Effects of calcitonin, parathyroid hormone and its related fragments on acquisition of active avoidance behavior.

Abstract:

:The acquisition of active avoidance response was studied in rats injected intracerebroventricularly with calcitonin (CT), parathyroid hormone (PTH) or PTH-related fragments. PTH and PTH65-84 facilitated the acquisition of shuttle-box active avoidance behavior as indicated by the number of conditioned avoidance responses and the percentage of animals reaching the learning criterion. PTH1-34 and PTH44-68, on the contrary, inhibited the acquisition of active avoidance behavior, while CT totally suppressed this behavior in the rat. It is possible that the opposite effects of PTH and CT on learning ability of the rat depend on a different action on calcium metabolism.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Clementi G,Drago F,Prato A,Cavaliere S,Di Benedetto A,Leone F,Scapagnini U,Rodolico G

doi

10.1016/0031-9384(84)90228-2

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

913-6

issue

6

eissn

0031-9384

issn

1873-507X

pii

0031-9384(84)90228-2

journal_volume

33

pub_type

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