Abstract：
:Sucrose is considered by many to be detrimental to health, giving rise to deterioration of the body associated with ageing. This study was undertaken to determine whether replacing sucrose in the diet long-term with honey that has a high antioxidant content could decrease deterioration in brain function during ageing. Forty-five 2-month old Sprague Dawley rats were fed ad libitum for 52 weeks on a powdered diet that was either sugar-free or contained 7.9% sucrose or 10% honey (which is the equivalent amount of sugar). Anxiety levels were assessed using an Elevated Plus Maze, whilst a Y maze and an Object Recognition task were used to assess memory. Locomotor activity was also measured using an Open Field task to ensure that differences in activity levels did not bias results in the other tasks. Anxiety generally decreased overall from 3 to 12 months, but the honey-fed rats showed significantly less anxiety at all stages of ageing compared with those fed sucrose. Honey-fed animals also displayed better spatial memory throughout the 12-month period: at 9 and 12 months a significantly greater proportion of honey-fed rats recognised the novel arm as the unvisited arm of the maze compared to rats on a sugar-free or sucrose-based diet. No significant differences among groups were observed in the Object Recognition task, and there appeared to be no differences in locomotor activity among groups at either 6 or 12 months. In conclusion, it appears that consumption of honey may reduce anxiety and improve spatial memory in middle age.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Chepulis LM,Starkey NJ,Waas JR,Molan PCdoi
10.1016/j.physbeh.2009.03.001subject
Has Abstractpub_date
2009-06-22 00:00:00pages
359-68issue
3-4eissn
0031-9384issn
1873-507Xpii
S0031-9384(09)00097-3journal_volume
97pub_type
杂志文章abstract：:Oxidative damage is one of the hallmarks of the aging process. The current study evaluated effects of two proprietary antioxidant-based ingredients, rosemary extract and spearmint extract containing carnosic acid and rosmarinic acid, respectively, on learning and memory in the SAMP8 mouse model of accelerated aging. T...
journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2012-12-05 00:00:00
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更新日期：1996-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90202-8
更新日期：1988-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2010.02.018
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pub_type： 临床试验,杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
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更新日期：1991-03-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2008-12-15 00:00:00
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更新日期：2009-08-04 00:00:00
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更新日期：2011-10-24 00:00:00
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journal_title：Physiology & behavior
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更新日期：2020-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1979-07-01 00:00:00
abstract：:The effects of stress on risk assessment behavior in mice were studied by examining latency to emerge from a safe compartment into a large, well-lit open field. In the first experiment different groups of mice were exposed for 1 h to tube restraint, fixed interval 2-min foot shock, or attack by an aggressive conspecif...
journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1996-04-01 00:00:00
abstract：:To support nipple attachment and huddling, rat pups must learn to approach and prefer maternal odor. Similar to other altricial species, rat pups have a sensitive period for learning this odor preference, which ends around postnatal day (PN) 10 and coincides with the emergence of walking. One characteristic of this se...
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更新日期：2003-01-01 00:00:00
abstract：:We investigated the acute effects of aerobic exercise with blood flow restriction (BFR) on mood state in American football athletes. Twenty-two male American football athletes were randomly assigned to three experimental conditions: 1) aerobic exercise (AE: 40% VO2max), 2) aerobic exercise with BRF (AE + BFR: 40% VO2 ...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
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更新日期：2019-11-01 00:00:00
