Pharmacological and anatomical aspects of cholinergic activation of female sexual behavior.

Abstract:

:Forebrain infusion of cholinergic agonists activated the sexual response, lordosis, in ovariectomized female rats that had been primed with a low dose of estrogen. Carbachol, an agonist with both muscarinic and nicotinic properties, and oxotremorine, an agonist with a primarily muscarinic action, produced dose-related increases in the frequency of lordosis elicited by stimulus male rats. This facilitation of lordosis was prevented when females were pretreated systemically with atropine or scopolamine, two muscarinic receptor antagonists. These results indicate that the effect of carbachol and oxotremorine on lordosis is mediated by cholinergic muscarinic receptors. The location of these receptors within the brain has not been identified. Ventricular infusion of carbachol was as effective as infusion directly into the medial preoptic area (POA) and more effective than infusion directly into the ventromedial hypothalamus (VMH). Furthermore, when carbachol or oxotremorine was delivered to the POA through cannulae angled to avoid traversing the lateral ventricles, no facilitation of lordosis was observed. These data suggest that muscarinic receptors stimulated by central infusion of cholinergic agonists may not be located in either the POA or the VMH, two regions traditionally implicated in the regulation of lordosis.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Dohanich GP,Barr PJ,Witcher JA,Clemens LG

doi

10.1016/0031-9384(84)90296-8

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

1021-6

issue

6

eissn

0031-9384

issn

1873-507X

pii

0031-9384(84)90296-8

journal_volume

32

pub_type

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