Elevated plus-maze behavior in adult offspring of selectively bred rats.

Abstract:

:Animals sampled from the third generation (S3) of selective breeding of N:NIH strain rats based on ultrasonic vocalization (USV) rates in infancy (High, Low, and Random lines) were tested as adults on the elevated plus maze, a well-validated test of anxiety. Results showed that the Low line spent a greater percent of time in the open arms of the maze than High and Random (control) line animals, and a lower percent of time exploring from a relatively more protected position. There were no significant sex differences. The present study represents a probe into the processes at work during the early stages of selection for infant USV, and suggests that an adult measure of anxiety may be affected by selection for this infantile behavior.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Dichter GS,Brunelli SA,Hofer MA

doi

10.1016/0031-9384(95)02222-8

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

299-304

issue

1

eissn

0031-9384

issn

1873-507X

pii

0031938495022228

journal_volume

60

pub_type

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