Abstract：
:GPRC6A is an amino acid-sensing receptor highly expressed in the brain and in skeletal muscle. Although recent evidence suggests that genetically engineered GPRC6A receptor knockout (KO) mice are susceptible to develop subtle endocrine and metabolic disturbances, the underlying disruptions in energy metabolism are largely unexplored. Based on GPRC6A's expression pattern and ligand preferences, we hypothesize that the receptor may impact energy metabolism via regulating physical activity levels. Thus, in the present study, we exposed GPRC6A receptor KO mice and their wild-type (WT) littermates to voluntary wheel running and forced treadmill exercise. Moreover, we assessed energy expenditure in the basal state, and evaluated the effects of wheel running on food intake, body composition, and a range of exercise-induced central and peripheral biomarkers. We found that adaptation to voluntary wheel running is affected by GPRC6A, as ablation of the receptor significantly enhances wheel running in KO relative to WT mice. Both genotypes responded to voluntary exercise by increasing food intake and improving body composition to a similar degree. In conclusion, these data demonstrate that the GPRC6A receptor is involved in regulating exercise behaviour. Future studies are highly warranted to delineate the underlying molecular details and to assess if these findings hold any translational value.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Clemmensen C,Pehmøller C,Klein AB,Ratner C,Wojtaszewski JF,Bräuner-Osborne Hdoi
10.1016/j.physbeh.2013.05.015subject
Has Abstractpub_date
2013-06-13 00:00:00pages
144-51eissn
0031-9384issn
1873-507Xpii
S0031-9384(13)00156-Xjournal_volume
118pub_type
杂志文章abstract：:A longitudinal behavioral study was performed in mice exposed to the bovine brain phospholipid phosphatidylserine (BC-PS) from birth until sixty days. Examination of treated and control pups revealed no effect of the treatment on body weight nor on sensorimotor reflexes. At one and two months of age, when placed in an...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90090-q
更新日期：1990-04-01 00:00:00
abstract：:Intake of saline (NaCl) solutions and water by males of two inbred strains of mice [C57BL/6J (C57) and 129/J] were examined using 48-h, two-bottle preference tests. There was a large strain difference in saline intake: at moderate concentrations (0.075-0.150 M) C57 mice tended to reject saline relative to water, where...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90063-l
更新日期：1993-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90300-q
更新日期：1992-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)00211-m
更新日期：1995-01-01 00:00:00
abstract：:Pharmacogenetically selected apomorphine-susceptible (APO-SUS) and apomorphine-unsusceptible (APO-UNSUS) rats were trained in a discrimination learning paradigm. After the initial discrimination task was solved, reinforcement contingencies were reversed. No differences between APO-SUS and APO-UNSUS animals were found ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90278-a
更新日期：1992-08-01 00:00:00
abstract：:Acutely infected animals show a set of non-specific behavioral changes known as sickness behavior. Recent studies have shown that occurrence of sickness behavior is regulated according to a motivational perspective. Thus, the display of sickness behavior may compete with display of other behaviors. In this work, we so...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.02.011
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abstract：:The aim of this study was to investigate the impact of training experience on young horses (Equus caballus)' lateralized responses to an approaching human. The results show that the one year old untrained horses display asymmetrical responses to an approaching human, with more negative reactions (escapes, threats) whe...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2011.05.009
更新日期：2011-09-01 00:00:00
abstract：:Suckling rats were undernourished from birth by underfeeding their mothers. They were refed from 3 weeks of age. Detailed analyses were made of the walking locomotion of previously undernourished and well-fed control female rats at 10 weeks, using electronic, computer, and TV techniques. Previously undernourished rats...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90421-w
更新日期：1992-10-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00154-6
更新日期：1997-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90294-5
更新日期：1986-01-01 00:00:00
abstract：:Ethanolic extract of leaves of Morus alba L. (M. alba), known as white mulberry, was orally administered (100 mg/kg b.wt) for 8 weeks to female Wistar rats that were fed a high-cholesterol diet (HCD), to investigate the potential of M. alba leaves in attenuation of obesity, dyslipidemia, insulin resistance, and defici...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2018.12.010
更新日期：2019-03-15 00:00:00
abstract：:Isatin is an endogenous indole present in mammalian tissues and fluids. This study was designed to test the effect of both acute stress (AS) and gender on isatin's levels in rat serum, heart and brain, using a HPLC-UV detection method. Basal brain isatin levels were higher in females than in males. AS resulted in incr...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2003.11.005
更新日期：2004-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.11.011
更新日期：2005-03-16 00:00:00
abstract：:Two series of experiments were designed to investigate the effects of protein composition of the first solid food consumed by young rat pups on their subsequent protein intake after weaning. In the first series of experiments, pups were allowed access to the maternal diet between 17 and 21 days of age, then weaned to ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90015-6
更新日期：1986-01-01 00:00:00
abstract：:Djungarian and Syrian hamsters were found to exhibit robust water intake following water deprivation, and in response to hyperosmotic and hypovolumetric challenges to body fluids following injections of hypertonic NaCl and polyethylene glycol, respectively. Water intake was not stimulated following peripheral injectio...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90388-5
更新日期：1988-01-01 00:00:00
abstract：:This study examined the effects of a fungal infection on body temperature (Tb) and sleep states. Tb and sleep were recorded in male rats for 24 hr after a saline injection and 48 hr after a subcutaneous injection of live brewer's yeast, at ambient temperatures (Ta's) of 20 degrees and 30 degrees C. Peak fevers of 1.6-...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90051-0
更新日期：1988-01-01 00:00:00
abstract：:The interaction of sucrose availability and oral self-administration of amphetamine was examined in 23 male Sprague-Dawley rats. Fourteen rats were given a 0.075 mg/ml amphetamine sulfate solution as their sole source of fluid and 9 rats were given water. Feeding conditions were alternated between weeks with both gran...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90312-5
更新日期：1988-01-01 00:00:00
abstract：:KINSEY, S. G., BAILEY, M. T., SHERIDAN, J. F., PADGETT, D. A. The inflammatory response to social defeat is increased in older mice. PHYSIOL BEHAV 91(0) 000-000, 2007. Previous research indicates that repeated social defeat of mice causes increased lymphocyte trafficking to the spleen, elevated proinflammatory cytokin...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.11.003
更新日期：2008-02-27 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90302-5
更新日期：1991-04-01 00:00:00
abstract：:Sex differences exist in the regulation of energy homeostasis in response to calorie scarcity or excess. Brain-derived neurotrophic factor (BDNF) is one of the anorexigenic neuropeptides regulating energy homeostasis. Expression of Bdnf mRNA in the ventromedial nucleus of the hypothalamus (VMH) is closely associated w...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.03.028
更新日期：2014-05-10 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2014.03.012
更新日期：2014-09-01 00:00:00
abstract：:A technique for recording single unit activity in the active rat with microelectrodes is described. The microdrive used is small and light enough to be carried in a well that is chronically implanted on the head of the rat. The device permits standard microelectrodes to be lowered without rotation, a feature which red...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(77)90296-7
更新日期：1977-09-01 00:00:00
abstract：:Rabbits (Oryctolagus cuniculus), like many small mammals, have a marked postpartum estrus, and during the breeding season, are often both pregnant and lactating. We examined reproductive performance and allocation of resources by rabbit mothers with overlapping litters under presumably optimal conditions of unrestrict...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.05.011
更新日期：2004-09-30 00:00:00
abstract：:The acquisition of active avoidance response was studied in rats injected intracerebroventricularly with calcitonin (CT), parathyroid hormone (PTH) or PTH-related fragments. PTH and PTH65-84 facilitated the acquisition of shuttle-box active avoidance behavior as indicated by the number of conditioned avoidance respons...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90228-2
更新日期：1984-12-01 00:00:00
abstract：:Due to previous work where we have demonstrated attenuated febrile responses post-lipopolysaccharide (LPS) in calorie restricted (CR) rodents we aimed to explore metabolic rate and behavioral thermoregulation in these CR animals post-LPS. Male Sprague-Dawley rats fed ad libitum (AL) or restricted to 50% (CR50%) of the...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2012.06.009
更新日期：2012-12-05 00:00:00
abstract：:Diet is an environmental factor with significant potential to affect the brain and behavior in both positive and negative ways. Work in animals is necessary to understand this relationship and how it may apply to mental health in humans. One area which has been investigated extensively is whether diet, specifically a ...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2020.112965
更新日期：2020-09-01 00:00:00
abstract：:Radiations are known to cause behavioural perturbations like conditioned taste aversion (CTA), performance decrement, learning, etc., even at very low doses. The manifestation of radiation-induced behavioural degradation has not been understood well and requires further studies. Therefore, the effects of low-dose whol...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(01)00434-6
更新日期：2001-05-01 00:00:00
abstract：:Twelve Sprague-Dawley male albino rats were tested with or without combined antagonism of peripheral H1 (using 2 mg/kg dexbrompheniramine IP) and H2 (using 32 mg/kg cimetidine IP) receptors for histamine prior to (a) drinking after 2.5 mg/kg histamine SC, (b) drinking after 24-hr water deprivation, and (c) drinking du...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90385-3
更新日期：1985-05-01 00:00:00
abstract：:Mixtures of compounds can often be tasted even when all of their components are too weak to be tasted separately. Such mixtures are said to be integrative. Integration was demonstrated by mixing compounds in concentrations proportional to their separate detection thresholds and then measuring the detection threshold o...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00270-9
更新日期：1997-11-01 00:00:00
abstract：:Balb/c mice were infected with influenza virus PR8 (H1N1) by the intranasal route. At various subsequent times, brain samples were examined for their content of catecholamine and indoleamine metabolites, and plasma corticosterone was measured. Virus infection was associated with a progressive loss of body and thymus w...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90078-4
更新日期：1989-03-01 00:00:00
