Aggression in female mice: contrasting effects of amiflamine (FLA 336), a selective and reversible MAO-type A inhibitor.

Abstract:

:The effects of FLA 336 on the attack by resident groups of female mice on strange female intruders were assessed. This MAO-type A inhibitor clearly suppressed attack in treated subjects without producing major alterations in other activities but there was no clear dose-response relationship. The substance also increased attack on treated animals, an effect largely mediated via changes in the odor characteristics of the urine. The data emphasize the need for appropriate controls in studies with psychoactive compounds to distinguish direct (CNS-mediated) from indirect (mediated via changed signalling or perception) actions.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Wallian L,Brain PF,Haug M

doi

10.1016/0031-9384(93)90132-y

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

411-4

issue

2

eissn

0031-9384

issn

1873-507X

pii

0031-9384(93)90132-Y

journal_volume

54

pub_type

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