Abstract:
:The inferior colliculus (IC) is primarily involved in the processing of acoustic stimuli, including those emitted by prey and predators. The role of the central nucleus of the IC (CIC) in fear and anxiety has been suggested based on electrophysiological, behavioral and immunohistochemical studies. The reactivity of high-anxiety rats (HA) to diverse challenges is different from low-anxiety ones (LA). In humans and laboratory animals, pathological anxiety is often accompanied by heightened vigilance and alertness, hyperactivity of the amygdala (AM), and increased amplitude of the auditory evoked potentials (AEP) from the IC. This study aims to evaluate the influence of the inactivation of the central (CEA) and basolateral (BLA) nuclei of the amygdala, after local infusions of the full GABAA agonist muscimol (1nmol/0.2μl), on the AEP elicited in the CIC of rats tested under a learned fear state. Our results showed that both BLA and CEA inactivation change the expression of conditioned fear, in a paradigm using the context as the conditioned stimulus (CS). These changes are correlated to the innate anxiety levels of the animals. It is supposed that this shortcoming is in addition to the imbalance between the regulatory role of the top-down and bottom-up processes in the control of anxiety.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Nobre MJdoi
10.1016/j.physbeh.2013.05.007subject
Has Abstractpub_date
2013-06-13 00:00:00pages
80-7eissn
0031-9384issn
1873-507Xpii
S0031-9384(13)00148-0journal_volume
118pub_type
杂志文章abstract:BACKGROUND:There is no consensus about how resilience is related to the different types of stress such as daily or chronic stress and psychopathology. The main objective of this study is to evaluate the relationship between resilience and the different measures of stress such as perceived stress, chronic stress, life e...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2019.02.001
更新日期:2019-04-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00514-3
更新日期:1998-02-15 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2000-11-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:1997-09-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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更新日期:2014-04-22 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-06-13 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.09.012
更新日期:2008-01-28 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
pub_type: 杂志文章
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journal_title:Physiology & behavior
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pub_type: 杂志文章
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