FMH-induced decrease in central histamine levels produces increased feeding and body weight in rats.

Abstract:

:The present study tested the long-term effects of the histamine (H) synthesis inhibitor alpha-fluoromethylhistidine (FMH) on feeding and body weight in rats. FMH (administered via 2-week osmotic minipumps) increased feeding significantly throughout the test period. Body weights were also significantly increased toward the end of the test period. Hypothalamic H assays, performed at the end of the study, confirmed that FMH-treated rats had significantly lower H levels than controls. In general, the results suggest that H activity and feeding are inversely related.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Orthen-Gambill N,Salomon M

doi

10.1016/0031-9384(92)90132-l

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

891-3

issue

4

eissn

0031-9384

issn

1873-507X

pii

0031-9384(92)90132-L

journal_volume

51

pub_type

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