Abstract:
:Light-dark box and open field are conventional tests for assessment of anxiety-like behavior in the laboratory mice, based on approach-avoidance conflict. However, except the basic principles, variations in the equipment and procedures are very common. Therefore, contribution of certain methodological issues in different settings was investigated. Three inbred strains (C57BL/6, 129/Sv, DBA/2) and one outbred stock (ICR) of mice were used in the experiments. An effect of initial placement of mice either in the light or dark compartment was studied in the light-dark test. Moreover, two tracking systems were applied - position of the animals was detected either by infrared sensors in square box (1/2 dark) or by videotracking in rectangular box (1/3 dark). Both approaches revealed robust and consistent strain differences in the exploratory behavior. In general, C57BL/6 and ICR mice showed reduced anxiety-like behavior as compared to 129/Sv and DBA/2 strains. However, the latter two strains differed markedly in their behavior. DBA/2 mice displayed high avoidance of the light compartment accompanied by thigmotaxis, whereas the hypoactive 129 mice spent a significant proportion of time in risk-assessment behavior at the opening between two compartments. Starting from the light side increased the time spent in the light compartment and reduced the latency to the first transition. In the open field arena, black floor promoted exploratory behavior - increased time and distance in the center and increased rearing compared to white floor. In conclusion, modifications of the apparatus and procedure had significant effects on approach-avoidance behavior in general whereas the strain rankings remained unaffected.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Kulesskaya N,Voikar Vdoi
10.1016/j.physbeh.2014.05.006subject
Has Abstractpub_date
2014-06-22 00:00:00pages
30-8eissn
0031-9384issn
1873-507Xpii
S0031-9384(14)00261-3journal_volume
133pub_type
杂志文章abstract::Do restrained and unrestrained eaters differ in their brain response to food odor? We addressed this question by examining restrained eaters' brain response to food (chocolate) and non-food (geraniol, floral) odors, both when odor was attended to and when ignored. Using olfactory event-related potentials (OERPs), we f...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章
doi:10.1016/j.physbeh.2005.10.008
更新日期:2006-02-28 00:00:00
abstract::Syrian golden hamsters (Mesocricetus auratus) received bilateral lesions aimed at the ventromedial hypothalamus (VMH) or a sham lesion. In the first study, some of the animals in each surgical group were housed in standard sedentary conditions while others had free access to running wheels. The lesions produced a 30% ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(86)90324-0
更新日期:1986-01-01 00:00:00
abstract::In the following experiments, an attempt was made to determine the role of the ovary in the control of food intake and body weight regulation during lactation. In the first study, it was found that concentrations of estradiol benzoate effective in suppressing food intake and body weight in nonlactating animals were no...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(76)90016-0
更新日期:1976-12-01 00:00:00
abstract::Highly purified insulin-like growth factors I and II and insulin (100 ng peptide/animal) were injected intracerebroventricularly in rats and the effect on 24 hour food consumption examined. IGF-II injections resulted in a 21% decrease in food intake and 4% body weight loss over the 24 hour period following peptide adm...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90279-4
更新日期:1987-01-01 00:00:00
abstract::Our previous work demonstrated that androgens in the medial amygdala (MeA) of castrated male rats maintained noncontact erections (NCEs), which occur during exposure to an inaccessible receptive female, for one week after implantation. The present experiments investigated the effects of implantation into the MeA of ei...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2011.02.003
更新日期:2011-06-01 00:00:00
abstract::There is evidence of a sexually dimorphic effect of serotonin administration during the critical period of sexual differentiation on gonadal hormone secretion in adulthood. To investigate the possible involvement of catecholamines on these mechanisms, we have injected dopamine or noradrenaline intraventricularly into ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90175-2
更新日期:1992-03-01 00:00:00
abstract::Acutely infected animals show a set of non-specific behavioral changes known as sickness behavior. Recent studies have shown that occurrence of sickness behavior is regulated according to a motivational perspective. Thus, the display of sickness behavior may compete with display of other behaviors. In this work, we so...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.02.011
更新日期:2006-05-30 00:00:00
abstract::The oxytocin (OT) neural system is thought to be involved in the underlying mechanisms that guide the development of social behaviors. In the present study, we examined the effects of neonatal oxytocin manipulation in mice. Within 24 hours after birth, pups in the treatment group randomly received an intraperitoneal i...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2014.05.010
更新日期:2014-06-22 00:00:00
abstract::Disruption of attachment relations in early life is linked to greater vulnerability to depressive illness at later ages. Evidence suggests this process involves stress-induced activation of central inflammatory factors, though the specific mediators and processes involved are not known. We used a guinea pig model in w...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2018.11.040
更新日期:2019-02-01 00:00:00
abstract::Sham-operated male doves displayed greater nesting activity under long days (16L:8D) than under short days (8L:16D). This difference was abolished by pinealectomy--the activity of long-day pinealectomized birds dropped to a level comparable to that seen on short days. Removal of the pineal had no effect under the shor...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90330-4
更新日期:1982-11-01 00:00:00
abstract::alpha-Adrenergic receptors within the paraventricular hypothalamus (PVN) modulate feeding such that activation of alpha 2-adrenoceptors by drugs such as clonidine (CLON) increase feeding; whereas activation of alpha 1-adrenoceptors by drugs such as phenylpropanolamine (PPA) suppress feeding. Prior studies suggest that...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90345-3
更新日期:1992-09-01 00:00:00
abstract::Behavioral and physiological effects of alarm pheromones emanating from stressed conspecific animals were investigated. Experimentally naive male Wistar rats were exposed to the test chambers containing alarm pheromones, which had been released by other rats receiving foot shocks in the same chamber beforehand. Along ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(00)00370-x
更新日期:2001-01-01 00:00:00
abstract::Rats shifted from a 32% to 4% sucrose solution consume substantially less 4% sucrose than unshifted animals that experience only the 4% solution. This negative contrast effect was found to be attenuated by lesions of the lateral aspects of the amygdala (basolateral, lateral, and basomedial nuclei) and eliminated by le...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90035-0
更新日期:1984-11-01 00:00:00
abstract::Vagal afferents are a vital link between the peripheral tissue and central nervous system (CNS). There is an abundance of vagal afferents present within the proximal gastrointestinal tract which are responsible for monitoring and controlling gastrointestinal function. Whilst essential for maintaining homeostasis there...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2014.03.012
更新日期:2014-09-01 00:00:00
abstract::It is well known that several amino acids, such as arginine, are potent stimuli for insulin and glucagon secretion from the pancreas. Recently, vagal arginine sensors, which modulate arginine-induced pancreatic hormone secretion, have been reported to exist in the liver. The present investigation was designed to evalu...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)00390-4
更新日期:1995-04-01 00:00:00
abstract::Electrophysiological data indicate that hyperglycemia is associated with decreased neural taste responsiveness to 1.0 M glucose, but not to 0.01 M quinine HCl, in the rat's hindbrain. The present behavioral experiment was conducted to determine whether this suppression of neural activity is manifested in a reduced int...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90081-3
更新日期:1987-01-01 00:00:00
abstract::The effect of oil enriched diets on sexual and exploratory behavior has been studied in male rats undernourished in utero and during lactation. At 20 days of age, for a period of 4 months, these animals were fed with 3 different diets: standard diet, standard diet enriched with 7% soybean oil, and standard diet enrich...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00150-9
更新日期:1997-07-01 00:00:00
abstract::Withdrawal from progesterone and estradiol has been used as an animal model of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). In the clinical population individual sensitivity to sex steroid hormones, personality and heredity influence PMS/PMDD. Understanding the phenotypic risk factors of PMS...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2008.08.015
更新日期:2009-01-08 00:00:00
abstract::Difficulty in initiating sleep is an important problem because it is associated with an increased incidence of depression, diabetes, myocardial infarction, and higher all-cause mortality. Although experimental studies in controlled settings have shown that warm skin temperature of the extremities (feet and hands) befo...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.05.022
更新日期:2015-10-01 00:00:00
abstract::Sucrose is considered by many to be detrimental to health, giving rise to deterioration of the body associated with ageing. This study was undertaken to determine whether replacing sucrose in the diet long-term with honey that has a high antioxidant content could decrease deterioration in brain function during ageing....
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2009.03.001
更新日期:2009-06-22 00:00:00
abstract:BACKGROUND:This cohort study evaluates whether the association between low-grade inflammation and incident depressive symptoms is independent of abdominal obesity and metabolic disturbances. METHODS:A cohort of 1167 non-depressed men aged 35 to 80 years were followed up over 5 years to assess incident depressive sympt...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2014.11.058
更新日期:2015-02-01 00:00:00
abstract::In a nutrient self-selection study, CAST/EiJ mice consumed more carbohydrate than fat while C57BL/6J (B6) mice showed the opposite preference. The present study revealed similar strain differences in preferences for isocaloric fat (Intralipid) and carbohydrate (sucrose, maltodextrin) solutions in chow-fed mice. In ini...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2018.06.018
更新日期:2018-10-01 00:00:00
abstract::Pigeons were exposed to fixed-time food schedules of 30, 120, and 480 sec with two reinforcer magnitudes at each. Attack behavior against a rear-projected conspecific image was assessed at each interfood/reinforcer magnitude combination. For seven of eight subjects, attack rate was related to interfood interval by an ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90140-y
更新日期:1990-02-01 00:00:00
abstract::Angiotensins, especially angiotensin IV (Ang IV), have recently been found to be potent cognitive enhancers in rodents. However, the precise mechanisms of their memory improving effects remain unknown. In this study we tested the hypothesis that D2 dopamine receptors at least partially mediate cognitive effects of Ang...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.03.025
更新日期:2006-06-15 00:00:00
abstract::Subjects consumed soup (beef consomme) preloads of a fixed size containing different concentrations of monosodium L-glutamate (MSG). Effects on appetite following these preloads, and when no soup was consumed, were assessed in 3 studies. The soups supplemented with MSG were rated as more "pleasant," more "savoury" and...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90230-2
更新日期:1990-12-01 00:00:00
abstract::Large meals scheduled at greater-than-circadian periods (such as T = 31 h) tend to elicit enhanced activity approximately 24 h subsequent to receipt. These studies characterized the process responsible for this meal-engendered "circadian ensuing activity" (meal CEA). Female Sprague-Dawley rats were housed in stations ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(98)00211-x
更新日期:1999-01-01 00:00:00
abstract::Brain derived neurotrophic factor (BDNF) is a protein that plays a critical role in modulating cognition in animals and humans. Aerobic exercise often increases BDNF in adults, but effects of this exercise modality and others among adolescents remain uncertain. This study examined the effects of aerobic training, resi...
journal_title:Physiology & behavior
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.physbeh.2018.04.026
更新日期:2018-07-01 00:00:00
abstract::Changes in thermal environment can invoke a stress response in pigs, which in turn can potentially impact their immune system and disease susceptibility. We investigated effects of heat stress and social rank on behavior, immune responsiveness, and performance of pigs challenged with porcine reproductive and respirato...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.08.029
更新日期:2007-01-30 00:00:00
abstract::Single and population-mean cosinor analyses document a circadian rhythm in salivary cortisol of pigs (p < 0.001). The midline estimated statistic of rhythm, the MESOR (M), is 1.50 +/- 0.07 ng/ml. For the group of 14 pigs studied there was a predictable variation of 64% around this mean in salivary cortisol within a da...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(96)00107-2
更新日期:1996-09-01 00:00:00
abstract::The role of olfactory input in the regulation of food intake and feeding patterns in rats was investigated by performing bilateral olfactory bulbectomy. Compared to control rats, bulbectomized rats ate the same amounts of food, but did so via a decrease in meal size, and a doubling in meal number. Although no increase...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(93)90238-b
更新日期:1993-09-01 00:00:00