal's relative success at acquiring the avoidance task. Results indicated that anima...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90108-e
更新日期:1992-04-01 00:00:00
abstract::The green anole, Anolis carolinensis, is the most thoroughly studied North American lizard species, yet little is known about the circadian system of this species. Studies in several lizard species, including Anolis, support the hypothesis that the pineal organ is the site of a major circadian pacemaker that controls ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(00)00340-1
更新日期:2000-10-01 00:00:00
abstract::The influences of three methyl xanthines (MX) on human taste responsivity, caffeine, theophylline, and theobromine, were examined using blind control procedures. Taste responsivity in the same subjects was determined using the matching procedure described by Schiffman (Study 1) and the whole-mouth procedure described ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90347-5
更新日期:1992-09-01 00:00:00
abstract::Chemoreception of foodstuff in the gut is performed by endocrine cells dispersed in the gut epithelium. They are bipolar cells extending an apical process to the gut lumen and releasing their messenger substances from the cell base in response to the apical stimuli. The cells share cell-biological features with neuron...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/0031-9384(91)90198-w
更新日期:1991-05-01 00:00:00
abstract::To characterize learning/memory profiles for the first time in the genetically heterogeneous NIH-HS rat stock, and to examine whether these are associated with anxiety, we evaluated NIH-HS rats for spatial learning/memory in the Morris water maze (MWM) and in the following anxiety/fear tests: the elevated zero-maze (Z...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.03.003
更新日期:2015-05-15 00:00:00
abstract::The neurotoxin capsaicin has been shown to selectively interfere with unmyelinated sensory fibers, as well as leading to depletions of substance P and other peptides. Meal pattern analysis was performed both before and after treatment with capsaicin in twelve adult male Sprague-Dawley rats. Capsaicin treatment only br...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90056-4
更新日期:1987-01-01 00:00:00
abstract::The European rabbit, both in its wild and domesticated forms, has been a pioneer species in the study of mammalian chemical communication, and illustrates well the difficulty of understanding the functional significance of these often complex signals. Here we investigate the performance of one of the rabbit's most con...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2008.03.005
更新日期:2008-06-09 00:00:00
abstract::Oral cavity edge perception acuity relative to the fingertip has previously been evaluated by the utilization of cognitively-loaded, stereognostic methods. However, with the lack of connection of the tongue to the visual association cortex, there is concern the superior acuity of the fingertip may be attributable to t...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113035
更新日期:2020-10-01 00:00:00
abstract::Prior work indicates that rats prefer a mixture of sucrose and maltodextrin to either carbohydrate alone. The present experiment examined whether a sucrose + maltodextrin (S + M) mixture also increases total fluid intake as does saccharin + carbohydrate mixtures. In 23 h/day, one-bottle tests male rats consumed more o...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00478-2
更新日期:1998-02-15 00:00:00
abstract::In nature the degu has been observed to deposit and to investigate scents. This study employed a captive group of these animals to investigate their responses to conspecific urinary marks in a neutral arena. Both sex classes served as subjects. They were presented with urine obtained from males, from females and a sal...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(85)90027-7
更新日期:1985-06-01 00:00:00
abstract::Intake of an initial substance (e.g., 0.15% saccharin) is suppressed when the presentation of this substance precedes the availability of a preferred solution (e.g., 32% sucrose) in brief daily pairings. The present experiments show that degree of this anticipatory contrast effect is related to the relative hedonic va...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)90386-7
更新日期:1994-06-01 00:00:00
abstract::Food preference and fish-attractive parameters were studied on 1000 15- to 18-month-old Nile crocodiles, using two-choice preference tests. All three experimental groups preferred live fish over dead fish and live chicks, while ground meat was the last choice. As for fish attractiveness, motion, freshness, size, color...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(91)90489-b
更新日期:1991-07-01 00:00:00
abstract::To investigate the role of gastric contractility in the prepyloric control of meal size, we administered atropine methyl nitrate (3 mg/kg,ip) or saline prior to 30-min tests on 3 separate days in which 0.8 M sucrose was ingested by rats after 1 h of food deprivation. Ingested 0.8 M sucrose accumulated in the stomach a...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)02132-9
更新日期:1996-02-01 00:00:00
abstract::Gold thioglucose (GTG) has been known to be an obesity causing agent for over 40 years. GTG works by affecting dendrites in the mouse ventromedial hypothalamus (VMH) producing a permanent VMH lesion and subsequent hyperphagia and obesity. We have investigated the effect of beta-thioglucose (BTG), a glucose antimetabol...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(89)90005-x
更新日期:1989-09-01 00:00:00
abstract::Current study attempted to determine whether repeated smooth pursuit trials using theta motion, in which the directions of retinal image-motion and object-motion are opposed, yield pursuit adaptation. Adaptation trials consisted of 350 step-ramp trials using theta motion, and pre- and post-trials using first-order mot...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113245
更新日期:2021-02-01 00:00:00
abstract::This paper was written to pay honor to Professor Gerard P. Smith because of his strong influence on me to study the ingestion of sweet and fat mixtures. Three experiments are reported here, in which the laboratory rat was given an emulsion of a glucose+saccharin mixture with corn oil. In the first experiment, a two-bo...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.04.049
更新日期:2004-08-01 00:00:00
abstract::Food marketing is a major contributor to high rates of obesity and diet-related disease among children. Researchers, advocates, and policymakers have called for improvements in the nutrition quality of foods marketed to children to improve children's health. In the United States, for over 10 years, the food and bevera...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2020.113139
更新日期:2020-12-01 00:00:00
abstract::We have investigated the effects of peripherally administered pyruvate and lactate on the intake of high fat (HF) and low fat (LF) diets by a strain of rat either sensitive (Osborne-Mendel, OM) or resistant (SSB/Pl) to high fat-induced obesity. Both pyruvate and lactate inhibited the intake of HF and LF diets by OM ra...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)02109-4
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Time-restricted feeding (TRF), a key component of intermittent fasting regimens, has gained considerable attention in recent years due to reversing obesity and insulin resistance. To the best of our knowledge, here, we reported for the first time the underlying mechanistic therapeutic efficacy of TRF against...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2021.113313
更新日期:2021-03-15 00:00:00
abstract::This article describes pleasant IAPS pictures that elicit low-arousal rather than the high-arousal physiological responses previously reported in the literature. Thirty-two International Affective Picture System (IAPS) photographs were grouped into 4 sets of 8 photographs: highly pleasant-arousing (sexual content and ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.03.031
更新日期:2007-08-15 00:00:00
abstract::The hypothalamus is critically involved in energy homeostasis and is an appropriate focus for research investigating the central neural underpinnings of obesity, anorexia and normal food intake. However, little is known regarding pathways and mechanisms that convey relevant hypothalamic signals to the brainstem circui...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(03)00105-7
更新日期:2003-06-01 00:00:00
abstract::Electrophysiological and behavioral experiments were performed to determine whether the taste system of the aquatic salamander, axolotl, discriminates taste stimuli. Taste responses were recorded extracellularly from the glossopharyngeal nerve bundle. The behavioral responses of axolotls towards various concentrations...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)90269-0
更新日期:1994-07-01 00:00:00
abstract::Amino acid deficiency was modeled by feeding rats a diet deficient in the essential L-amino acid, L-lysine (L-lys). There is a rapid anorectic response to such a diet, and a strong preference for L-lys develops during the deficiency. While the brain appears to trigger this preference, the peripheral pathways that info...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(01)00426-7
更新日期:2001-04-01 00:00:00
abstract::Studies from the last two decades have pointed to multiple mechanisms of fear. For responding to predators, there is a group of highly interconnected hypothalamic nuclei formed by the anterior hypothalamic nucleus, the ventromedial hypothalamic nucleus and the dorsal premammillary nucleus—the predator-responsive hypot...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.10.013
更新日期:2015-12-01 00:00:00
abstract::The effect of oil enriched diets on sexual and exploratory behavior has been studied in male rats undernourished in utero and during lactation. At 20 days of age, for a period of 4 months, these animals were fed with 3 different diets: standard diet, standard diet enriched with 7% soybean oil, and standard diet enrich...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00150-9
更新日期:1997-07-01 00:00:00