Abstract：
:In schizophrenia, critical deficits in cognitive functions appear to reflect altered neural processing in the prefrontal cortex (PFC). Given the essential role of inhibitory neurotransmission in mediating these cognitive functions, we sought to determine whether abnormalities in the inhibitory circuitry of the PFC may contribute to the cognitive deficits of schizophrenia. In situ hybridization analyses in postmortem brain tissue from subjects with schizophrenia revealed that a subset of GABA neurons in PFC layers 1-5 do not express detectable levels of the mRNAs encoding glutamate decarboxylase (GAD(67)), a synthesizing enzyme for GABA, or the GABA membrane transporter (GAT-1), which is responsible for the reuptake of GABA into the nerve terminal. Furthermore, the affected GABA neurons appear to include chandelier cells, since decreased expression of GAT-1 mRNA is associated with decreased GAT-1 protein immunoreactivity in chandelier neuron axon terminals. Finally, immunocytochemical studies revealed that decreased GAT-1 immunoreactivity in chandelier neuron axon terminals is associated with an increase in a marker of GABA(A) receptors at the postsynaptic targets of chandelier neuron axons, the axon initial segment (AIS) of pyramidal neurons. These findings suggest that schizophrenia is associated with an up-regulation of GABA(A) receptors at pyramidal neuron AIS in response to deficient GABAergic input from chandelier neurons. Selective disruptions in inhibitory neurotransmission are likely to distort aspects of pyramidal neuron function important for working memory tasks, and thus may contribute to cognitive dysfunction in schizophrenia.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Volk DW,Lewis DAdoi
10.1016/s0031-9384(02)00936-8subject
Has Abstractpub_date
2002-12-01 00:00:00pages
501-5issue
4-5eissn
0031-9384issn
1873-507Xpii
S0031938402009368journal_volume
77pub_type
杂志文章,评审abstract：:A new method for comparing the effects of small and large intestinal mechanical stimulation was developed. Isolated intestinal loops were created by the Thiry-Vella method from the lower duodenal--upper jejunal, and from the upper colonic portion of the gut, respectively. This preparation allows parallel evaluation of...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)00301-k
更新日期：1995-03-01 00:00:00
abstract：:This study evaluated the utility of the compound nerve action potential (CAP) and spinal nociceptive withdrawal (R3) reflex in identifying and quantifying peripheral afferent activity evoked by sural nerve stimulation in humans. The results of this work demonstrate that currents less than or equal to that which elicit...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90374-o
更新日期：1993-06-01 00:00:00
abstract：:Glycemic conditioning was investigated in four experiments in which insulin was administered to animals in particular stimulus contexts. Both hyperglycemic and hypoglycemic conditioned responses were obtained, with the directionality of the CR dependent upon which environmental complex was used as the CS. These bidire...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90376-7
更新日期：1984-10-01 00:00:00
abstract：:This is the first experimental study directed at differentiating between physiological or sensory accounts of the satiation of nondrug cravings, using chocolate craving, the most common craving in North America. At the onset of craving, chocolate cravers consumed a chocolate bar, the caloric equivalent in "white choco...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0031-9384(94)90283-6
更新日期：1994-09-01 00:00:00
abstract：:Dystonia musculorum (dt) mutant mice, characterized by degeneration of spinocerebellar fibers, were evaluated in a visible platform swim test. It was found that dt mutants were slower to reach the platform than normal mice. However, the number of quadrants traversed was not higher in dt mutants. It is concluded that s...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90052-h
更新日期：1993-07-01 00:00:00
abstract：:Snacking, like any dietary behavior, can be practiced in a manner that is healthful or not. The case presented in this critical review of the literature is that snacking is problematic, primarily due to its contribution to positive energy balance and promotion of overweight/obesity. There is strong evidence that snack...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2018.02.010
更新日期：2018-09-01 00:00:00
abstract：:The effects of pinealectomy on locomotor behavior responses to cold, heat or pain were assessed in freely moving rats. External cold (4 degrees C) or heat (36 degrees C) stress produced increases of locomotion (including horizontal and vertical movement, and total distance traveled), increases of number of turnings (i...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90120-1
更新日期：1994-03-01 00:00:00
abstract：:The effects of wheel deprivation on running were explored. Eight male rats, well habituated to wheels, were each deprived of wheels for periods of 0, 1, 3, and 10 h during the night (Experiment 1) and 0, 1, 3, and 10 days (Experiment 2). In Experiment 1, as wheel deprivation lengthened, wheel running in the first 24 h...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00278-9
更新日期：1999-03-01 00:00:00
abstract：:The aim of this study was to differentiate between maternal and offspring factors involved in the control of milk ingestion. Specifically, we investigated: (1) the temporal pattern of milk ingestion in fasted and non-fasted sucklings; (2) the amount of milk released as compared to that of milk available; and (3) the r...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90052-0
更新日期：1984-11-01 00:00:00
abstract：:Fluoride ingestion has been linked to changes in behavior in mice and rats, related to dose, sex of the animal, and the timing of exposure. Previous studies have shown the behavior of female rats to be most affected by postnatal fluoride exposure, and in this study we determined the effects of postnatal fluoride expos...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.02.017
更新日期：2019-07-01 00:00:00
abstract：:This study aimed to investigate long-term stability and variability of diurnal cortisol and alpha-amylase patterns. Diurnal cortisol and alpha-amylase secretion patterns were assessed on a single workday with three waves of measurement across a total time period of 24months in 189 participants. Separate hierarchical l...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.03.021
更新日期：2017-06-01 00:00:00
abstract：:Winter is an energetically stressful period for small mammals as increasing demands for thermoregulation are often coupled with shortages of food supply. In sub-tropical savannah, Hottentot golden moles (Ambysomus hottentottus longiceps) forage throughout the year and for long periods of each day. This may enable them...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.02.022
更新日期：2005-04-13 00:00:00
abstract：:Consistent individual differences in animals' responses to different stressful situations may indicate the involvement of a single behavioural and neurological mechanism across these situations. Two replicate groups of sixteen food restricted pigs were subjected to a group feeding competition test where group members ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90535-v
更新日期：1991-09-01 00:00:00
abstract：:Three techniques were compared: automated recording (A) of 2 h of feeding activities conveyed to a computer by constantly connected electronic balances, videotaping (V) of a closeup of the head of a chick during a feed-pecking session analyzed by focal sampling at reduced speed (16 times slower), strength of pecking (...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(96)00535-5
更新日期：1997-06-01 00:00:00
abstract：:Sjogren's Syndrome (SS) patients have impaired salivary gland function and an elevated frequency of oral complaints. The taste complaints are thought to be due to sensory deficits that arise in the absence of sufficient saliva to maintain taste receptors. We assessed the subjective complaints, salivary production and ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)00211-m
更新日期：1995-01-01 00:00:00
abstract：:Obese female Zucker rats have several reproductive abnormalities, including delayed puberty, abnormal estrous cyclicity, and behavioral hyporesponsiveness to ovarian steroid hormones. To ascertain whether excessive body weight per se causes these reproductive abnormalities, obese Zucker female rats were fed ad lib or ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(99)00006-2
更新日期：1999-07-01 00:00:00
abstract：:Oxytocin treatment in rats induces long-lasting antistress and growth promoting effects. This study investigated whether prolyl-leucyl-glycinamide (PLG) (the c-terminal tripeptide of oxytocin) or tocinoic acid (the ring structure of oxytocin) could induce some of these effects in male rats. For this purpose, PLG (2 or...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.08.034
更新日期：2004-12-15 00:00:00
abstract：:The green anole, Anolis carolinensis, is the most thoroughly studied North American lizard species, yet little is known about the circadian system of this species. Studies in several lizard species, including Anolis, support the hypothesis that the pineal organ is the site of a major circadian pacemaker that controls ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(00)00340-1
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:Evidence of metabolic adaptations following weight loss is available in the literature. However, the impact of different degrees of caloric restriction on a comprehensive panel including energy expenditure (EE) and intake (EI), appetite, palatability and olfactory performance remains to be investigated. Acco...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2018.11.032
更新日期：2019-02-01 00:00:00
abstract：:Oxytocin and prolactin are potential candidates for the regulation of behavioral and physiological stress responses in the brain. To investigate the neurobiological basis of individual differences in stress responses in cattle, we examined the association of behavioral and hypothalamo-pituitary-adrenal axis reactivity...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2009.11.016
更新日期：2010-03-03 00:00:00
abstract：:Sleep deprivation may lead to increased impulsivity, however, previous literature has focused on examining effects of total sleep deprivation (TSD) rather than the more common condition, partial sleep deprivation (PSD) or 'short sleep'. Moreover, it has been unclear whether PSD impacts impulse-related cognitive proces...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2016.06.003
更新日期：2016-10-01 00:00:00
abstract：:Applying high temperature cooling concepts, i.e. high temperature cooling (T(supply) is 16-20°C) HVAC systems, in the built environment allows the reduction in the use of (high quality) energy. However, application of high temperature cooling systems can result in whole body and local discomfort of the occupants. Non-...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2012.07.008
更新日期：2012-09-10 00:00:00
abstract：:Athletes' competitive level has an effect on several psychophysiological parameters during the execution of sports-related tasks. This study analyzed the acute effect of a potentiation activity (PAP), composed by 5 loaded box jumps, on specific psychological, physiological and performance-related parameters in 22 trai...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.02.018
更新日期：2019-05-15 00:00:00
abstract：:Monosodium glutamate (MSG) is an excitotoxin capable of both stimulating and lesioning neurons in circumventricular organs (CVOs) after systemic administration. In this study, MSG and equiosmotic concentrations of NaCl were administered subcutaneously to adult rats in order to observe the effects on food and water int...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90412-9
更新日期：1986-10-01 00:00:00
abstract：:The present article analyzed the dramatic increase in alcohol ingestion that is known to occur in laboratory rats subjected to food restriction. In the first experiment, we wished to know when during the day food restricted animals consume the "extra" alcohol ration. Determinations of ethanol drinking at 3-h intervals...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(99)00078-5
更新日期：1999-09-01 00:00:00
abstract：:Entrainment of circadian rhythms (CR) to the light dark cycle has been well described under controlled, experimental conditions. However, studies in rodents have reported that rhythms in the laboratory are not always reproduced under field conditions. The aim of this study was to characterise the CR of sheep maintaine...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2018.06.001
更新日期：2018-10-01 00:00:00
abstract：:The relationship among changes in thirst sensations, blood variables, and differential fluid intake in hypohydrated humans was examined. Seven subjects were hypohydrated by 0%, 3%, 5%, and 7% of their body weight on four separate trials which were systematically randomized between subjects. Hypohydration levels were a...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0031-9384(87)90212-5
更新日期：1987-01-01 00:00:00
abstract：:The taste responses to the "umami substances" such as monosodium glutamate (MSG), guanosine 5'-monophosphate (GMP) and inosine 5'-monophosphate (IMP) were recorded from the canine chorda tympani nerve. A large synergism was observed between MSG and the nucleotides in most mongrel dogs (type A dog). The extent of the s...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90197-v
更新日期：1991-05-01 00:00:00
abstract：:Pavlovian fear conditioning was employed to investigate learning during general anesthesia. Mice were given three CS-UCS presentations while anesthetized with halothane. The CS was a 10-s tone and the UCS a 0.4-mA shock delivered intramuscularly to the hindlimbs via needle electrodes. Anesthetized control groups recei...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02137-x
更新日期：1996-04-01 00:00:00
abstract：:The influence of exogenous oxytocin (OT) on maternal and infant behavior over 60 min of suckling, which followed 6 h of isolation, was investigated on Day 12 of lactation in rats. Mothers administered 1 IU of OT or saline through an indwelling atrial catheter and their litters indicated a similar nursing and suckling ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00536-2
更新日期：1998-03-01 00:00:00
