Abstract:
:The noradrenergic innervation of the forebrain by cells from the locus coeruleus (LC) was interrupted by either electrolytic lesions of the LC or 6-hydroxydopamine (6-OHDA) lesions of the dorsal noradrenergic bundle (DB). Animals so treated were then tested in a modified open field test designed to measure responsiveness to environmental novelty and also tested for food consumption in their home cages. In addition, DB lesioned animals were tested in photocell activity cages for both their initial locomotor response to the novel cages as well as their activity level after habituation. The DB lesioned animals were also tested for rates of acquisition and extinction of an operant response. The DB lesion produced no deficits in either the acquisition or the extinction of a food rewarded operant response. The DB lesion did reduce the initial amount of locomotor activity in response to introduction to the activity cages but did not alter the rate of habituation of the locomotor response nor the "basal" level of activity at the end of two hr of exposure. Neither lesion affected the amount of food eaten by 24 hr-fasted animals in their home cages during the first 15 min. When fasted prior to being given access to food in a novel open field, however, both lesions resulted in decreased food consumption and decreased amounts eaten per approach to the food pedestal. The DB lesion, but not the LC lesion, resulted in decreased rearing and grooming in this setting.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Britton DR,Ksir C,Britton KT,Young D,Koob GFdoi
10.1016/0031-9384(84)90171-9subject
Has Abstractpub_date
1984-09-01 00:00:00pages
473-8issue
3eissn
0031-9384issn
1873-507Xpii
0031-9384(84)90171-9journal_volume
33pub_type
杂志文章abstract::To partly or completely satisfy the increasing demand for insulin, pregnant rats were infused SC with human insulin (2.4 or 4.8 IU/day) from day 14 to day 20 of gestation. Cyclic control rats underwent the same procedure of 6 days of insulin-treatment. During the treatment all groups of rats were hypoglycaemic, but fo...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)00080-3
更新日期:1995-09-01 00:00:00
abstract::Rats were exposed to daily sessions of either restraint plus cold, forced exercise, or grid shock for one month and then subjected to the ulcerogenic effects of either supine restraint plus cold, or activity-stress. Chronic stress generally protected against stress ulcer but the protection depended on the degree of si...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(86)90493-2
更新日期:1986-01-01 00:00:00
abstract::Darwinian fitness reflects trade-offs between reproduction and survival. Mechanisms have evolved in small nontropical mammals and birds to maximize reproductive output during the summer when thermoregulatory demands are relatively low and food is abundant and to shunt energy to processes that presumably increase the o...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2010.01.029
更新日期:2010-04-19 00:00:00
abstract::Cardiovascular disease is the leading cause of death worldwide and hypertension is the most common risk factor for death. Although many anti-hypertensive pharmacotherapies are approved for use in the United States, rates of hypertension have increased over the past decade. This review article summarizes a presentation...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2016.01.020
更新日期:2016-08-01 00:00:00
abstract::Four experiments were conducted to determine how the characteristics of conditioned taste aversion (CTA), as described from studies conducted in the drinking and feeding contexts, applied in the grooming context. In Experiment 1, sodium saccharin was mixed with a "neutral-tasting" jelly and applied to the fur of male ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90057-9
更新日期:1982-04-01 00:00:00
abstract::Rats obtained less food than normal on a cyclic-ratio schedule during brief, 1-hr exposure to either moderate hypobaric hypoxia (BP = 435 Torr, PO2 approximately equal to 91 Torr) or to hypoxic hypoxia (BP = 750 Torr, PO2, approximately equal to 90 Torr), but not during hypobaric exposure with 36.5% oxygen (BP = 435 T...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90266-9
更新日期:1982-09-01 00:00:00
abstract::Ostracism causes social pain and is known to activate regions of the brain that are involved in the representation of physical pain. Previous research has observed that acetominophen (a common pain reliever) can reduce the pain of exclusion. The taste and consumption of glucose can also relieve physical pain, and the ...
journal_title:Physiology & behavior
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.physbeh.2013.10.032
更新日期:2014-01-30 00:00:00
abstract::Repeated delivery of fast rise-time acoustic stimuli elicit cardiac changes in humans that reflect startle, orienting, and defense responses. To test the hypothesis that fast rise-time stimuli produce these responses in the rat, we evaluated magnitude, latency, and habituation of cardiovascular responses to brief airp...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(96)00154-0
更新日期:1996-09-01 00:00:00
abstract::Male rats, fitted with indwelling gastric fistulas, were tested with either a closed fistula (normal drinking) or an open fistula (sham drinking) following either intracellular dehydration (with NaCl), extracellular dehydration (with PEG), or the combination of the two stimuli. In normal drinking tests, the combined s...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90068-f
更新日期:1990-04-01 00:00:00
abstract::Central anionic influences on dipsogenic response was studied in 54 euhydrated rats. Quantity of water consumed following third ventricular infusions of equimolar hypertonic chloride and bicarbonate solutions of sodium, potassium, calcium, and barium was compared. Control group (n = 6) was given artificial cerebrospin...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90317-9
更新日期:1987-01-01 00:00:00
abstract::There is accumulating data suggesting a neuroprotective activity of cholesterol, especially in stroke and Alzheimer's disease (AD). In the present study, a protective activity of this lipid in simulated neonatal anoxia was investigated. Rats were subjected to high cholesterol by feeding their dams with a diet enriched...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.06.009
更新日期:2004-09-30 00:00:00
abstract::The functional effects of chronic administration of 60 mg kg-1 chloroquine or quinacrine given as daily intraperitoneal injections for 84 days on normal and denervated expansor secundariorum muscles, a smooth muscle from the wing of chicks wholly innervated by noradrenergic nerves, have been investigated. Administrati...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(93)90121-u
更新日期:1993-08-01 00:00:00
abstract::Although drug-induced rotational behavior has conventionally been used for the assessment of functional asymmetry in 6-hydroxydopamine (OHDA)-lesioned rats, a pure behavioral test that can evaluate animals with dose-dependent lesions of the dopaminergic nigrostriatal system in a drug-free state may better reflect a mo...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.04.005
更新日期:2004-09-15 00:00:00
abstract::A non-rotating, chronically implanted microdrive for small animals is described. The unit can be used for recording both slow wave and single unit activity. ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(83)80011-0
更新日期:1983-11-01 00:00:00
abstract::Continuous perfusion of the granule cells in the ventral dentate gyrus with naloxone blocked the long-term potentiation (LTP) induced by high-frequency electrical stimulation of the posterolateral amygdala in freely-moving rats. This treatment also aggravated the stomach ulceration produced by cold restraint. LTP, on ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90121-h
更新日期:1992-04-01 00:00:00
abstract::Male rat sexual behavior has been intensively studied over the past 100 years, but few studies have examined how sexual behavior changes over the course of several days of interactions. In this experiment, adult male rats in the experimental group (n=12) were given daily access to estrus females for 30 min per day for...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2014.05.001
更新日期:2014-06-22 00:00:00
abstract::Four groups of Wistar rats were exposed either to saccharin + 2,4,5-T (taste-aversion group, T-A), saccharin + oil vehicle (taste-aversion control, T-A C), water + 2,4,5-T (enhanced neophobia, E-N), or water + oil (neophobia, N). Rats in the T-A group evidenced a marked aversion to saccharin in 3 consecutive preferenc...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(77)90174-3
更新日期:1977-07-01 00:00:00
abstract::The adult suprachiasmatic nuclei (SCN) express neural cell adhesion molecule (NCAM) that carries polysialic acid (PSA), a carbohydrate polymer which controls plastic cell-cell interactions in neural tissues. Expression of the three major isoforms of NCAM [180 (principal PSA carrier), 140, and 120 kDa) varies with deve...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(01)00468-1
更新日期:2001-05-01 00:00:00
abstract::The present study investigated the effects of caffeine on memory for supraspan word lists. Twelve groups of male and female college students classified as high or low impulsive were administered (PO) 0 mg/kg, 2 mg/kg or 4 mg/kg of caffeine. Subjects listened to four word lists presented at a fast rate and four at a sl...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(85)90170-2
更新日期:1985-07-01 00:00:00
abstract::The influence of endogenous opioid peptides (EOPs) on plasma luteinizing hormone (LH) levels in subordinate female highveld mole-rats (Cryptomys hottentotus pretoriae) was investigated to elucidate the physiological mechanisms responsible for inhibiting their gonadotropin-releasing hormone (GnRH) and/or LH release. Th...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.02.005
更新日期:2006-05-30 00:00:00
abstract::The effect of food texture on the development of schedule-induced polydipsia was examined in six groups of rats (n = 8), each receiving one of six grades of food granulation. A seventh group received pellets. By the end of 15 sessions of FT 60-sec food delivery, rats receiving pellets and the coarser granulations had ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(88)90202-8
更新日期:1988-01-01 00:00:00
abstract::The sham feeding preparation was used to determine whether systemic estradiol administration inhibits the intake of 0.8 M sucrose of ovariectomized rats by decreasing the potency of pregastric controls of ingestion. During real feeding, significant reductions in the sucrose intake of estradiol-treated rats appeared wi...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)00271-6
更新日期:1995-01-01 00:00:00
abstract::Intake of a saccharin-conditioned stimulus (CS) can be suppressed following pairing with an aversive agent such as lithium chloride (LiCl) or x-rays (referred to as a conditioned taste aversion or CTA), a highly rewarding sucrose solution (referred to as an anticipatory contrast effect), or a drug of abuse such as mor...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(99)00080-3
更新日期:1999-08-01 00:00:00
abstract::The obesity epidemic is a major health and economic burden facing both developed and developing countries worldwide. Interrogation of the central and peripheral mechanisms regulating ingestive behaviors have primarily focused on food intake, and in the process uncovered a detailed neuroanatomical framework controlling...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2017.10.006
更新日期:2018-06-01 00:00:00
abstract::One-19 day old rat pups were placed individually in a thermal gradient (floor temperatures 17-45 degrees C) at either 45 degrees, 30 degrees, or 20 degrees C. From the first day of life, pups placed at 45 degrees or 30 degrees C and given sufficient time (up to 2 hrs) oriented and moved along the gradient to an area ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90279-7
更新日期:1982-09-01 00:00:00
abstract::The current study examines the effects of electrolytic median raphe lesions on the feeding and drinking behaviors of rats maintained on a 23-hr food deprivation schedule. Measurement of food intake during the feeding period indicated no difference between the two groups but lesioned animals showed significantly more s...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90108-1
更新日期:1982-01-01 00:00:00
abstract::We have investigated the effects of peripherally administered pyruvate and lactate on the intake of high fat (HF) and low fat (LF) diets by a strain of rat either sensitive (Osborne-Mendel, OM) or resistant (SSB/Pl) to high fat-induced obesity. Both pyruvate and lactate inhibited the intake of HF and LF diets by OM ra...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)02109-4
更新日期:1996-03-01 00:00:00
abstract::Parents, and particularly mothers, can influence their offspring's development in non-genetic ways. Maternal effects can occur during the mothering phase as well as during the embryonic phase. Prenatal maternal effects in birds can be mediated by yolk steroid hormones that influence subsequent offspring development. S...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2011.08.009
更新日期:2012-01-18 00:00:00
abstract::Zebrafish (Danio rerio) are rapidly becoming a popular animal model for neurobehavioral and psychopharmacological research. While startle testing is a well-established assay to investigate anxiety-like behaviors in different species, screening of the startle response and its habituation in zebrafish is a new direction...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2013.10.023
更新日期:2014-01-17 00:00:00
abstract::Inbred mice of MHC-congenic strains prefer to mate with mice of different MHC types. Mate selection based on MHC-type occurs through the urinary odors specific to each MHC-congenic mouse strain. Both urine and preputial gland odors of male mice have been postulated to act as female attractants and the present study ex...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)00374-e
更新日期:1995-07-01 00:00:00