Abstract：
:Analyses of the behavioral reactions of rodents to predators have greatly contributed to the understanding of defense-related human psychopathologies such as anxiety and panic.We here investigated the behavioral consequences of exposing male Wistar rats to a live cat using the elevated T-maze test of anxiety. This test allows the measurement of two defensive responses: inhibitory avoidance and escape, which in terms of pathology have been associated with generalized anxiety and panic disorders, respectively. For comparative reasons, the effects of exposure to the cat were also assessed in the elevated plus-maze. The results showed that a 5-min exposure to the cat selectively facilitated inhibitory avoidance acquisition, an anxiogenic effect, without affecting escape expression in the elevated T-maze. This was seen immediately but not 30 min after contact with the predator. This short-lived anxiogenic effect was also detected in the elevated plus-maze. Previous administration of the benzodiazepine anxiolytic diazepam (2 mg/kg) decreased the immediate avoidance response to the predator and the neophobic reaction to a dummy cat used as a control stimulus. The drug also impaired inhibitory avoidance acquisition in the elevated T-maze, indicating an anxiolytic effect, without affecting escape performance. The results indicate that the state of anxiety evoked during contact with the predator generalizes to both elevated plus- and T-mazes, impacting on defensive responses associated with generalized anxiety disorder.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Bulos EM,Pobbe RL,Zangrossi H Jrdoi
10.1016/j.physbeh.2015.04.019subject
Has Abstractpub_date
2015-07-01 00:00:00pages
28-35eissn
0031-9384issn
1873-507Xpii
S0031-9384(15)00214-0journal_volume
146pub_type
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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pub_type： 杂志文章
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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更新日期：2013-09-10 00:00:00
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pub_type： 杂志文章
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更新日期：1990-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90195-9
更新日期：1989-12-01 00:00:00
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更新日期：2012-01-18 00:00:00
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