Abstract：
:Dysfunction in the circadian system has been linked to emotion regulation and mood disorders with genetic variation in clock genes as likely contributors. Here, we focused on endophenotypes of affective processing and investigated in two independent samples of healthy individuals (n1=99, n2=108) whether genotypes of a functional single nucleotide polymorphism (SNP) in the gene encoding CLOCK (CLOCK T3111C, rs1801260) differed in physiological responses to emotional stimuli. Both samples underwent an emotional startle paradigm with startle responses being measured via EMG. In the second sample, skin conductance responses as well as corrugator and zygomaticus activity were also assessed. In both samples, CLOCK T3111C was associated with overall startle responses to loud noise bursts with T/T homozygotes showing consistently more marked responses. However, in the all-female second sample, the effects of CLOCK on skin conductance responses to the same loud noise bursts depended on hormone status: similar to the startle results, in free-cycling women T/T homozygotes showed more pronounced skin conductance response (SCR) compared to C allele carriers. The opposite was true for women using combined oral contraceptives (COC). A further CLOCK × hormone status interaction effect was found for corrugator activity. In free-cycling women, T/T homozygotes presented with less corrugator activity to affective pictures compared to C allele carriers, while the opposite pattern emerged for COC users. The findings emphasize the potential role of CLOCK for affect and mood.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Armbruster D,Brocke B,Kirschbaum C,Witt SH,Lesch KP,Strobel Adoi
10.1016/j.physbeh.2020.112831subject
Has Abstractpub_date
2020-05-15 00:00:00pages
112831eissn
0031-9384issn
1873-507Xpii
S0031-9384(20)30148-7journal_volume
219pub_type
杂志文章abstract：:To identify the source of inhibitory signals from the stomach or intestine that lead to satiation, the effects of 300-g tomato soup preloads on the gastric emptying of a solid meal and on hunger and fullness ratings were examined. Subjects were nine healthy women who each ingested an egg sandwich: 1) with no soup, 2) ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90303-4
更新日期：1994-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1989-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1995-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1984-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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journal_title：Physiology & behavior
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更新日期：1992-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1982-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2008-09-03 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1991-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90010-3
更新日期：1989-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90226-5
更新日期：1987-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)00271-6
更新日期：1995-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(88)90311-3
更新日期：1988-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2009.12.017
更新日期：2010-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(80)90066-9
更新日期：1980-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.112795
更新日期：2020-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(02)00676-5
更新日期：2002-05-01 00:00:00
abstract：:Four experiments were conducted to determine the effect of parachlorophenylalanine (PCPA) on the male mating behavior of a line of chickens genetically selected for low mating frequency and to determine the effect on brain concentrations of 5-hydroxytryptamine, dopamine (DA) and norepinephrine (NE). Mating behavior wa...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90315-9
更新日期：1984-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)00312-2
更新日期：1995-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1992-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2000-09-15 00:00:00
abstract：:Acutely infected animals show a set of non-specific behavioral changes known as sickness behavior. Recent studies have shown that occurrence of sickness behavior is regulated according to a motivational perspective. Thus, the display of sickness behavior may compete with display of other behaviors. In this work, we so...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.02.011
更新日期：2006-05-30 00:00:00
abstract：:Within the catecholaminergic systems, there are contradictory findings regarding ability of estradiol to regulate expression of genes related to catecholamine biosynthesis. Several parameters important for effects of estradiol on the catecholamine (CA) related enzyme gene expression were examined in two CA regions. Ov...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2009.07.011
更新日期：2010-02-09 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1993-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2012.04.006
更新日期：2012-07-16 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(85)90410-x
更新日期：1985-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.112992
更新日期：2020-09-01 00:00:00
abstract：:Beta,beta'-iminodipropionitrile (IDPN)-induced muscle weakness in rats is a model for motorneuropathy diseases. The effects of oral administration of branched-chain amino acids on the progression of muscle weakness and muscle atrophy induced by the administration of IDPN in the drinking water, were investigated in thi...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00154-6
更新日期：1997-09-01 00:00:00
abstract：:Oxidative damage is one of the hallmarks of the aging process. The current study evaluated effects of two proprietary antioxidant-based ingredients, rosemary extract and spearmint extract containing carnosic acid and rosmarinic acid, respectively, on learning and memory in the SAMP8 mouse model of accelerated aging. T...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.08.013
更新日期：2016-10-15 00:00:00
