Graded levels of hemorrhage, thirst and angiotensin II in the rat.

Abstract:

:Hemorrhage was evaluated as a stimulus to drink in rats prepared with chronically implanted jugular cannulae and bled either 20, 30, 40 or 50 percent of their total blood volume. Hourly observations of water intake for 5 hr after hemorrhage revealed that the volume drunk was proportional to the degree of hemorrhage. Drinking induced by 20 percent hemorrhage did not differ significantly from control values, and intake was greatest and most persistent after 50 percent blood loss. The onset of maximal drinking at 1 hr after 40 percent hemorrhage was preceded by a twofold increase in plasma concentrations of angiotensin II. This is compatible with previous suggestions that angiotensin plays a role in hypovolemic thirst.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Russell PJ,Abdelaal AE,Mogenson GJ

doi

10.1016/0031-9384(75)90288-7

subject

Has Abstract

pub_date

1975-07-01 00:00:00

pages

117-9

issue

1

eissn

0031-9384

issn

1873-507X

pii

0031-9384(75)90288-7

journal_volume

15

pub_type

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