Abstract:
:The effect of norepinephrine (NE) injection into the medial preoptic area (MPOA) on plasma glucose was studied in freely moving male rats. The rats were implanted with chronic jugular catheters for blood sampling and with unilateral intracerebral cannulas placed just above the MPOA. Blood samples were taken immediately before and 5, 10, 15, and 30 min after NE injection. As early as 5 min after NE injection, plasma glucose levels rose rapidly, reaching a peak at 15 min poststimulus. The hyperglycemic response to NE injection into the MPOA was dose-related within the range of doses tested (10, 20, and 40 nmol). Previous administration of phentolamine (50 nmol), but not propranolol (100 nmol), into the MPOA blocked the hyperglycemic response to NE injection into the MPOA. The increase of plasma glucose induced by NE into the MPOA and the blockade of the hyperglycemic response to NE by phentolamine suggest the involvement of an alpha-adrenergic mechanism in MPOA-mediated hyperglycemia. On the basis of these and previous results, we propose that MPOA alpha-adrenergic synapses relay impulses activating the sympathetic outflow expressed by neurally mediated hyperglycemia.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
De Castro MG,Foscolo RB,Reis AM,Coimbra CCdoi
10.1016/s0031-9384(96)00362-9subject
Has Abstractpub_date
1997-02-01 00:00:00pages
215-20issue
2eissn
0031-9384issn
1873-507Xpii
S0031938496003629journal_volume
61pub_type
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