Pavlovian fear conditioning in mice anesthetized with halothane.

Abstract:

:Pavlovian fear conditioning was employed to investigate learning during general anesthesia. Mice were given three CS-UCS presentations while anesthetized with halothane. The CS was a 10-s tone and the UCS a 0.4-mA shock delivered intramuscularly to the hindlimbs via needle electrodes. Anesthetized control groups received either CS only, UCS only, or CS followed by a 3-min delayed UCS. Strength of fear conditioning was assessed by measuring duration of suppression of drinking induced by tone presentation in a test session conducted 24 h after training. Results showed that mice trained under anesthesia exhibited a significant amount of conditioned suppression relative to the anesthetized control groups. These results show that Pavlovian fear conditioning can occur under halothane anesthesia.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Pang R,Turndorf H,Quartermain D

doi

10.1016/0031-9384(95)02137-x

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

873-5

issue

4-5

eissn

0031-9384

issn

1873-507X

pii

0031-9384(95)02137-X

journal_volume

59

pub_type

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