Effect of chronic insulin administration on food intake and body weight in rats.

Abstract:

:Insulin was chronically administered to rats to determine its effect on the daily changes in food intake and body weight. Animals received regular insulin via 14-day osmotic minipumps in doses of 0.0, 0.5, 1.0, 3.0, and 5.0 IU/day treated either with (+GLU) or without glutamic acid (-GLU). Previous studies have shown that glutamic acid prevents insulin aggregation in the minipumps to provide a more stable flow rate. Food intake and body weights were measured each day of treatment. Chronic insulin treatment was ineffective in promoting changes in animals receiving any dose of insulin except the highest dose. Animals receiving 5.0 IU/day insulin + GLU experienced a transient hyperphagia and weight gain followed by a suppression in food intake and body weight by Day 4 of treatment. Effects were attenuated in animals receiving insulin -GLU. Plasma insulin concentrations on Day 14 were similar for all doses, suggesting a compensation took place either in insulin degradation or endogenous insulin production. Results indicate that glutamic acid treatment enhances the effects of chronic insulin administration via osmotic minipumps.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Destefano MB,Stern JS,Castonguay TW

doi

10.1016/0031-9384(91)90021-f

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

801-6

issue

4

eissn

0031-9384

issn

1873-507X

pii

0031-9384(91)90021-F

journal_volume

50

pub_type

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