Problem-solving behaviour in apomorphine-susceptible and unsusceptible rats.

Abstract:

:Pharmacogenetically selected apomorphine-susceptible (APO-SUS) and apomorphine-unsusceptible (APO-UNSUS) rats were trained in a discrimination learning paradigm. After the initial discrimination task was solved, reinforcement contingencies were reversed. No differences between APO-SUS and APO-UNSUS animals were found in the rate of learning. However, negative transfer from the initial discrimination to its reversal was less for the APO-SUS rats than for the APO-UNSUS rats. Moreover, the APO-SUS rats responded more to the relevant dimension (light) than the APO-UNSUS rats in the last 100 trials before solving the initial problem as well as the reversal. During overtraining on the first problem, APO-SUS animals responded less to an irrelevant dimension (position of the lever) than APO-UNSUS animals. In the first 100 trials of the reversal APO-SUS rats responded more to another irrelevant dimension (noise) than APO-UNSUS rats. The data show that APO-SUS and APO-UNSUS rats used the various dimensions (visual, auditory, and spatial) differently in the chosen discrimination learning paradigm. It is concluded that the interline differences found are the consequences of the interline differences in the dopaminergic activity of the ventral and dorsal striatum.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Coenders CJ,Kerbusch SM,Vossen JM,Cools AR

doi

10.1016/0031-9384(92)90278-a

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

321-6

issue

2

eissn

0031-9384

issn

1873-507X

pii

0031-9384(92)90278-A

journal_volume

52

pub_type

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