Abstract:
:In vivo voltammetry has been widely employed to monitor the effects of drugs on dopamine metabolism. In the present study, we report on the use of a newly designed assembly for implantation of carbon fiber microelectrodes for voltammetric measurements in freely moving animals. The assembly consists of an electrode holder and a fixed support (implanted stereotaxically) which is cemented to the rat skull. The working carbon fiber electrode is cemented to the electrode holder, and can be lowered into the fixed support for implantation into the brain parenchyma. This implantation assembly has been used to study the effects of tail-pinch on dopamine metabolism (extracellular DOPAC levels) in the nucleus accumbens and ventral tegmental area of the awake rat. Using this implantation assembly and 3 carbon fiber electrodes, oxidation peaks for ascorbic acid (-100 mV) and DOPAC (+ 100 mV) were recorded in both brain structures. Mild tail pressure for 7 min led to an increase in extracellular DOPAC levels in the nucleus accumbens. A smaller increase was observed in the ventral tegmental area. The DOPAC signals remained elevated for some time after removal of the stressor. This implantation assembly represents a convenient system for implanting carbon fiber electrodes in the freely moving rat, which can be employed to investigate the effects of behavioral manipulation on dopaminergic neurons at the terminal as well as at the cell body level. This microdevice could also be usefully employed for other in vivo electrochemical studies.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Louilot A,Serrano A,D'Angio Mdoi
10.1016/0031-9384(87)90357-xsubject
Has Abstractpub_date
1987-01-01 00:00:00pages
227-31issue
3eissn
0031-9384issn
1873-507Xpii
0031-9384(87)90357-Xjournal_volume
41pub_type
杂志文章abstract::Chronic stress during adolescence is related to increased prevalence of anxiety disorders and alcohol use disorders in humans. This phenotype has been consistently recapitulated in animal models with male subjects, but models using female subjects are fewer. The aim of these studies was to test the hypothesis that chr...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2017.02.010
更新日期:2017-05-01 00:00:00
abstract::Estradiol exerts an inhibitory effect on food intake via interactions with anorexigenic peptides, like cholecystokinin, that function to decrease meal size. It is currently unknown whether estradiol also interacts with orexigenic compounds implicated in the physiological control of food intake. Thus, the primary goal ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.05.002
更新日期:2006-07-30 00:00:00
abstract::The aim of the present study was to test the hypothesis that vesicular glutamate transporter 3 (VGluT3) deficiency is associated with cognitive impairments. Male VGluT3 knockout (KO) and wild type (WT) mice were exposed to a behavioral test battery covering paradigms based on spontaneous exploratory behavior and reinf...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2019.112688
更新日期:2019-12-01 00:00:00
abstract::Long-term exposure to stress and its physiological mediators, in particular cortisol, may lead to impaired telomere maintenance. In this study, we examine if greater cortisol responses to an acute stressor and/or dysregulated patterns of daily cortisol secretion are associated with shorter telomere length. Twenty-thre...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2011.11.016
更新日期:2012-04-12 00:00:00
abstract::Short- and long-term changes in the composition of dietary macronutrients [protein (P), carbohydrate (C), and fat (F)] alter neurochemistry and behavior in animals. We examined whether short-term intake of a diet rich in P, C, or F affected their anxiety response (AR). AR of Sprague-Dawley rats was measured in an elev...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(96)00135-7
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Time-restricted feeding (TRF), a key component of intermittent fasting regimens, has gained considerable attention in recent years due to reversing obesity and insulin resistance. To the best of our knowledge, here, we reported for the first time the underlying mechanistic therapeutic efficacy of TRF against...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2021.113313
更新日期:2021-03-15 00:00:00
abstract::The effects of stress on risk assessment behavior in mice were studied by examining latency to emerge from a safe compartment into a large, well-lit open field. In the first experiment different groups of mice were exposed for 1 h to tube restraint, fixed interval 2-min foot shock, or attack by an aggressive conspecif...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)02140-x
更新日期:1996-04-01 00:00:00
abstract::Whether spontaneous food intake (SFI) is controlled by infused nutrient type or its caloric content, irrespective of nutrient type, was investigated. Rats were infused for 4 days with isocaloric solutions of different nutrient type but sharing the same intermediary metabolic oxidative pathway, providing 25% of daily c...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)00028-h
更新日期:1995-07-01 00:00:00
abstract::Acute sport exercise leads to a strong stimulation of muscle tissue and a change in the organism energy demands. This study was designed to investigate the effect of oral melatonin supplementation on human physiological functions associated with acute exercise. Immune, endocrine and metabolic parameters were measured ...
journal_title:Physiology & behavior
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.physbeh.2011.12.015
更新日期:2012-03-20 00:00:00
abstract::Polychlorinated biphenyls are environmental contaminants known to affect neurobehavioral development in many laboratory studies using different animal models. Because of their bioaccumulation and long half-life they are a serious concern for our own species. The dioxin-like PCB congener 3,4,3',4'-tetrachlorobiphenyl (...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.10.022
更新日期:2005-01-31 00:00:00
abstract::Human participants judged the pungency of various concentrations of carbon dioxide presented to one nostril, the other nostril, or both (dichorhinic stimulation). Perceived magnitude grew sharply with concentration over the range explored. The combinatorial rule of bilateral integration followed the Pythagorean theore...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90025-7
更新日期:1982-08-01 00:00:00
abstract::The present report explored firstly how palatability modified the effects of energy density (ED) on short-term food intake and changes in rated appetite within a single test meal, and secondly how repeated consumption altered these relationships. Experiment 1 contrasted disguised high (HED) and low (LED) versions of a...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2005.08.019
更新日期:2005-11-15 00:00:00
abstract::Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine. These rats displayed enhanced intragroup aggression but normal muricide; gustatory neophobia and conditioned taste aversion were virtually el...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(93)90261-d
更新日期:1993-05-01 00:00:00
abstract::Subjects consumed soup (beef consomme) preloads of a fixed size containing different concentrations of monosodium L-glutamate (MSG). Effects on appetite following these preloads, and when no soup was consumed, were assessed in 3 studies. The soups supplemented with MSG were rated as more "pleasant," more "savoury" and...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90230-2
更新日期:1990-12-01 00:00:00
abstract::Exercise-related affective responses, particularly in-task, have been implicated as influencing behavioral maintenance. An extensive body of literature, primarily using aerobic modes in laboratory settings, has identified a relatively consistent inverse relationship between intensity and affect. This relationship is p...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113261
更新日期:2021-03-01 00:00:00
abstract::Using air-dilution olfactometry, we measured concentration-response functions for the odor detection of the homologous esters ethyl, butyl, hexyl, and octyl acetate. Stimuli were delivered by means of an 8-station vapor delivery device (VDD-8) specifically designed to capture odor detection performance by humans under...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2008.09.021
更新日期:2008-12-15 00:00:00
abstract::An operant chamber has been developed for studying lever-press conditioning in the green crab Carcinus maenas. In one series of experiments, animals were presented with a single bar and were reinforced with food for every bar press. Performance increased over time and high rates of responding were observed after 2 day...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90311-q
更新日期:1990-08-01 00:00:00
abstract::The circadian system is believed to be composed of a population of oscillators that couple together and generate a single rhythm. If this coupling is not strong enough, the circadian system can be dissociated into two or more groups of oscillators, and this is manifested in a dissociation of the overt rhythm into at l...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(00)00241-9
更新日期:2000-08-01 00:00:00
abstract::This is the first experimental study directed at differentiating between physiological or sensory accounts of the satiation of nondrug cravings, using chocolate craving, the most common craving in North America. At the onset of craving, chocolate cravers consumed a chocolate bar, the caloric equivalent in "white choco...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0031-9384(94)90283-6
更新日期:1994-09-01 00:00:00
abstract::The Mashona mole rat, Cryptomys darlingi, is a social, subterranean African rodent that is rarely, if ever, exposed to light, and that exhibits a regressed visual system. This study investigated locomotor activity patterns of Mashona mole rats (n=12) under different light cycles. Activity was measured using either inf...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.11.005
更新日期:2005-02-15 00:00:00
abstract::Memory and learning are impaired by imbalanced diet consumption. High-fat high-carbohydrate diet (HFCD) induces oxidative stress, which results in neuronal damage and interference with synaptic transmission; hence, a decline in cognitive function. Vitamin E is a fat soluble antioxidant that is believed to have positiv...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2013.06.011
更新日期:2013-07-02 00:00:00
abstract::GPRC6A is an amino acid-sensing receptor highly expressed in the brain and in skeletal muscle. Although recent evidence suggests that genetically engineered GPRC6A receptor knockout (KO) mice are susceptible to develop subtle endocrine and metabolic disturbances, the underlying disruptions in energy metabolism are lar...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2013.05.015
更新日期:2013-06-13 00:00:00
abstract::One of the characteristics of the current obesogenic food supply is the large availability of foods that can be ingested quickly. Controlled nutrition intervention studies have shown that the ingestion of simple energy containing beverages, which are consumed very quickly, do not lead to a lower compensatory intake of...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2012.05.008
更新日期:2012-11-05 00:00:00
abstract::Because most naturally occurring toxins taste bitter to humans, any mechanism that reduces the rate at which bitter substances are ingested and digested should be adaptive. Based on the recent discovery of T2R bitter taste receptors in the gastrointestinal tract of rodents, we asked whether intragastric (IG) infusion ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.11.029
更新日期:2008-03-18 00:00:00
abstract::Male and female spontaneously hypertensive (SHR), Wistar-Kyoto (WKY), and Sprague-Dawley (SD) rats were assessed at one of two ages (postnatal day 74 or 346) for open field locomotor activity and anxiety-related behavior in the elevated plus maze (EPM). In general, the SHR displayed the least anxiety-related behavior,...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2005.06.009
更新日期:2005-08-07 00:00:00
abstract::The present experiments were based on the rat resident-intruder paradigm and aimed at better understanding the long-term conditioning properties of this social stress model. Intruders were exposed to aggressive conspecifics residents. During 3 daily encounters, intruders were either defeated or threatened by residents...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.05.063
更新日期:2007-11-23 00:00:00
abstract::Restoration of memory by pretest reminder treatments following ECS-induced amnesia in principle could be mediated by nonassociative arousal and/or reactivation of information by the reminder stimuli. In the present research, arousal value of the reminder treatment was largely a function of the novelty of the context i...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(85)90333-6
更新日期:1985-08-01 00:00:00
abstract::Carbohydrate intake, preference, and taste thresholds may be altered in current and former cigarette smokers, which may mediate weight gain and risk for obesity in individuals who quit smoking. Attempts to model these effects in rodents have primarily used noncontingent nicotine administration. The purpose of this res...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.11.002
更新日期:2016-02-01 00:00:00
abstract::The influences of three methyl xanthines (MX) on human taste responsivity, caffeine, theophylline, and theobromine, were examined using blind control procedures. Taste responsivity in the same subjects was determined using the matching procedure described by Schiffman (Study 1) and the whole-mouth procedure described ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90347-5
更新日期:1992-09-01 00:00:00
abstract::Calorie restriction (CR) has been promoted to increase longevity. Previous studies have indicated that CR can negatively affect mood and therefore the effect of CR on mood and quality of life (QOL) becomes crucial when considering the feasibility of CR in humans. We conducted a three month clinical trial on CR (reduct...
journal_title:Physiology & behavior
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.physbeh.2011.07.007
更新日期:2011-10-24 00:00:00