Changes on auditory physiology in response to the inactivation of amygdala nuclei in high anxiety rats expressing learned fear.

Abstract:

:The inferior colliculus (IC) is primarily involved in the processing of acoustic stimuli, including those emitted by prey and predators. The role of the central nucleus of the IC (CIC) in fear and anxiety has been suggested based on electrophysiological, behavioral and immunohistochemical studies. The reactivity of high-anxiety rats (HA) to diverse challenges is different from low-anxiety ones (LA). In humans and laboratory animals, pathological anxiety is often accompanied by heightened vigilance and alertness, hyperactivity of the amygdala (AM), and increased amplitude of the auditory evoked potentials (AEP) from the IC. This study aims to evaluate the influence of the inactivation of the central (CEA) and basolateral (BLA) nuclei of the amygdala, after local infusions of the full GABAA agonist muscimol (1nmol/0.2μl), on the AEP elicited in the CIC of rats tested under a learned fear state. Our results showed that both BLA and CEA inactivation change the expression of conditioned fear, in a paradigm using the context as the conditioned stimulus (CS). These changes are correlated to the innate anxiety levels of the animals. It is supposed that this shortcoming is in addition to the imbalance between the regulatory role of the top-down and bottom-up processes in the control of anxiety.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Nobre MJ

doi

10.1016/j.physbeh.2013.05.007

subject

Has Abstract

pub_date

2013-06-13 00:00:00

pages

80-7

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(13)00148-0

journal_volume

118

pub_type

杂志文章
  • Relationship between resilience and stress: Perceived stress, stressful life events, HPA axis response during a stressful task and hair cortisol.

    abstract:BACKGROUND:There is no consensus about how resilience is related to the different types of stress such as daily or chronic stress and psychopathology. The main objective of this study is to evaluate the relationship between resilience and the different measures of stress such as perceived stress, chronic stress, life e...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.02.001

    authors: García-León MÁ,Pérez-Mármol JM,Gonzalez-Pérez R,García-Ríos MDC,Peralta-Ramírez MI

    更新日期:2019-04-01 00:00:00

  • Taste dimensions of monosodium glutamate (MSG) in a food system: role of glutamate in young American subjects.

    abstract::Freshly cooked chicken broth was prepared with several concentrations (0.06-0.32 M) of added NaCl. In the first study, subjects were presented with pairs of samples, each having the same concentration of NaCl (salt) but one of which contained 0.01 M monosodium glutamate (MSG). The subjects preferred the sample with ad...

    journal_title:Physiology & behavior

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0031-9384(98)00160-7

    authors: Okiyama A,Beauchamp GK

    更新日期:1998-08-01 00:00:00

  • Differences in localization of substantia nigra vs interaural line in Wistar and Sprague Dawley rats.

    abstract::The position of substantia nigra anterior to the interaural line has been correlated with body weight in Wistar rats. A regression line y = 0.0050x + 1.36 makes it possible to locate the substantia nigra in different sized rats ranging between 140 g and 460 g. This equation is not valid for Sprague Dawley rats. The po...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(82)90075-0

    authors: Skarsfeldt T

    更新日期:1982-02-01 00:00:00

  • Exploratory and displacement behavior in transgenic mice expressing high levels of brain TNF-alpha.

    abstract::Studies reported recently have shown that tumor necrosis factor-alpha (TNF-alpha) a cytokine released by macrophages and monocytes plays a key role in inflammatory processes and immune and neuro-endocrine regulation. TNF-alpha is also produced in the central nervous system (CNS). However, the role of this cytokine in ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00514-3

    authors: Fiore M,Alleva E,Probert L,Kollias G,Angelucci F,Aloe L

    更新日期:1998-02-15 00:00:00

  • Dried bonito dashi: Contributions of mineral salts and organic acids to the taste of dashi.

    abstract::Dried bonito dashi is often used in Japanese cuisine with a number of documented positive health effects. Its major taste is thought to be umami, elicited by inosine 5'-monophosphate (IMP) and L-amino acids. Previously we found that lactic acid, a major component of dried bonito dashi, enhanced the contribution of man...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2018.11.016

    authors: Delay ER,Weaver B,Lane DR,Kondoh T

    更新日期:2019-02-01 00:00:00

  • Assessment of mouse anxiety-like behavior in the light-dark box and open-field arena: role of equipment and procedure.

    abstract::Light-dark box and open field are conventional tests for assessment of anxiety-like behavior in the laboratory mice, based on approach-avoidance conflict. However, except the basic principles, variations in the equipment and procedures are very common. Therefore, contribution of certain methodological issues in differ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2014.05.006

    authors: Kulesskaya N,Voikar V

    更新日期:2014-06-22 00:00:00

  • Antidepressants suppress bulbectomy-induced augmentation of voluntary alcohol consumption in C57B1/6j but not in DBA/2j mice.

    abstract::Bulbectomy has been previously shown to produce the specific antidepressant-sensitive syndrome in C57Bl/6j, but not DBA/2j mice. The present study examined the effect of the depression on voluntary alcohol consumption. Alcohol consumption and alcohol preference (% of alcohol solution in total liquid) in a free-choice,...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(94)90293-3

    authors: Katkov YA,Otmakhova NA,Gurevich EV,Nesterova IV,Bobkova NV

    更新日期:1994-09-01 00:00:00

  • Responses to novel odors mediate maternal behavior and concaveation in gerbils.

    abstract::In a series of three experiments we examined: (Experiment 1) responses to novel odors by early- and late-maturing not-pregnant, pregnant, nursing and postweaning female Mongolian gerbils, (Experiment 2) the response of the same eight groups of female gerbils to unfamiliar pups, and (Experiment 3) the rate of induction...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90441-5

    authors: Clark MM,Spencer CA,Galef BG Jr

    更新日期:1986-01-01 00:00:00

  • A simple device for experimentally concussing the rat.

    abstract::A device is described for eliciting acceleration concussion in the awake rat. Animals, which were manually restrained, were struck on the occipital crest by a rubber knob attached to the striker wire of a spring-loaded rat trap. This method produced concussion with survival in over 50% of animals tested. The remainder...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(85)90154-4

    authors: Shaw NA

    更新日期:1985-10-01 00:00:00

  • Short latency induction of lordosis by ether in estrogen-primed female rats.

    abstract::Brief ether exposure induced high quality sexual receptivity in ovariectomized, estrogen-treated rats, presumably by increasing the secretion of adrenal progestins. Adrenalectomy completely blocked the effects of ether on this behavior. The onset of receptivity occurred 30--60 min following ether exposure; latencies m...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(77)90333-x

    authors: Franck JA

    更新日期:1977-08-01 00:00:00

  • Feeding status and basking requirements of freshwater turtles in an invasion context.

    abstract::Thermoregulatory behavior and feeding status are strongly related in ectotherms. A trade-off between maintenance of energy balance and digestion efficiency has been recently proposed to affect thermoregulation in these animals. On the other hand, competition for basking sites has been described between Iberian turtles...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2011.12.020

    authors: Polo-Cavia N,López P,Martín J

    更新日期:2012-03-20 00:00:00

  • The effect of social environment on the immune response of female common voles in matriarchal laboratory groups.

    abstract::We used the hemagglutination test to investigate differences in the specific immune response to sheep red blood cells (SRBC) of female common voles living in matriarchal groups. The applied test proved to be a useful tool for studying the effect of the social environment on the immune response in small mammals. The re...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(00)00332-2

    authors: Heise SR,Van Acker A

    更新日期:2000-11-01 00:00:00

  • Functional relationship between the hypothalamic vigilance area and PAG vigilance area.

    abstract::The vigilance reaction is characterized by a large bradycardia, a pressor response, and inspiratory apnea in anesthetized rabbits and the inhibition of movement in conscious rabbits. This affective response pattern can be elicited by electrical stimulation of the dorsolateral hypothalamus (the hypothalamic vigilance a...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00004-8

    authors: Duan YF,Winters R,McCabe PM,Green EJ,Huang Y,Schneiderman N

    更新日期:1997-09-01 00:00:00

  • Neonatal infection modulates behavioral flexibility and hippocampal activation on a Morris Water Maze task.

    abstract::Neonatal infection has enduring effects on the brain, both at the cellular and behavioral levels. We determined the effects of peripheral infection with Escherichia coli at postnatal day (P) 4 in rats on a water maze task in adulthood, and assessed neuronal activation in the dentate gyrus (DG) following the memory tes...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2014.02.033

    authors: Williamson LL,Bilbo SD

    更新日期:2014-04-22 00:00:00

  • Effects of light stimulation on the activity of the autonomic nerves in anesthetized rats.

    abstract::The existence of the retino-hypothalamic pathway suggests that light stimulation may influence the activity of the autonomic outflows. Efferent activities of the pancreatic, hepatic, and gastric branches of the vagus nerve and those of pancreatic, hepatic, splenic, adrenal, and renal branch of the splanchnic nerve wer...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(93)90249-f

    authors: Niijima A,Nagai K,Nagai N,Akagawa H

    更新日期:1993-09-01 00:00:00

  • Enhanced voluntary wheel running in GPRC6A receptor knockout mice.

    abstract::GPRC6A is an amino acid-sensing receptor highly expressed in the brain and in skeletal muscle. Although recent evidence suggests that genetically engineered GPRC6A receptor knockout (KO) mice are susceptible to develop subtle endocrine and metabolic disturbances, the underlying disruptions in energy metabolism are lar...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2013.05.015

    authors: Clemmensen C,Pehmøller C,Klein AB,Ratner C,Wojtaszewski JF,Bräuner-Osborne H

    更新日期:2013-06-13 00:00:00

  • Experimental study on physiological responses and thermal comfort under various ambient temperatures.

    abstract::This study mainly explored the thermal comfort from the perspective of physiology. Three physiological parameters, including skin temperature (local and mean), electrocardiograph (ECG) and electroencephalogram (EEG), were investigated to see how they responded to the ambient temperature and how they were related to th...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2007.09.012

    authors: Yao Y,Lian Z,Liu W,Shen Q

    更新日期:2008-01-28 00:00:00

  • Progesterone inhibition of sexual behavior is accompanied by an activation of aggression in female Syrian hamsters.

    abstract::Previous studies have shown that progesterone can have biphasic activational and inhibitory roles in the regulation of sexual behavior in female Syrian hamsters. The purpose of this study was to determine whether these biphasic effects on sexual behavior are mirrored in a reciprocal regulation of aggression. Ovariecto...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(90)90102-a

    authors: Meisel RL,Sterner MR

    更新日期:1990-03-01 00:00:00

  • Long- and short-term habituation of acoustic startle is not frequency specific in the rat.

    abstract::Two experiments examined the frequency specificity of habituation of the acoustic startle response in the rat. Following the long-term habituation of startle to one of two pure tone stimuli in Experiment 1, animals were presented with the other stimulus. Startle response asymptotes were unaffected by this change in st...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00512-x

    authors: Jordan WP,Poore LH

    更新日期:1998-02-15 00:00:00

  • Malaise can condition avoidance of high-viscosity fluids.

    abstract::Previous researchers have assumed that malaise-inducing drugs condition aversions to tastes more readily than to textural stimuli. The present report shows that rats given a single injection of lithium chloride after they have sampled a viscous fluid, subsequently showed greater avoidance of that fluid than did contro...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90373-a

    authors: Ramirez I

    更新日期:1992-11-01 00:00:00

  • Ondansetron interferes with unconditioned lying-on belly and acquisition of conditioned gaping induced by LiCl as models of nausea-induced behaviors in rats.

    abstract::Rats selectively display conditioned gaping reactions when re-exposed to flavours previously paired with nausea-inducing treatments and drugs that reduce nausea also reduce these reactions, suggesting that they represent a model of nausea-induced behavior in rats. However, these reactions rely upon learning, they are ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2011.10.017

    authors: Tuerke KJ,Winters BD,Parker LA

    更新日期:2012-02-01 00:00:00

  • Sucrose-conditioned flavor preferences in sweet ageusic T1r3 and Calhm1 knockout mice.

    abstract::The present study compared the ability of sweet ageusic T1r3 knockout (KO) and Calhm1 KO mice to acquire preferences for a sucrose-paired flavor as well as for unflavored sucrose. The KO and wildtype (WT) mice were given 24-h one-bottle access to 8% sucrose containing one flavor CS+, e.g., grape) and to water containi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2013.12.003

    authors: Sclafani A,Marambaud P,Ackroff K

    更新日期:2014-03-14 00:00:00

  • Effects of early separation of young rats from the mother on their open-field behavior.

    abstract::Changes were studied in the open-field behavior of young rats prematurely separated from their mothers at different ages. Premature separation from the mother on days 15 and 18 of life increased their fear or emotional behavior, as measured by the amount of defecation and locomotor activity. The changes in rats' open-...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(87)90272-1

    authors: Janus K

    更新日期:1987-01-01 00:00:00

  • Workshop on taste and smell in the elderly: an overview.

    abstract::The purpose of the workshop entitled Taste and Smell in the Elderly: Behavioral and Nutritional Consequences was 1) to review the current state of knowledge in the area of taste and smell, with emphasis on age-related changes, 2) to identify existing gaps in our knowledge, and 3) to develop future research strategies....

    journal_title:Physiology & behavior

    pub_type:

    doi:10.1016/s0031-9384(98)00261-3

    authors: Finkelstein JA,Schiffman SS

    更新日期:1999-04-01 00:00:00

  • Sucrose and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: Role of BDNF and β-endorphin.

    abstract::Pain in neonates is associated with short and long-term adverse outcomes. Data demonstrated that long-term consequences of untreated pain are linked to the plasticity of the neonate's brain. Sucrose is effective and safe for reducing painful procedures from single events. However, the mechanism of sucrose-induced anal...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2017.06.015

    authors: Nuseir KQ,Alzoubi KH,Alhusban A,Bawaane A,Al-Azzani M,Khabour OF

    更新日期:2017-10-01 00:00:00

  • Assessing odor generalization in the rat: a sensitive technique.

    abstract::In investigating the ability of the rat to discriminate among urine odors from mice of different genetic strains, we developed a technique for determining the extent of odor generalization. Trained rats performed a discrete trial, go/no-go procedure, touching a bar in the presence of an S+ odor for water reward. Rats ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90357-8

    authors: Duncan HJ,Beauchamp GK,Yamazaki K

    更新日期:1992-09-01 00:00:00

  • Predator odor exposure increases food-carrying behavior in rats.

    abstract::To cover their energy demands, prey animals are forced to search for food. However, during foraging they also expose themselves to the risk of becoming the prey of predators. Consequently, in order to increase their fitness foraging animals have to trade-off efficiency of foraging against the avoidance of predation ri...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.11.005

    authors: Wernecke KE,Brüggemann J,Fendt M

    更新日期:2016-02-01 00:00:00

  • Penile mechanisms and the role of the striated penile muscles in penile reflexes.

    abstract::Gross and subgross anatomical observations of the penis pointed to a mechanical arrangement whereby contraction of the bulbocavernosus (BC) muscles would enhance erections of the glans penis and contraction of the ischiocavernosus (IC) muscles would enhance or produce penis flips. These functions for the muscles were ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(83)90277-9

    authors: Hart BL,Melese-D'Hospital PY

    更新日期:1983-12-01 00:00:00

  • Participation of the CNS in the control of FFA mobilization during fasting in rabbits.

    abstract::The presence of FFA-mobilizing areas in the rabbit central nervous system was investigated by injecting minute amounts of 2-deoxyglucose, glucose or insulin directly into the cerebrospinal fluid of conscious, unrestrained rabbits. Intracerebroventricular administration of minute amounts (10 mg) of deoxyglucose to fed ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(90)90109-h

    authors: Paschoalini MA,Migliorini RH

    更新日期:1990-03-01 00:00:00

  • Entrainment of anticipatory activity to various durations of food access.

    abstract::Rats with lesions of the suprachiasmatic nuclei (SCN) and intact rats were maintained on restricted feeding with the duration of food access ranging from 4 to 12 hr. All rats with SCN lesions displayed at least some anticipatory activity (AA) at all food access durations. The amount of AA diminished when food access w...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(89)90359-4

    authors: Stephan FK,Becker G

    更新日期:1989-10-01 00:00:00