Abstract：
:The aim of the present study was to test the hypothesis that vesicular glutamate transporter 3 (VGluT3) deficiency is associated with cognitive impairments. Male VGluT3 knockout (KO) and wild type (WT) mice were exposed to a behavioral test battery covering paradigms based on spontaneous exploratory behavior and reinforcement-based learning tests. Reversal learning was examined to test the cognitive flexibility. The VGluT3 KO mice clearly exhibited the ability to learn. The social recognition memory of KO mice was intact. The y-maze test revealed weaker working memory of VGluT3 KO mice. No significant learning impairments were noticed in operant conditioning or holeboard discrimination paradigm. In avoidance-based learning tests (Morris water maze and active avoidance), KO mice exhibited slightly slower learning process compared to WT mice, but not a complete learning impairment. In tests based on simple associations (operant conditioning, avoidance learning) an attenuation of cognitive flexibility was observed in KO mice. In conclusion, knocking out VGluT3 results in mild disturbances in working memory and learning flexibility. Apparently, this glutamate transporter is not a major player in learning and memory formation in general. Based on previous characteristics of VGluT3 KO mice we would have expected a stronger deficit. The observed hypolocomotion did not contribute to the mild cognitive disturbances herein reported, either.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Fazekas CL,Balázsfi D,Horváth HR,Balogh Z,Aliczki M,Puhova A,Balagova L,Chmelova M,Jezova D,Haller J,Zelena Ddoi
10.1016/j.physbeh.2019.112688subject
Has Abstractpub_date
2019-12-01 00:00:00pages
112688eissn
0031-9384issn
1873-507Xpii
S0031-9384(19)30670-5journal_volume
212pub_type
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