Abstract：
:Olfactory bulbectomy (OBX) in rats produces behavioral, physiological, and neurochemical changes that resemble symptoms of depression in humans. The procedure thus serves as a rodent model of affective disorder. Many of the behavioral effects of OBX resemble psychomotor agitation. The possible role of dysregulation of ventral striatal dopamine (DA) systems in this phenomenon was investigated. Basal levels of DA, norepinephrine (NE), homovanillic acid, dihydroxyphenylacetic acid, and 5-hydroxyindoleacetic acid were examined in the striatum of OBX and sham-operated controls using in vivo microdialysis. OBX rats exhibited significantly higher basal DA levels (192%) and lower NE levels (12%) than sham-operated controls. Locomotor activity in response to novelty and footshock stress was elevated in OBX rats. The finding of higher DA levels in striatum may explain this "agitation-like" behavior, a commonly observed phenomenon in the OBX model.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Masini CV,Holmes PV,Freeman KG,Maki AC,Edwards GLdoi
10.1016/j.physbeh.2004.01.003subject
Has Abstractpub_date
2004-03-01 00:00:00pages
111-9issue
1eissn
0031-9384issn
1873-507Xpii
S0031938404000083journal_volume
81pub_type
杂志文章abstract：:Changes in phasic events in the elderly are reviewed. Such phasic events may in part be determined by the macrostructure of sleep (sleep stages). Therefore, a brief description of sleep architecture and EEG morphology in the aged person is given. Second, there is a marked variability among individuals in the number of...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2002-06-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：2014-01-30 00:00:00
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更新日期：1992-06-01 00:00:00
