A noninvasive strategy for identifying and quantifying innocuous and nociceptive peripheral afferent activity evoked by nerve stimulation.

Abstract:

:This study evaluated the utility of the compound nerve action potential (CAP) and spinal nociceptive withdrawal (R3) reflex in identifying and quantifying peripheral afferent activity evoked by sural nerve stimulation in humans. The results of this work demonstrate that currents less than or equal to that which elicits a just-maximal CAP can be considered purely innocuous; provide further evidence that the R3 is an objective means of identifying noxious stimulus levels; and suggest that current provides the best noninvasive quantitative estimate of afferent activity throughout the innocuous and noxious range. This work also demonstrates that some of the individual variability in the psychophysical function can be attributed to peripheral factors that affect the amount of current reaching the nerve. It is important, therefore, that these peripheral factors be considered when studying individual differences in the psychophysical function generated by electrical stimulation.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Dowman R

doi

10.1016/0031-9384(93)90374-o

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

1163-9

issue

6

eissn

0031-9384

issn

1873-507X

pii

0031-9384(93)90374-O

journal_volume

53

pub_type

杂志文章
  • Effects of repeated stress on plasma arginine levels in young and old rats.

    abstract::The effect of age and recurring stress responses on endogenous plasma arginine (ARG) concentrations were determined. Blood from catheterized young (3 months) and old (24 months) were used to ascertain the plasma concentrations of ARG under baseline conditions, during a 30-min immobilization experience and during a 3.5...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(93)90083-r

    authors: Milakofsky L,Harris N,Vogel WH

    更新日期:1993-10-01 00:00:00

  • Feeding cycles in smokers, exsmokers and nonsmokers.

    abstract::Smokers, exsmokers and nonsmokers showed 50 to 150 minute cycles of consummatory behavior (eating and drinking) that appear to reflect a biological rhythm of oral drive. Smokers and exsmokers had significantly shorter cycles, i.e., more frequent consummatory peaks, than nonsmokers. If a greater frequency of consummato...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90480-4

    authors: Green J,Tapp WN

    更新日期:1986-01-01 00:00:00

  • Prior stress and susceptibility to stress ulcer.

    abstract::Rats were exposed to daily sessions of either restraint plus cold, forced exercise, or grid shock for one month and then subjected to the ulcerogenic effects of either supine restraint plus cold, or activity-stress. Chronic stress generally protected against stress ulcer but the protection depended on the degree of si...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90493-2

    authors: Paré WP

    更新日期:1986-01-01 00:00:00

  • Carbon disulfide: a semiochemical mediating socially-induced diet choice in rats.

    abstract::Gas chromatography/mass spectrometry revealed the presence of both carbon disulfide (CS2) and carbonyl sulfide (COS) on rat breath. Behavioral experiments indicated that rats exposed to an unfamiliar diet moistened with CS2, like rats exposed to an unfamiliar diet placed on the fur of an anesthetized rat, subsequently...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(88)90285-5

    authors: Galef BG Jr,Mason JR,Preti G,Bean NJ

    更新日期:1988-01-01 00:00:00

  • Women with PTSD have lower basal salivary cortisol levels later in the day than do men with PTSD: a preliminary study.

    abstract:UNLABELLED:Acute stress responses of women are typically more reactive than that of men. Women, compared to men, may be more vulnerable to posttraumatic stress disorder (PTSD). Whether there are differences between women and men with PTSD in levels of the stress hormone, cortisol, was investigated in a pilot study. ME...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2009.06.002

    authors: Freidenberg BM,Gusmano R,Hickling EJ,Blanchard EB,Bremner JD,Frye C

    更新日期:2010-02-09 00:00:00

  • Naloxone-sensitive potentiation at granule cell synapses in the ventral dentate gyrus and stress ulcers.

    abstract::Continuous perfusion of the granule cells in the ventral dentate gyrus with naloxone blocked the long-term potentiation (LTP) induced by high-frequency electrical stimulation of the posterolateral amygdala in freely-moving rats. This treatment also aggravated the stomach ulceration produced by cold restraint. LTP, on ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(92)90121-h

    authors: Henke PG

    更新日期:1992-04-01 00:00:00

  • Recovery from activity-stress ulcer by ad lib feeding in rats.

    abstract::In order to investigate the recovery from activity-stress ulcers by ad lib-feeding and/or cessation of running, male Wistar rats were exposed to the activity-stress paradigm, and the rats that revealed hypothermia (their rectal temperature fell below 36 degrees C) were sacrificed either immediately or after several 24...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00394-6

    authors: Hirao M,Tanaka M,Emoto H,Ishii H,Yokoo H,Yoshida M,Tsuda A

    更新日期:1997-12-31 00:00:00

  • Detection of very complex taste mixtures: generous integration across constituent compounds.

    abstract::Mixtures of compounds can often be tasted even when all of their components are too weak to be tasted separately. Such mixtures are said to be integrative. Integration was demonstrated by mixing compounds in concentrations proportional to their separate detection thresholds and then measuring the detection threshold o...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)00270-9

    authors: Stevens JC

    更新日期:1997-11-01 00:00:00

  • The mechanism by which exercise modifies brain function.

    abstract::The effect of exercise on central nervous system function was investigated in relation to the mechanism of calcium-calmodulin-dependent dopamine synthesis in the brain. It is shown here through animal experiments that exercise leads to an increase in the calcium level in the brain. This in turn enhances brain dopamine...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(96)00011-x

    authors: Sutoo DE,Akiyama K

    更新日期:1996-07-01 00:00:00

  • Rhythm and blues: Influence of CLOCK T3111C on peripheral electrophysiological indicators of negative affective processing.

    abstract::Dysfunction in the circadian system has been linked to emotion regulation and mood disorders with genetic variation in clock genes as likely contributors. Here, we focused on endophenotypes of affective processing and investigated in two independent samples of healthy individuals (n1=99, n2=108) whether genotypes of a...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2020.112831

    authors: Armbruster D,Brocke B,Kirschbaum C,Witt SH,Lesch KP,Strobel A

    更新日期:2020-05-15 00:00:00

  • Meal-engendered circadian-ensuing activity in rats.

    abstract::Large meals scheduled at greater-than-circadian periods (such as T = 31 h) tend to elicit enhanced activity approximately 24 h subsequent to receipt. These studies characterized the process responsible for this meal-engendered "circadian ensuing activity" (meal CEA). Female Sprague-Dawley rats were housed in stations ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(98)00211-x

    authors: White W,Timberlake W

    更新日期:1999-01-01 00:00:00

  • Male expulsion in cooperative Mongolian gerbils (Meriones unguiculatus).

    abstract::Mongolian gerbils are territorial rodents of steppes and semideserts of Mongolia and Northern China. At least under laboratory conditions, the family life is characterized by long-term harmonious and short-term aggressive periods in which some members are expelled. The purpose of this study was to clarify which featur...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2005.08.037

    authors: Scheibler E,Weinandy R,Gattermann R

    更新日期:2006-01-30 00:00:00

  • Amylin decreases meal size in rats.

    abstract::Adult male rats were intraperitoneally (i.p.) injected with 1.0 microgram/kg amylin at the beginning of the dark phase in 24 h food deprived or undeprived rats, and a computerized system measured feeding behavior. In food deprived rats, amylin reduced the size of the first postdeprivation meal without affecting intram...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)02067-5

    authors: Lutz TA,Geary N,Szabady MM,Del Prete E,Scharrer E

    更新日期:1995-12-01 00:00:00

  • Effects of behavior and social condition on cardiovascular response to footshock stress.

    abstract::Rats were instrumented with arterial catheters and directional-pulsed Doppler flow probes for assessment of blood pressure, heart rate, and blood flow in the renal, mesenteric, and hindquarter vascular beds. Subjects were tested in an intermittent shock procedure under paired and isolated social conditions and the car...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(89)90198-4

    authors: Viken RJ,Knutson JF,Johnson AK

    更新日期:1989-12-01 00:00:00

  • Taste perception of monosodium glutamate and inosine monophosphate by 129P3/J and C57BL/6ByJ mice.

    abstract::Our previous studies have shown that in long-term two-bottle preference tests, mice from the C57BL/6ByJ (B6) inbred strain drink more monosodium glutamate (MSG) and inosine monophosphate (IMP) than mice from the 129P3/J (129) inbred strain. The goal of this study was to examine whether this variation in consumption co...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2009.07.016

    authors: Murata Y,Beauchamp GK,Bachmanov AA

    更新日期:2009-10-19 00:00:00

  • A simple design for a small fixed four-electrode brain stimulation array.

    abstract::Anatomical studies of intracranial self-stimulation (ICSS) reward in rats often use the lesion method and, therefore, require repeated behavioral testing before and after the lesion. Other anatomical studies on unlesioned rats use a moveable electrode to permit testing at a number of ICSS sites. Combining these method...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(97)88990-1

    authors: Richterich L,Stellar JR

    更新日期:1997-08-01 00:00:00

  • The effect of cocaine on rotarod performance in male C57BL/6J mice.

    abstract::There is surprisingly little research examining the effect of cocaine on motor learning. Given that changes in motor activity can confound behavioral assays of learning and memory a direct assessment of cocaine on motor learning seems warranted. The present study was conducted to examine the effect of cocaine on motor...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2013.05.027

    authors: Heyser CJ,Vishnevetsky D,Berten S

    更新日期:2013-06-13 00:00:00

  • Auditory-evoked brainstem responses in the torpid deermouse.

    abstract::This study examined auditory-evoked brainstem responses (ABR) in the deermouse (Peromyscus maniculatus) during torpor and arousal. The ABR of the euthermic deermouse consisted of five waves occurring in a time frame of 10 ms. During torpor, ABR wave I could be elicited at slow, but not fast stimulation rates indicatin...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(95)02019-5

    authors: Katbamna B,Thodi C,Senturia JB

    更新日期:1996-01-01 00:00:00

  • Fat perception is related to PROP taster status.

    abstract::Individuals who are sensitive to the bitter compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) are also more sensitive to selected bitter and sweet substances, to sharp-tasting foods, and to the trigeminal irritant capsaicin. PTC/PROP tasters have a greater density of fungiform taste papillae and it i...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(96)00608-7

    authors: Tepper BJ,Nurse RJ

    更新日期:1997-06-01 00:00:00

  • Age-induced cognitive alterations in OF1 mice.

    abstract::Female OF1 mice aged 17-18 months were compared with female OF1 mice aged 7-11 weeks for locomotor activity, pain sensitivity, and cognitive performance using the Morris water maze, passive and active avoidance, and the elevated plus-maze learning protocol. Performance of old mice was impaired compared to those of you...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(99)00003-7

    authors: Carrié I,Debray M,Bourre JM,Francès H

    更新日期:1999-06-01 00:00:00

  • Effects of thirst-inducing stimuli on consumption of ethanol solutions by golden hamsters.

    abstract::Two experiments were performed to examine the acute effects of thirst-inducing stimuli upon the intake of tap water and ethanol solutions by golden hamsters, a species which avidly consumes ethanol solutions. In Experiment 1, three groups of adult male hamsters (n = 6/group) were maintained on Purina chow and tap wate...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(90)90353-6

    authors: DiBattista D

    更新日期:1990-06-01 00:00:00

  • Pectin is not pectin: a randomized trial on the effect of different physicochemical properties of dietary fiber on appetite and energy intake.

    abstract::An increased intake of dietary fiber has been associated with reduced appetite and reduced energy intake. Research on the effects of seemingly identical classes of dietary fiber on appetite has, however, resulted in conflicting findings. The present study investigated the effects of different fiber properties, includi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.physbeh.2014.02.007

    authors: Wanders AJ,Feskens EJ,Jonathan MC,Schols HA,de Graaf C,Mars M

    更新日期:2014-04-10 00:00:00

  • Parent-child mealtime interactions associated with toddlers' refusals of novel and familiar foods.

    abstract::Parents' feeding practices have been associated with children's dietary quality and food acceptance, but previous studies have largely relied exclusively on questionnaires to assess both parent and child behavior. The current study explored the relationships between parents' reported and observed feeding practices and...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2017.03.001

    authors: Fries LR,Martin N,van der Horst K

    更新日期:2017-07-01 00:00:00

  • Estradiol interacts with gastric or postgastric food stimuli to decrease sucrose ingestion in ovariectomized rats.

    abstract::The sham feeding preparation was used to determine whether systemic estradiol administration inhibits the intake of 0.8 M sucrose of ovariectomized rats by decreasing the potency of pregastric controls of ingestion. During real feeding, significant reductions in the sucrose intake of estradiol-treated rats appeared wi...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(94)00271-6

    authors: Geary N,Trace D,Smith GP

    更新日期:1995-01-01 00:00:00

  • Dose-related stimulation of feeding by systemic injections of monosodium glutamate.

    abstract::Monosodium glutamate (MSG) is an excitotoxin capable of both stimulating and lesioning neurons in circumventricular organs (CVOs) after systemic administration. In this study, MSG and equiosmotic concentrations of NaCl were administered subcutaneously to adult rats in order to observe the effects on food and water int...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90412-9

    authors: Reddy VM,Meharg SS,Ritter S

    更新日期:1986-10-01 00:00:00

  • Adrenal role in proceptivity and receptivity induced by two modes of estradiol treatment.

    abstract::The effects of chronic estrogen treatment on the receptive and proceptive behaviors of the female rat were investigated using two modes of estrogen administration: estrogen implants and chronic estrogen injections. In addition, the potential mediating role of the adrenal was investigated. Animals were either ovariecto...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(94)90005-1

    authors: Gorzalka BB,Moe IV

    更新日期:1994-01-01 00:00:00

  • Protection against radiation-induced conditioned taste aversion by Centella asiatica.

    abstract::Radiations are known to cause behavioural perturbations like conditioned taste aversion (CTA), performance decrement, learning, etc., even at very low doses. The manifestation of radiation-induced behavioural degradation has not been understood well and requires further studies. Therefore, the effects of low-dose whol...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/s0031-9384(01)00434-6

    authors: Shobi V,Goel HC

    更新日期:2001-05-01 00:00:00

  • Food intake in the domestic fowl: effect of intrahepatic lipid and amino acid infusions.

    abstract::Five experiments were conducted to determine the effect of hepatic and jugular infusions of amino acid and lipid solutions on short-term food intake of cockerels. Neither jugular nor hepatic infusions of amino acids had any effect on food intake of Single-Comb White Leghorn (SCWL) cockerels. Lipid infusions had no eff...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(86)90327-6

    authors: Lacy MP,Van Krey HP,Skewes PA,Denbow DM

    更新日期:1986-01-01 00:00:00

  • Evaluation of prepulse inhibition and memory impairments at early stage of cirrhosis may be considered as a diagnostic index for minimal hepatic encephalopathy.

    abstract::Minimal hepatic encephalopathy (MHE), which represents the early stage of this condition, is not clinically apparent and is prevalent in up to 80% of patients. The poor outcomes of MHE encouraged us to identify more simple methods for early diagnosis of MHE. To this purpose, we evaluated the contemporary manifestation...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/j.physbeh.2017.01.033

    authors: Aghaei I,Saeedi Saravi SS,Ghotbi Ravandi S,Nozari M,Roudbari A,Dalili A,Shabani M,Dehpour AR

    更新日期:2017-05-01 00:00:00

  • Relation of emotional behaviors to urine catecholamines and cortisol.

    abstract::We examined changes of epinephrine, norepinephrine, and cortisol levels in 24-h urine accompanying emotional behavior in cats such as restlessness, threat, and quiet biting attack elicited by electrical stimulation of specific sites within the hypothalamus. Although norepinephrine remained unchanged with restlessness ...

    journal_title:Physiology & behavior

    pub_type: 杂志文章

    doi:10.1016/0031-9384(94)00233-u

    authors: Kojima K,Maki S,Hirata K,Higuchi S,Akazawa K,Tashiro N

    更新日期:1995-03-01 00:00:00