Intracerebroventricular cholecystokinin A-receptor antagonist does not reduce satiation by endogenous CCK.

Abstract:

:Suppression of sham feeding by exogenous CCK-8 or intraintestinal oleate infusion is attenuated by peripheral administration of the CCK-A receptor antagonist, devazepide, but not by the CCK-B antagonist, L365260. Likewise, systemically administered devazepide increases food intake by real feeding rats. These results suggest that endogenous CCK participates in the reduction of food intake by intestinal oleate and ingested food. Although originally categorized as a "peripheral" receptor subtype, the CCK-A receptor is also present in the brain. In an effort to examine whether devazepide acts in the brain or in the periphery to attenuate suppression of food intake by intraintestinal oleate, we injected devazepide into the lateral or fourth cerebral ventricles of intraintestinally infused, sham-fed rats. We also compared the ability of intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) devazepide to elicit increased food intake in real feeding rats. Doses of devazepide that were sufficient to attenuate or abolish oleate-induced suppression of sham feeding, when administered i.p., failed to attenuate suppression of intake when administered i.c.v., i.p. devazepide also was more effective than i.c.v. devazepide for attenuation of the suppression of sham feeding by i.p. injection of exogenous CCK-8. Finally, i.c.v. devazepide was ineffective for increasing real food intake, whereas the same dose administered i.p. significantly increased food intake. Our results do not support participation of brain CCK-A receptors in the suppression of food intake by exogenous CCK, or by endogenous CCK released after intraintestinal oleate infusion, or food intake.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Brenner LA,Ritter RC

doi

10.1016/s0031-9384(97)00519-2

subject

Has Abstract

pub_date

1998-02-15 00:00:00

pages

711-6

issue

4

eissn

0031-9384

issn

1873-507X

pii

S0031938497005192

journal_volume

63

pub_type

杂志文章
  • A physiological characterization of the Cafeteria diet model of metabolic syndrome in the rat.

    abstract::Many promising findings from pre-clinical research have failed to translate to the clinic due to their inability to incorporate human disease co-morbidity. A variety of rodent diets and feeding durations are currently used in models of human metabolic syndrome, obesity and diabetes. One model, the Cafeteria (CAF) diet...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2016.09.029

    authors: Gomez-Smith M,Karthikeyan S,Jeffers MS,Janik R,Thomason LA,Stefanovic B,Corbett D

    更新日期:2016-12-01 00:00:00

  • Relationship between resilience and stress: Perceived stress, stressful life events, HPA axis response during a stressful task and hair cortisol.

    abstract:BACKGROUND:There is no consensus about how resilience is related to the different types of stress such as daily or chronic stress and psychopathology. The main objective of this study is to evaluate the relationship between resilience and the different measures of stress such as perceived stress, chronic stress, life e...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.02.001

    authors: García-León MÁ,Pérez-Mármol JM,Gonzalez-Pérez R,García-Ríos MDC,Peralta-Ramírez MI

    更新日期:2019-04-01 00:00:00

  • Ondansetron interferes with unconditioned lying-on belly and acquisition of conditioned gaping induced by LiCl as models of nausea-induced behaviors in rats.

    abstract::Rats selectively display conditioned gaping reactions when re-exposed to flavours previously paired with nausea-inducing treatments and drugs that reduce nausea also reduce these reactions, suggesting that they represent a model of nausea-induced behavior in rats. However, these reactions rely upon learning, they are ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2011.10.017

    authors: Tuerke KJ,Winters BD,Parker LA

    更新日期:2012-02-01 00:00:00

  • Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine.

    abstract::Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine. These rats displayed enhanced intragroup aggression but normal muricide; gustatory neophobia and conditioned taste aversion were virtually el...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(93)90261-d

    authors: Persinger MA,Bureau YR,Kostakos M,Peredery O,Falter H

    更新日期:1993-05-01 00:00:00

  • Impaired social motivation and increased aggression in rats subchronically exposed to phencyclidine.

    abstract::Phencyclidine (PCP) treatment induces social withdrawal in the rat model of schizophrenia but little is known about the qualitative adequacy of behaviors displayed during interactions. Affiliative, avoidance, and aggressive behaviors were examined in rats 20 h after the 1st, the 8th, and the 15th injection of 10 mg/kg...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2008.11.002

    authors: Audet MC,Goulet S,Doré FY

    更新日期:2009-03-02 00:00:00

  • The use of hypothermia in surgical pinealectomy of the neonate rat.

    abstract::A technique is described in which rat pups (5-7 days old) are induced into a state of suspended animation by placing them in the freezing compartment of a refrigerator at -20 degrees C for 8-10 minutes. This induces cessation of respiration and heart beat for 12-15 minutes. Surgical pinealectomy is undertaken during t...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(89)90088-7

    authors: Cairncross KD,Parks AA,Everitt AV,Destefanis P,Maxwell CA

    更新日期:1989-03-01 00:00:00

  • The physio-metabolic effects of time-restricting liquid sugar intake to six-hour windows during the mouse active phase: The effects of active phase liquid sugar consumption.

    abstract::Obesity is a major public health concern and overconsumption of unhealthy fats and sugary beverages are contributing factors. Time-restricted feeding can reduce obesity-associated pathophysiological parameters by limiting the time of food consumption; however, the effects of time-restricted sugary water consumption ar...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.112905

    authors: Woodie LN,Neinast CE,Haynes W,Ahmed B,Graff EC,Greene MW

    更新日期:2020-09-01 00:00:00

  • Peripheral temperature drop in response to anticipation and consumption of a signaled palatable reward in laying hens (Gallus domesticus).

    abstract::The present study describes effects of anticipation and consumption of a palatable reward on comb surface temperature. The purpose was to investigate temperature responses as a potential physiological indicator of positive emotional states in laying hens. A rise in body temperature in response to stimuli predictive of...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2012.03.032

    authors: Moe RO,Stubsjøen SM,Bohlin J,Flø A,Bakken M

    更新日期:2012-06-25 00:00:00

  • A differential sex effect of amphetamine on exploratory behavior in maturing mice.

    abstract::The effects of amphetamine (5-20 mg/kg) were studied 60 min after injection in mice aged 2, 3, 4 and 6 weeks postpartum. Exploratory behavior as indicated by the "head poke" test was depressed at all ages, but appeared to be relatively uncomplicated by other effects at the 5 mg/kg dose. At 4 and 6 weeks control female...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90261-1

    authors: Goodrich C,Lange J

    更新日期:1986-01-01 00:00:00

  • The effects of caffeine on memory for word lists.

    abstract::The present study investigated the effects of caffeine on memory for supraspan word lists. Twelve groups of male and female college students classified as high or low impulsive were administered (PO) 0 mg/kg, 2 mg/kg or 4 mg/kg of caffeine. Subjects listened to four word lists presented at a fast rate and four at a sl...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(85)90170-2

    authors: Erikson GC,Hager LB,Houseworth C,Dungan J,Petros T,Beckwith BE

    更新日期:1985-07-01 00:00:00

  • Perceptual responses: Clinical versus practical blood flow restriction resistance exercise.

    abstract::The purpose of the current investigation was to compare the acute perceptual responses during low-load resistance exercise (RE) with clinical blood flow restriction (cBFR-RE) and practical blood flow restriction (pBFR-RE), and during conventional low- (LL-RE) and high-load resistance exercise (HL-RE), to determine if ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.113137

    authors: Miller RM,Galletti BAR,Koziol KJ,Freitas EDS,Heishman AD,Black CD,Larson DJ,Bemben DA,Bemben MG

    更新日期:2020-12-01 00:00:00

  • Behavioral effects of LPS in adult, middle-aged and aged mice.

    abstract::Acute infections lead to alterations in behavior, collectively known as sickness behavior, which includes reduction in locomotion, food ingestion, sexual and social behavior, environmental exploration, and sleep profile. Although generally seen as undesired, sickness behavior represents a conserved strategy for animal...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2008.10.018

    authors: Kinoshita D,Cohn DW,Costa-Pinto FA,de Sá-Rocha LC

    更新日期:2009-02-16 00:00:00

  • Effects of adaptation and cross-adaptation to common ions on sourness intensity.

    abstract::The effects of self and cross-adaptation of acetic acid and HCl solutions on the perception of sourness, were investigated using a filter paper method. In contrast to acetic acid and to pH-buffered acetic acid solutions, self-adaptation could not be obtained with HCl. In fact the sourness of the HCl test-stimulus afte...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(87)90111-9

    authors: Ganzevles PG,Kroeze JH

    更新日期:1987-01-01 00:00:00

  • Alcohol alliesthesia: food restriction increases the palatability of alcohol through a corticosterone-dependent mechanism.

    abstract::The present article analyzed the dramatic increase in alcohol ingestion that is known to occur in laboratory rats subjected to food restriction. In the first experiment, we wished to know when during the day food restricted animals consume the "extra" alcohol ration. Determinations of ethanol drinking at 3-h intervals...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(99)00078-5

    authors: Söderpalm AH,Hansen S

    更新日期:1999-09-01 00:00:00

  • A new neurometric dissection of the area-under-curve-associated jiggle of the motor evoked potential induced by transcranial magnetic stimulation.

    abstract:OBJECTIVE:The jiggle of the motor evoked potential (MEP) induced by transcranial magnetic stimulation (TMS) depends on a number of factors including the assessment of this stochastic signal by the method known as area under curve (AUC). We aim to ascertain the MEP findings assessed by the AUC method obtained from indiv...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2015.01.014

    authors: Leon-Sarmiento FE,Rizzo-Sierra CV,Leon-Ariza JS,Leon-Ariza DS,Sobota R,Prada DG

    更新日期:2015-03-15 00:00:00

  • Relationship between hyponeophagia and adrenal cortex function in farmed foxes.

    abstract::The adrenal cortex function of farmed blue (Alopex lagopus) and silver foxes (Vulpes vulpes) differing in their reaction in the feeding test were assessed. The urine cortisol:creatinine ratio was lower for those animals eating in the feeding test in comparison to those not eating in both species. In addition, eater si...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(98)00232-7

    authors: Rekilä T,Harri M,Jalkanen L,Mononen J

    更新日期:1999-01-01 00:00:00

  • Effects of macular xanthophyll supplementation on brain-derived neurotrophic factor, pro-inflammatory cytokines, and cognitive performance.

    abstract:PURPOSE:Oxidative and inflammatory processes play a major role in stress-induced neural atrophy. There is a wide body of literature linking oxidative and inflammatory stress with reductions in neurotrophic factors, stress resilience, and cognitive function. Based on their antioxidant and anti-inflammatory capacity, we ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.physbeh.2019.112650

    authors: Stringham NT,Holmes PV,Stringham JM

    更新日期:2019-11-01 00:00:00

  • Schisantherin A recovers Aβ-induced neurodegeneration with cognitive decline in mice.

    abstract::Schisantherin A (STA) is a main bioactive lignan isolated from Schisandra chinensis (Turcz.) Baill., which has been widely used as a tonic in traditional Chinese medicine for many years. Lots of studies have reported that STA exhibited anti-inflammatory and antioxidant effects. This paper was designed to investigate t...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2014.04.046

    authors: Li X,Zhao X,Xu X,Mao X,Liu Z,Li H,Guo L,Bi K,Jia Y

    更新日期:2014-06-10 00:00:00

  • The pituitary potential for opportunistic breeding in the Cape dune mole-rat, Bathyergus suillus.

    abstract::In this paper we investigated the effect of sex and season on baseline and post-GnRH challenge luteinising hormone (LH) levels in a solitary, seasonally breeding mole-rat. Circulating basal concentrations of luteinising hormone (LH) were found to differ significantly with season in both sexes. However, no significant ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2006.05.020

    authors: Hart L,O'Riain MJ,Jarvis JU,Bennett NC

    更新日期:2006-07-30 00:00:00

  • Metabolic fuel availability influences thermoregulation in deer mice (Peromyscus maniculatus).

    abstract::Body temperature (Tb) was monitored telemetrically in adult deer mice kept in an environmental chamber at low ambient temperature (Ta = 15 degrees C). Mice were challenged with various doses of 2-deoxy-D-glucose (2DG, a glycolysis inhibitor) or mercaptoacetate (MA, a fatty acid oxidation inhibitor) or a combination of...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(96)00495-7

    authors: Stamper JL,Dark J

    更新日期:1997-04-01 00:00:00

  • Effects of feeding and light cycles on activity rhythms of maternally isolated rat pups.

    abstract::Motor activity of infant rat pups was measured continuously between days 3 and 18 of postnatal age. Mother-reared rats on a 12:12 LD cycle exhibited significant rhythmic activity in the circadian range as early as day 5 of postnatal age. Some of the pups reared in isolation from maternal and sibling contact and kept o...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(87)90006-0

    authors: Anderson VN,Smith GK

    更新日期:1987-01-01 00:00:00

  • Repeated gastric distension alters food intake and neuroendocrine profiles in rats.

    abstract::The consumption of a large food bolus leads to stomach distension. Gastric distension potently signals the termination of a meal by stimulating gastric mechanoreceptors and activating neuroendocrine circuitry. The ability to terminate a meal is altered in disorders such as bulimia nervosa (BN), binge-eating disorder (...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2011.11.006

    authors: Hargrave SL,Kinzig KP

    更新日期:2012-02-28 00:00:00

  • Maternal diet influences reproductive development in male prairie vole offspring.

    abstract::The plant compound, 6-methoxy-2-benzoxazolinone (6-MBOA), is found in the meristematic tissue of young, vegetatively growing grasses, and its ingestion stimulates the reproductive system of rodents in both short and long photoperiods. The present study demonstrates the existence of a novel mechanism whereby the presen...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(91)90438-t

    authors: Nelson RJ

    更新日期:1991-11-01 00:00:00

  • Effect of amino acid supplementation to a low-protein diet on brain neurotransmitters and memory-learning ability of rats.

    abstract::The supplementation of methionine and threonine to a 10% soy protein isolate diet caused sharp decreases in the concentrations of brain tryptophan, serotonin and 5HIAA (5-hydroxyindole acetic acid) (e.g., in the hypothalamus, hippocampus, amygdala, locus coeruleus and brain stem). The serum tryptophan ratio (i.e., the...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(91)90587-e

    authors: Yokogoshi H,Nomura M

    更新日期:1991-12-01 00:00:00

  • Glucocorticoid feedback increases the sensitivity of the limbic system to stress.

    abstract::In the hypothalamus, corticotropin-releasing hormone (CRH) has a well-described role initiating the hypothalamic-pituitary-adrenal (HPA) axis response to stress. Cortisol, released from the adrenal gland, exerts negative feedback on this axis. The role of extrahypothalamic CRH in stress responses is less well known. T...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(02)00650-9

    authors: Cook CJ

    更新日期:2002-04-01 00:00:00

  • Quality and intensity of binary odor mixtures.

    abstract::The perceived intensity and quality of binary mixtures consisting of the common but dissimilar odorants, benzaldehyde (almond), eugenol (cloves), propionic acid (vinegar) and (-)-carvone (spearmint), were determined over a wide range of environmentally relevant concentrations. Consistent data were obtained from each o...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(84)90118-5

    authors: Laing DG,Panhuber H,Willcox ME,Pittman EA

    更新日期:1984-08-01 00:00:00

  • Sympathetic mediation of stress and aggressive competition: plasma catecholamines in free-living male tree lizards.

    abstract::The sympathetic nervous system and adrenal catecholaminergic tissue act to prepare an animal for "fight or flight" by release of catecholamines into synapses and plasma. However, few studies have measured plasma catecholamines in nonmammalian vertebrates and none have measured them in free-living animals. We report pl...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(96)00500-8

    authors: Matt KS,Moore MC,Knapp R,Moore IT

    更新日期:1997-05-01 00:00:00

  • Amylin decreases meal size in rats.

    abstract::Adult male rats were intraperitoneally (i.p.) injected with 1.0 microgram/kg amylin at the beginning of the dark phase in 24 h food deprived or undeprived rats, and a computerized system measured feeding behavior. In food deprived rats, amylin reduced the size of the first postdeprivation meal without affecting intram...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)02067-5

    authors: Lutz TA,Geary N,Szabady MM,Del Prete E,Scharrer E

    更新日期:1995-12-01 00:00:00

  • Long-term changes in open field behaviour following a single social defeat in rats can be reversed by sleep deprivation.

    abstract::The long-term consequences of a single social defeat on open field behaviour in rats were studied, with special emphasis on the time course of stress-induced changes. Animals were subjected to social defeat by placing them into the territory of an aggressive male conspecific for 1 h. After the defeat session experimen...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)02271-6

    authors: Meerlo P,Overkamp GJ,Benning MA,Koolhaas JM,Van den Hoofdakker RH

    更新日期:1996-07-01 00:00:00

  • Reduced sensitivity to devaluation for instrumental but not consummatory behaviors in binge eating prone rats.

    abstract::Binge eating is characterized by the consumption of a large amount of palatable food in a short period of time and is a core feature of many eating disorders. Patients with eating disorders are also known to display impairments in inhibitory control, cognition and decision-making, which may promote and maintain binge ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2019.03.005

    authors: LeMon JV,Sisk CL,Klump KL,Johnson AW

    更新日期:2019-07-01 00:00:00