Genetic obestiy: estrogenic influences on the body weight and food intake of lean and obese adult Zucker (fa/fa) rats.

Abstract:

:The effects of chronic estrogen withdrawal and subsequent hormone replacement on the feeding and body weight of adult lean and genetically obese Zucker rats were investigated. Following confirmation of a delay in the vaginal canalization of the fatty rat, subgroups of each genotype received either ovariectomy or sham surgery (Experiment 1). One hundred days later all subjects were injected subcutaneously (SC) with 1.0 microgram of estradiol benzoate (EB) daily for 16 treatment days (Experiment 2A). A second series of daily 2.0 microgram EB injections was administered intraperitoneally (IP) for 1 week (Experiment 2B). The first experiment revealed that ovariectomy produced overeating and similar weight gains in both genotypes. In the second experiment, SC hormone treatment completely reversed ovarian obesity in lean animals but failed to alter the food intake or weight gain of fatty rats. IP administration of EB depressed the feeding of fatty and lean animals to a comparable degree but a reduction in weight gain was observed only in the lean rats. These findings are discussed in light of current theories of estrogenic modulation of energy balance.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Gale SK,Van Itallie TB

doi

10.1016/0031-9384(79)90130-6

subject

Has Abstract

pub_date

1979-07-01 00:00:00

pages

111-20

issue

1

eissn

0031-9384

issn

1873-507X

pii

0031-9384(79)90130-6

journal_volume

23

pub_type

杂志文章
  • How are neuroticism and depression related to the psychophysiological stress response to acute stress in healthy older people?

    abstract::Neuroticism and depressive symptomatology have been related to a heightened and diminished physiological stress response, which may partly explain their negative relationship with health and wellbeing. Identifying factors that may increase disease vulnerability is especially relevant in older people, whose physiologic...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2016.01.015

    authors: Puig-Perez S,Villada C,Pulopulos MM,Hidalgo V,Salvador A

    更新日期:2016-03-15 00:00:00

  • Emotional & electroencephalographic responses during affective picture viewing after exercise.

    abstract::We examined the effects of 30 min of cycling exercise at a moderate intensity of 50% peak oxygen uptake, compared to 30 min of rest, on changes in emotional responses to pictorial foreground stimuli that reliably elicit unpleasant, neutral, and pleasant affect. Emotional responses were measured by self-reports of vale...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2006.10.001

    authors: Crabbe JB,Smith JC,Dishman RK

    更新日期:2007-02-28 00:00:00

  • The mechanism of 5-lipoxygenase in the impairment of learning and memory in rats subjected to chronic unpredictable mild stress.

    abstract:OBJECTIVES:To examine the mechanism of 5-lipoxygenase (5-LO) in the learning and memory dysfunction in rats subjected to chronic unpredictable mild stress (CUMS). METHODS:Eighty rats were divided into eight groups: the 0.5% sodium carboxymethyl cellulose solution (NaCMC)-treated group, empty vector (LV-Mock)-treated g...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2016.09.010

    authors: Luo Y,Kuang S,Xue L,Yang J

    更新日期:2016-12-01 00:00:00

  • Prenatal stress impairs memory function in the early development of male-offspring associated with the gaba function.

    abstract::Prenatal stress (PS) induces cognitive deficits, abnormal behavior patterns and physical impairments in offspring, which disturbs the developmental process. GABA systems play a key role in the brain development. The developmental trajectories are less understood although PS increases the expression of GABAAR in young ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.113184

    authors: Shang Y,Chen R,Li F,Zhang H,Wang H,Zhang T

    更新日期:2021-01-01 00:00:00

  • Prenatal stress potentiates stress-induced behavior and reduces the propensity to play in juvenile rats.

    abstract::We examined the hypothesis that prenatal stress potentiates defensive responsiveness which may interfere with the expression of appetitive behavioral activities. Sibling pairs of prenatally stressed and control juvenile rats were placed in an unfamiliar environment. The latency and frequency of social play, a sought-a...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90147-t

    authors: Takahashi LK,Haglin C,Kalin NH

    更新日期:1992-02-01 00:00:00

  • Human physiological responses to wooden indoor environment.

    abstract::Previous studies are mainly focused on non-wooden environments, whereas few are concerned with wooden ones. How wooden indoor environments impact the physiology of the occupants is still unclear. The purpose of this study was to explore the distinct physiological responses to wooden and non-wooden indoor environments,...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2017.02.043

    authors: Zhang X,Lian Z,Wu Y

    更新日期:2017-05-15 00:00:00

  • Leucaena leucocephala extract has estrogenic and antiestrogenic actions on female rat reproduction.

    abstract::Leucaena feed has been reported to cause disruptive effects on livestock reproduction, such as low calving percentages in cows, abortion in female goats and pigs, dead fetuses and fetal resorption in pregnant rats. In this study, the effects of Leucaena on different female reproductive variables were analyzed in two d...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.112683

    authors: Sergio RP,Susana RM,Alberto DJ,Socorro RM

    更新日期:2019-11-01 00:00:00

  • Effects of paradoxical sleep deprivation in the rabbit.

    abstract::The effects of nonpharmacologically-induced deprivation of paradoxical sleep for a 24 hour period were studied in rabbits. Response characteristics commonly associated with the deprivation procedure in other species were observed, as well as features apparently peculiar to the rabbit. Like other mammals, rabbits: (1) ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90352-5

    authors: Pivik RT,Bylsma FW,Cooper P

    更新日期:1986-01-01 00:00:00

  • Mediation of male mouse urine marking and aggression by the vomeronasal organ.

    abstract::The effects of vomeronasal organ removal (VNX) on male mouse urine marking and aggressive behaviors were investigated. In three different stimulus conditions VNX male marking rates were about half that of sham-operated males. Aggressive behavior was tested by pairing males with male-urine-swabbed castrate males. Only ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90300-8

    authors: Maruniak JA,Wysocki CJ,Taylor JA

    更新日期:1986-01-01 00:00:00

  • Frequency-response characteristics provide a functional separation between stimulation-bound feeding and self-stimulation.

    abstract::Many lateral hypothalamic electrodes that support self-stimulation also elicit feeding. Refractory period and conduction velocity estimates for the axons supporting these behaviors appear identical, suggesting that these behaviors may be elicited by stimulation of a common directly activated substrate. However, it is ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(90)90007-q

    authors: Waraczynski MA,Kaplan JM

    更新日期:1990-05-01 00:00:00

  • Consumption of electrolytes and quinine by mouse strains with different blood pressures.

    abstract::Daily fluid intakes were measured using two-bottle tests in female mice of inbred strains with high (BPH/2), normal (BPN/3) or low (BPL/1) blood pressure. The mice were offered a choice between water and different concentrations of NaCl (37.5-600 mM), KCl (1-400 mM), CaCl2 (1-100 mM) and quinine hydrochloride (0.003-1...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(98)00069-9

    authors: Bachmanov AA,Schlager G,Tordoff MG,Beauchamp GK

    更新日期:1998-06-01 00:00:00

  • Glucocorticoid response to forced exercise in laboratory house mice (Mus domesticus).

    abstract::We examined the time course and sex differences of the glucocorticoid response to forced, moderate-intensity treadmill exercise in outbred laboratory house mice. Mice (n = 64 total) were divided into eight groups, each of four males and four females, which were run on a motorized treadmill at 1.0 km/h for either 0, 2,...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00441-1

    authors: Coleman MA,Garland T Jr,Marler CA,Newton SS,Swallow JG,Carter PA

    更新日期:1998-01-01 00:00:00

  • Sex differences in the effects of voluntary activity on sucrose-induced obesity.

    abstract::Sedentary, adult rats of both sexes fed Purina chow and a 32% sucrose solution overate, gained excess weight and had higher Lee Indexes of obesity than control animals fed only Purina chow. The magnitude of these effects was similar in the males and females. Animals of both sexes fed the sucrose diet showed a slower r...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(82)90012-9

    authors: Hirsch E,Ball E,Godkin L

    更新日期:1982-08-01 00:00:00

  • Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain.

    abstract::The research literature suggests that oxidative stress and pro-inflammatory factors influence neurotrophins in vitro. However, there is insufficient information about their effects on exercise training conditions, especially during high intensity trainings. This study aimed to compare the effects of 6weeks of high int...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.04.012

    authors: Afzalpour ME,Chadorneshin HT,Foadoddini M,Eivari HA

    更新日期:2015-08-01 00:00:00

  • Postweaning social experience and adult aggression in rats.

    abstract::One group of male rats was reared continuously in small, stable colonies of three animals each during a ten-week period beginning when they were 46 days old. A second group of animals was also reared in small groups of three animals each but membership within these colonies was randomly changed at weekly intervals. Th...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(84)90373-1

    authors: Lore RK,Stipo-Flaherty A

    更新日期:1984-10-01 00:00:00

  • Effect of acute caffeine intake on hit accuracy and reaction time in professional e-sports players.

    abstract::Caffeine is considered a cognitive enhancer at low to moderate doses because it improves alertness, vigilance, attention, and reaction time. However, no previous investigation has assessed the effect of acute caffeine intake on e-sports-specific performance. The aim of this investigation was to determine the effect of...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.113031

    authors: Sainz I,Collado-Mateo D,Coso JD

    更新日期:2020-10-01 00:00:00

  • The role of motor activity in diet-induced obesity in C57BL/6J mice.

    abstract::Previous research in our laboratory has demonstrated that the C57BL/6J (B/6J) mouse has a predisposition to develop severe obesity if placed on a high-fat diet. In the present study we assessed the role of physical activity in this phenomenon. Obesity-prone B/6J and obesity-resistant A/J mice were placed on one of fou...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)02210-4

    authors: Brownlow BS,Petro A,Feinglos MN,Surwit RS

    更新日期:1996-07-01 00:00:00

  • Altered sensitivity to NMDA following developmental lead exposure in rats.

    abstract::Early Pb exposure is known to disrupt the development of the hippocampus and result in deficits in learning and memory capacities and altered seizure susceptibility. The excitatory amino acid, NMDA, is found in high concentrations in the hippocampus and has been implicated in learning and memory functions and seizure ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90398-l

    authors: Petit TL,LeBoutillier JC,Brooks WJ

    更新日期:1992-10-01 00:00:00

  • Taste aversion in rats induced by forced swimming, voluntary running, forced running, and lithium chloride injection treatments.

    abstract::The present experiment compared the strengths of taste aversion learning in rats induced by forced swimming in a water pool (5, 15, 30, or 60 min), voluntary running in an activity wheel (15, 30, 60, or 120 min), forced running in a motorized wheel (60 min at the speed of 8 m/min), optional running in the apparatus co...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2006.04.013

    authors: Masaki T,Nakajima S

    更新日期:2006-07-30 00:00:00

  • Water intake of Djungarian and Syrian hamsters treated with various dipsogenic stimuli.

    abstract::Djungarian and Syrian hamsters were found to exhibit robust water intake following water deprivation, and in response to hyperosmotic and hypovolumetric challenges to body fluids following injections of hypertonic NaCl and polyethylene glycol, respectively. Water intake was not stimulated following peripheral injectio...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(88)90388-5

    authors: Rowland NE

    更新日期:1988-01-01 00:00:00

  • Impaired drinking to angiotensin II after subdiaphragmatic vagotomy in rats.

    abstract::Rats received total bilateral subdiaphragmatic vagotomy and, one month later, were fitted with chronic intravenous or intracerebroventricular cannulas. The vagotomized rats showed much reduced drinking compared with controls during intravenous infusion of angiotensin II. Their drinking to intracerebroventricularly adm...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(80)90068-2

    authors: Rowland N

    更新日期:1980-06-01 00:00:00

  • Dietary interventions for autism spectrum disorder: New perspectives from the gut-brain axis.

    abstract::There is still controversy surrounding the effectiveness of dietary interventions for autism spectrum disorder (ASD), namely the gluten-free/casein free diet and the ketogenic diet. Additionally, as studies mainly investigated their impact on ASD symptoms and behaviors, much remains unknown about their mechanisms of a...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,评审

    doi:10.1016/j.physbeh.2018.07.014

    authors: Doenyas C

    更新日期:2018-10-01 00:00:00

  • Effects of stress during pregnancy on maternal behavior in mice.

    abstract::The effects of stress experienced during pregnancy and raising stressed offspring on maternal behavior were investigated in Swiss-Webster mice. Dams were either stressed or not stressed during pregnancy, and raised either prenatally stressed or nonstressed cross-fostered pups. Maternal behaviors such as grooming, nurs...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(00)00431-5

    authors: Meek LR,Dittel PL,Sheehan MC,Chan JY,Kjolhaug SR

    更新日期:2001-03-01 00:00:00

  • Partner preference: assessing the role of the female goat.

    abstract::For domestic ruminants, the male is thought to have the control over mate choice. The aim of this study was to assess the potential role the female goat plays in choosing a sexual partner. Approach frequency and proximity time to various social or sexual stimuli in a Y-maze apparatus were used as partner preference as...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2010.01.022

    authors: Margiasso ME,Longpre KM,Katz LS

    更新日期:2010-04-19 00:00:00

  • The effect of perinatal exposure to estrogens on the sexually dimorphic response to novelty.

    abstract::In this study we investigated the sexually dimorphic anxiety response to a novel environment in the absence of estrogens neonatally or in adulthood. There was a sexual dimorphism in the plus-maze test after the open-field test, females being more active and less anxious. In the absence of estrogens neonatally but not ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(94)90148-1

    authors: Leret ML,Molina-Holgado F,González MI

    更新日期:1994-02-01 00:00:00

  • Profound differences in fat versus carbohydrate preferences in CAST/EiJ and C57BL/6J mice: Role of fat taste.

    abstract::In a nutrient self-selection study, CAST/EiJ mice consumed more carbohydrate than fat while C57BL/6J (B6) mice showed the opposite preference. The present study revealed similar strain differences in preferences for isocaloric fat (Intralipid) and carbohydrate (sucrose, maltodextrin) solutions in chow-fed mice. In ini...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2018.06.018

    authors: Sclafani A,Vural AS,Ackroff K

    更新日期:2018-10-01 00:00:00

  • Cognitive function in outbred house mice after 22 weeks of drinking oxygenated water.

    abstract::Oxygen-enriched drinking water, which is increasingly sold worldwide, is claimed to "keep both the body and the mind healthy." However, currently there is no scientific evidence for such a statement. Therefore, we assessed the effect of 22 weeks of drinking oxygenated water on cognitive performance in healthy mice, us...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2007.02.007

    authors: Sommer AM,Bogusch C,Lerchl A

    更新日期:2007-05-16 00:00:00

  • Early trauma and adult obesity: is psychological dysfunction the mediating mechanism?

    abstract::Several studies have shown that physical and/or sexual abuse during childhood may lead to the development of obesity later in life. Despite these consistent findings, the mechanism for the increased risk of obesity following developmental trauma is unknown. It has been suggested that psychological dysfunction, includi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2009.08.010

    authors: D'Argenio A,Mazzi C,Pecchioli L,Di Lorenzo G,Siracusano A,Troisi A

    更新日期:2009-12-07 00:00:00

  • Untangling the effects of hunger, anxiety, and nausea on energy intake during intravenous cholecystokinin octapeptide (CCK-8) infusion.

    abstract::Infusions of cholecystokinin (CCK) may exert their effects on appetite by inducing feelings of nausea or anxiety. In this double blind, placebo controlled crossover study, the impact of these effects on appetite were examined. Fifteen male subjects received a 20 min i.v. infusion of cholecystokinin octapeptide (CCK-8)...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/s0031-9384(98)00169-3

    authors: Greenough A,Cole G,Lewis J,Lockton A,Blundell J

    更新日期:1998-11-15 00:00:00

  • Adrenal modulation of parental behavior in neonatally gonadectomized C57BL/6J male mice.

    abstract::C57BL/6J male mice ordinarily kill neonatal mouse pups even if they are rendered androgen deficient by neonatal castration. Experiment 1 showed that adrenalectomy during adult life significantly decreased the tendency of neonatally gonadectomized males to kill newborns. Experiment 2 demonstrated that testosterone expo...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(87)90092-8

    authors: Kinsley C,Svare B

    更新日期:1987-01-01 00:00:00