Abstract：
:The deer mouse presents with spontaneous stereotypic movements that resemble the repetitive behaviours of obsessive-compulsive disorder (OCD), and demonstrates a selective response to serotonin reuptake inhibitors. OCD has been linked to altered redox status and since increased dopamine signalling can promote stereotypies as well as oxidative stress, we investigated whether the severity of deer mouse stereotypy may be associated with altered dopamine turnover and cortico-striatal redox status. Deer mice were separated into high (HSB), low (LSB) and non-stereotypy (NS) groups. Frontal cortical and striatal dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), as well as superoxide dismutase (SOD) activity, reduced (GSH) and oxidised (GSSG) glutathione and glutathione redox index, were analysed as markers for regional dopamine turnover and oxidative stress, respectively. Dopamine and its metabolites and SOD activity did not differ across the stereotypy groups. Significantly reduced GSH and GSSG and increased glutathione redox index were only observed in the frontal cortex of HSB animals. Frontal cortical GSH and GSSG were inversely correlated while glutathione redox index was positively correlated with stereotypy. Deer mouse stereotypy is thus characterised by a deficient glutathione system in the frontal cortex but not striatum, and provides a therapeutic rationale for using glutathione-active antioxidants in OCD. The evidence for a primary frontal lesion has importance for future OCD research.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Güldenpfennig M,Wolmarans de W,du Preez JL,Stein DJ,Harvey BHdoi
10.1016/j.physbeh.2011.03.008subject
Has Abstractpub_date
2011-06-01 00:00:00pages
404-11issue
3-4eissn
0031-9384issn
1873-507Xpii
S0031-9384(11)00125-9journal_volume
103pub_type
杂志文章abstract：:Human locomotion, as a behavioral system, is well suited for investigating the interplay of learning with innate biological mechanisms. The present work assembled, from previous findings, a test battery of operant conditioning to modify strong ongoing electromyographic (EMG) activity of the left tibialis anterior (TA)...
journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00115-y
更新日期：1995-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.05.024
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00119-x
更新日期：1998-06-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.03.008
更新日期：2006-06-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0031-9384(85)90385-3
更新日期：1985-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2015-05-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.11.038
更新日期：2016-03-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 信件,评审
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更新日期：2000-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00270-4
更新日期：1999-03-01 00:00:00
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pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1996-10-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2004-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1982-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1994-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1998-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1995-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1977-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-01-31 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2009-09-07 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90121-h
更新日期：1992-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2004-08-01 00:00:00
