Dose-related stimulation of feeding by systemic injections of monosodium glutamate.

Abstract:

:Monosodium glutamate (MSG) is an excitotoxin capable of both stimulating and lesioning neurons in circumventricular organs (CVOs) after systemic administration. In this study, MSG and equiosmotic concentrations of NaCl were administered subcutaneously to adult rats in order to observe the effects on food and water intake. MSG (0.5, 1, 2 and 6 g/kg), but not NaCl, stimulated feeding. The magnitude of the feeding was dose-related. After the highest dose, rats consumed 4.4 g of pelleted food. Since MSG does not cross the blood-brain barrier, we conclude that feeding was stimulated by an action of glutamate on CVOs. Doses of MSG that stimulated feeding did not alter blood glucose concentration. Neonatal MSG treatment, which is known to be more damaging to circumventricular neurons than adult treatment, greatly reduced or abolished subsequent MSG-induced stimulation of feeding in adults. Both MSG and NaCl stimulated drinking. Since the magnitude of the drinking response was similar for both solutes and was directly related to the osmotic strength of the solutions, we conclude that the drinking response after MSG was mediated by cellular dehydration.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Reddy VM,Meharg SS,Ritter S

doi

10.1016/0031-9384(86)90412-9

subject

Has Abstract

pub_date

1986-10-01 00:00:00

pages

465-9

issue

4

eissn

0031-9384

issn

1873-507X

pii

0031-9384(86)90412-9

journal_volume

38

pub_type

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