Abstract：
:A binge drinking pattern of alcohol consumption has been shown to have an impact on brain structures that continue to develop into late adolescence. These same brain structures have been implicated in processing self-movement cues. The current study applies an array of existing and novel kinematic analysis techniques to characterize performance on manipulatory scale tasks to assess spatial orientation deficits associated with a history of adolescent binge drinking. Using kinematic analysis techniques, a history of adolescent binge drinking in university students was associated with disruptions in outward segment movement organization and less accurate direction and distance estimation in a dead reckoning task. Similar disruptions in performance were found in the bead maze task in the first training block; however, no group differences were observed on subsequent blocks of place training. This is the first study to demonstrate a relationship between adolescent binge drinking in humans and impaired processing of self-movement cues. This pattern of results demonstrates the potential of manipulatory-scale spatial tasks to detect differences in information processing associated with factors known to disrupt normal central nervous system development.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Blankenship PA,Blackwell AA,Ebrahimi N,Benson JD,Wallace DGdoi
10.1016/j.physbeh.2016.04.027subject
Has Abstractpub_date
2016-07-01 00:00:00pages
130-139eissn
0031-9384issn
1873-507Xpii
S0031-9384(16)30163-9journal_volume
161pub_type
杂志文章abstract：:Because most naturally occurring toxins taste bitter to humans, any mechanism that reduces the rate at which bitter substances are ingested and digested should be adaptive. Based on the recent discovery of T2R bitter taste receptors in the gastrointestinal tract of rodents, we asked whether intragastric (IG) infusion ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.11.029
更新日期：2008-03-18 00:00:00
abstract：:The sensation that humans describe as "bitter" is evoked by a large group of chemically diverse ligands. Bitter stimuli are avoided by a range of species and elicit reflex rejection, behaviors considered adaptations to the toxicity of many of these compounds. We review novel evidence for neurons that are narrowly tune...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2009.02.042
更新日期：2009-07-14 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.11.058
更新日期：2015-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00080-3
更新日期：1995-09-01 00:00:00
abstract：:Adult female mice were exposed to a combination of four anabolic-androgenic steroids for 9 weeks at doses that were either one or five times the androgenic maintenance level for male mice. Relative to control females, steroid treatment depressed gonadotropin secretion and increased both dry body weight and fat content...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02027-6
更新日期：1996-01-01 00:00:00
abstract：:Wrist motions (223-471)/5 min were measured during 17-32 days of continuous recordings made from human passengers as they traveled across zero to five time zones for business and pleasure. The travelers all exhibited daily cycles of activity and rest. The duration of daily activity, alpha, was 1.1 h less at the destin...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90088-4
更新日期：1994-05-01 00:00:00
abstract：:The effects of immediate posttraining subcutaneous administration of naloxone (0.25, 1 or 5 mg/kg) on retention behaviour of rats trained in an inhibitory avoidance task, subjected or not to familiarization with the training situation prior to the training trial (pretraining) have been investigated. Naloxone did not i...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90394-4
更新日期：1985-11-01 00:00:00
abstract：:The present experiment compared the strengths of taste aversion learning in rats induced by forced swimming in a water pool (5, 15, 30, or 60 min), voluntary running in an activity wheel (15, 30, 60, or 120 min), forced running in a motorized wheel (60 min at the speed of 8 m/min), optional running in the apparatus co...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.04.013
更新日期：2006-07-30 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(75)90288-7
更新日期：1975-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.02.007
更新日期：2007-05-16 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.05.063
更新日期：2007-11-23 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/s0031-9384(02)00898-3
更新日期：2002-12-01 00:00:00
abstract：:The effects of chronic estrogen withdrawal and subsequent hormone replacement on the feeding and body weight of adult lean and genetically obese Zucker rats were investigated. Following confirmation of a delay in the vaginal canalization of the fatty rat, subgroups of each genotype received either ovariectomy or sham ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(79)90130-6
更新日期：1979-07-01 00:00:00
abstract：:Previous studies are mainly focused on non-wooden environments, whereas few are concerned with wooden ones. How wooden indoor environments impact the physiology of the occupants is still unclear. The purpose of this study was to explore the distinct physiological responses to wooden and non-wooden indoor environments,...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.02.043
更新日期：2017-05-15 00:00:00
abstract：:The effects of an irreversible long term opioid antagonism on circadian rhythms in body temperature (Tb), locomotor activity (Act) and feeding under normal conditions and following lipopolysaccharide administration (LPS; 2.5 mg/kg) have been investigated in unrestrained mice housed at their thermoneutral zone (30 degr...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00067-s
更新日期：1995-08-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90063-l
更新日期：1993-07-01 00:00:00
abstract：:Despite some reports that aspartame (APM)-sweetened beverages may increase subjective appetite, previously we demonstrated that drinking 280 ml of an APM-sweetened soft drink (170 mg APM) had no effect on appetite, and 560 ml of the same soft drink (340 mg APM) reduced appetite. The present study examined this appetit...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0031-9384(93)90139-7
更新日期：1993-03-01 00:00:00
abstract：:The present study aimed to examine the effect of time-of-day on postural control, body temperature, and attentional capacities in 5-6 year old children. Twelve male children (5-6-year-old) were asked to maintain an upright bipedal stance on a force platform with eyes open (EO) and eyes closed (EC) at 07:00, 10:00, 14:...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.01.029
更新日期：2015-04-01 00:00:00
abstract：:Studies have found that, under a wide variety of social circumstances, females are more likely than males to smile. The present article offers a theoretical explanation for this difference based on the premise that testosterone (along with other sex hormones) has evolved the tendency to alter brain functioning in ways...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2006.03.034
更新日期：2006-07-30 00:00:00
abstract：:The palatability of food has been shown to influence the cephalic phase reflexes. To determine if food palatability affects the magnitude of cephalic phase insulin release (CPIR) in humans, normal-weight women were asked to list foods that they found palatable and unpalatable. Subjects then stayed overnight in the hos...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
doi：10.1016/s0031-9384(96)80033-3
更新日期：1996-08-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90373-1
更新日期：1984-10-01 00:00:00
abstract：:Food intake of four adult male baboons (Papio anubis), ranging in weight from 18 to 33 kg, was monitored during daily experimental sessions lasting 22 hours. Food was available under a two-component operant schedule designed to mimic food availability in the natural ecology. The first component was a "procurement" com...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90124-2
更新日期：1988-01-01 00:00:00
abstract：:The specific immune system is a protective mechanism that detects infection and fights it by production of antibodies. Newborns are especially susceptible to infections because their immune system is not yet as fully developed as that of adults. This has been well established in altricial mammals. Fighting infection i...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.04.008
更新日期：2005-06-02 00:00:00
abstract：:The effects of amphetamine (5-20 mg/kg) were studied 60 min after injection in mice aged 2, 3, 4 and 6 weeks postpartum. Exploratory behavior as indicated by the "head poke" test was depressed at all ages, but appeared to be relatively uncomplicated by other effects at the 5 mg/kg dose. At 4 and 6 weeks control female...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90261-1
更新日期：1986-01-01 00:00:00
abstract：:Psychological stress is associated with an increased expression of markers of peripheral inflammation, and there is a growing literature describing a link between periodontal pathogens and systemic inflammation. The hypothesis of the present work is that exposing mice to the social stressor, called social disruption (...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2009.06.013
更新日期：2009-09-07 00:00:00
abstract：:Female rats can show mounting behavior towards isosexual or heterosexual conspecifics. The present experiments were designed to study whether the prenatal presence of male fetuses would affect display of this mounting behavior in adulthood. Therefore mounting behavior, after gonadectomy and during continuous treatment...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90167-6
更新日期：1982-06-01 00:00:00
abstract：:Patients suffering from depression-associated cognitive impairments often recover incompletely after remission from the core symptoms of depression (lack of energy, depressed mood and anhedonia). This study aimed to set the basis for clinically relevant testing of cognitive impairments in a preclinical model of depres...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.11.010
更新日期：2018-02-01 00:00:00
abstract：:Mice adapted to drink a flavored saccharin solution (CS-) paired with intragastric (IG) self-infusions of water rapidly increase their intake of a new flavored solution (CS+) that is paired with IG glucose self-infusions. The present study extends this method to examine post-oral glucose appetition in rats. Food-restr...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.04.042
更新日期：2014-06-22 00:00:00
abstract：:Pharmacogenetically selected apomorphine-susceptible (APO-SUS) and apomorphine-unsusceptible (APO-UNSUS) rats were trained in a discrimination learning paradigm. After the initial discrimination task was solved, reinforcement contingencies were reversed. No differences between APO-SUS and APO-UNSUS animals were found ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90278-a
更新日期：1992-08-01 00:00:00
abstract：:Using a combination of injection cannula and recording electrode, the effect of 1 microliter of 3 mM verapamil upon the multiunit responses evoked in the peripeduncular nucleus (PPN) by electric stimuli applied to the pudendal nerves in urethane anesthetized proestrous female rats was studied in 9 experiments. It was ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90170-9
更新日期：1988-01-01 00:00:00
