Abstract：
:It has been demonstrated that acute administration of lead to mice enhances brain catalase activity and ethanol-induced locomotion. These effects of lead seem to be related, since they show similar time courses and occur at similar doses. In the present study, in an attempt to further evaluate the relation between brain catalase activity and lead-induced changes in ethanol-stimulated locomotion, the interaction between lead acetate and 3-amino-1H,2,4-triazole (AT), a well-known catalase inhibitor, was assessed. In this study, lead acetate or saline was acutely injected intraperitoneally to Swiss mice at doses of 50 or 100 mg/kg 7 days before testing. On the test day, animals received an intraperitoneal injection of AT (0, 10, or 500 mg/kg). Five hours following AT treatment, ethanol (0.0 or 2.5 g/kg, ip) was injected and the animals were placed in open-field chambers, in which locomotion was measured for 10 min. Neither lead exposure nor AT administration, either alone or in combination, had any effect on spontaneous locomotor activity. AT treatment reduced ethanol-induced locomotion as well as brain catalase activity. On the other hand, ambulation and brain catalase activity were significantly increased by both doses of lead. Furthermore, AT significantly reduced the potentiation produced by lead acetate on brain catalase and on ethanol-induced locomotor activity in a dose-dependent manner. A significant correlation was found between locomotion and catalase activity across all test conditions. The results show that brain catalase activity is involved in the effects of lead acetate on ethanol-induced locomotion in mice. Thus, this study confirms the notion that brain catalase provides the molecular basis for understanding some of the mechanisms of the action of ethanol in the central nervous system.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Correa M,Sanchis-Segura C,Aragon CMdoi
10.1016/s0031-9384(01)00511-xsubject
Has Abstractpub_date
2001-07-01 00:00:00pages
641-7issue
4eissn
0031-9384issn
1873-507Xpii
S0031-9384(01)00511-Xjournal_volume
73pub_type
杂志文章abstract：:Hormones associated with pregnancy and parturition have been implicated in facilitating the onset of maternal behavior via reductions in neophobia, anxiety, and stress responsiveness. To determine whether the onset of paternal behavior has similar associations in biparental male California mice (Peromyscus californicu...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2012.05.012
更新日期：2012-08-20 00:00:00
abstract：:The aim of this study was to differentiate between maternal and offspring factors involved in the control of milk ingestion. Specifically, we investigated: (1) the temporal pattern of milk ingestion in fasted and non-fasted sucklings; (2) the amount of milk released as compared to that of milk available; and (3) the r...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90052-0
更新日期：1984-11-01 00:00:00
abstract：:Specific areas of feline central gray (CG) modulate affective aggression elicited by hypothalamic stimulation and produce analgesia, possibly mediated by enkephalins. Despite correlations between opiates and aggressive behavior suggested previously, their relationship has not been clearly demonstrated. The goal of thi...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90209-5
更新日期：1987-01-01 00:00:00
abstract：:The regulation of food and fluid intake in lactating women was examined by comparing maternal intake during lactation, 6 weeks postpartum, to intake in two groups of nonpregnant, nonlactating women. All subjects completed a questionnaire and then filled out a food-intake diary for seven consecutive days. Lactating wom...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90071-m
更新日期：1993-10-01 00:00:00
abstract：:Recent studies indicate that neonatal and adult rats are attracted to the taste of sugar as well as to starch-derived polysaccharides (e.g., Polycose). The present study investigated whether the relative preference for sweet and starchy tastes changes during the postweaning to adulthood period in male and female rats....
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90252-y
更新日期：1990-07-01 00:00:00
abstract：:Environmental conditions promote weight gain in children and adults, with early nutritional states and the availability of energy condensed/high-fat palatable diets appearing to facilitate the development of obesity. Little is known about the extent to which prenatal and postnatal dietary manipulations alter the respo...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2010.07.018
更新日期：2010-11-02 00:00:00
abstract：:Increased cardiovascular incidence in winter is partly explained by higher blood pressure due to cold exposure. Although higher salt intake induced by cold exposure has been reported in mice, the association remains unclear in humans. To investigate the association between salt intake and cold exposure in winter, a cr...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.10.015
更新日期：2015-12-01 00:00:00
abstract：:The feeding response following administration of the anti-metabolic glucose analogue, 2-deoxy-d-glucose (2DG), is conceptualized as an experimental model of glucoprivation, which may contribute to the understanding of inter-individual differences in glucose and carbohydrate intake and, ultimately, obesity. Although va...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.12.002
更新日期：2006-03-30 00:00:00
abstract：:Effects of various doses (0-250 micrograms/kg, SC) of estradiol-17 beta (E2) in a two-bottle choice conditioned taste aversion and a two-compartment conditioned place preference procedure were studied in male and female rats. Dose-dependent taste aversion and place aversion effects of E2 were established, and the cond...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(91)90427-p
更新日期：1991-11-01 00:00:00
abstract：:Non-parturient female rats were primed with oestrogen and given 5 minutes of vaginal-cervical stimulation before foster pups were introduced to them. Virgin and multiparous Wistar rats were used and half the females were ovariectomised. Half of each group was given vaginal-cervical stimulation and the other half was h...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90378-1
更新日期：1986-01-01 00:00:00
abstract：:Nootropic, antioxidant, and neuroprotective properties have been shown in a standardized ethanol extract of Ptychopetalum olacoides (POEE), a medicinal plant traditionally used by the Amazonian elderly population. It has been revealed that POEE mechanisms of action include anticholinesterase effects, and involve beta-...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.04.022
更新日期：2008-09-03 00:00:00
abstract：:To identify the source of inhibitory signals from the stomach or intestine that lead to satiation, the effects of 300-g tomato soup preloads on the gastric emptying of a solid meal and on hunger and fullness ratings were examined. Subjects were nine healthy women who each ingested an egg sandwich: 1) with no soup, 2) ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90303-4
更新日期：1994-09-01 00:00:00
abstract：:One very synthetic way to represent a night's sleep is by way of a hypnogram: a graphical representation of the sleep stages as a function of time. The hypnogram is generally quantified by a series of variables that measure the durations and latencies of the various sleep stages including wake. These variables, howeve...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90289-r
更新日期：1993-11-01 00:00:00
abstract：:Pro-inflammatory cytokines, interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha) synthesized by activated macrophages and monocytes in response to administration of lipopolysaccharide (LPS), are considered important mediators of fever and sickness behavior. We administered rat-specific antisera for...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.05.016
更新日期：2006-09-30 00:00:00
abstract：:Previous researchers have assumed that malaise-inducing drugs condition aversions to tastes more readily than to textural stimuli. The present report shows that rats given a single injection of lithium chloride after they have sampled a viscous fluid, subsequently showed greater avoidance of that fluid than did contro...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90373-a
更新日期：1992-11-01 00:00:00
abstract：:Female OF1 mice aged 17-18 months were compared with female OF1 mice aged 7-11 weeks for locomotor activity, pain sensitivity, and cognitive performance using the Morris water maze, passive and active avoidance, and the elevated plus-maze learning protocol. Performance of old mice was impaired compared to those of you...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(99)00003-7
更新日期：1999-06-01 00:00:00
abstract：:Endogenous opioid release has been linked to exercise. We investigated if opioid blockade following forced swimming, a common model of rodent exercise, influenced cerebral glucose metabolism in mice. PET scan was used to assess the uptake of Fludeoxyglucose (FDG-18), a marker of cerebral glucose metabolism in 19 regio...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.113199
更新日期：2021-01-01 00:00:00
abstract：:Pavlovian fear conditioning was employed to investigate learning during general anesthesia. Mice were given three CS-UCS presentations while anesthetized with halothane. The CS was a 10-s tone and the UCS a 0.4-mA shock delivered intramuscularly to the hindlimbs via needle electrodes. Anesthetized control groups recei...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02137-x
更新日期：1996-04-01 00:00:00
abstract：:Jumping is a simple exercise determined by several biomechanical and physiological factors. Measures of vertical jump height are common and easy to administer tests of lower limb muscle power that are carried out with several types of equipment. This study aimed to validate and address the usefulness of the combinatio...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2020.113144
更新日期：2020-12-01 00:00:00
abstract：:Lactating resident mice respond differently to male and female intruder conspecifics, showing defensive attack towards the former and offensive attack towards the latter. The effects of fluprazine (1-5 mg/kg) on this differential response pattern have been assessed. Although fluprazine increased the latencies of attac...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90020-6
更新日期：1989-09-01 00:00:00
abstract：:A causal relationship between declining nocturnal core temperature, increasing peripheral temperature, and sleep onset has been reported. The exact trigger for these thermoregulatory changes around sleep onset, however, is unknown. Our aim was to examine one possible trigger: prior knowledge of bedtime. Fourteen young...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2006.11.018
更新日期：2007-03-16 00:00:00
abstract：:Our previous studies have shown that in long-term two-bottle preference tests, mice from the C57BL/6ByJ (B6) inbred strain drink more monosodium glutamate (MSG) and inosine monophosphate (IMP) than mice from the 129P3/J (129) inbred strain. The goal of this study was to examine whether this variation in consumption co...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2009.07.016
更新日期：2009-10-19 00:00:00
abstract：:Administration of the opioid agonist, morphine (1 and 10 mg X kg-1), resulted in significant, dose-dependent increases in the ingestive responses of food-deprived slugs, Limax maximus, and in the initiation of feeding in satiated animals. These effects could be blocked by the opiate antagonist, naloxone (1 mg kg-1), w...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90045-3
更新日期：1984-11-01 00:00:00
abstract：:The aim of this work was to demonstrate the occurrence of oxidative stress during exhaustive exercise and to determine the antioxidant response. Eight voluntary male subjects participated in this study. The exercise was a cycling mountain stage (171 km) and the cyclists took a mean+/-S.E.M. time of 270+/-12 min to com...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.07.034
更新日期：2005-01-31 00:00:00
abstract：:Estradiol exerts an inhibitory effect on food intake via interactions with anorexigenic peptides, like cholecystokinin, that function to decrease meal size. It is currently unknown whether estradiol also interacts with orexigenic compounds implicated in the physiological control of food intake. Thus, the primary goal ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.05.002
更新日期：2006-07-30 00:00:00
abstract：:In this article, we report findings from behavioral and neuroendocrine experiments in rats under pharmacologically induced antipyretic conditions. Endpoints included emotional fever, body weight setpoint, and in situ corticotropin-releasing hormone mRNA (CRHmRNA) expression. Nine male Wistar rats were treated with ace...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(02)01002-8
更新日期：2003-03-01 00:00:00
abstract：:The present study has investigated the effect of exogenous cortisol on aggression in juvenile rainbow trout, along with the involvement of mineralocorticoid (MR) and glucocorticoid receptors (GR) mediating the effects of cortisol. Fish were fed pellets supplemented with cortisol, the GR antagonist mifepristone (RU486)...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2009.09.018
更新日期：2009-12-07 00:00:00
abstract：:A technique for recording single unit activity in the active rat with microelectrodes is described. The microdrive used is small and light enough to be carried in a well that is chronically implanted on the head of the rat. The device permits standard microelectrodes to be lowered without rotation, a feature which red...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(77)90296-7
更新日期：1977-09-01 00:00:00
abstract：PURPOSE:The aim of this observational study was to identify biomechanical differences, as measured by pharyngeal manometric pressure patterns, between discrete and continuous water swallowing, as well as volitionally initiated and reflexive swallowing. METHODS:Using pharyngeal manometry, swallowing-related pressures f...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.12.029
更新日期：2015-03-01 00:00:00
abstract：:Many clinical studies show that a sizeable proportion of male alcoholics are also inclined to act violently and aggressively. Given this association in humans, we asked whether a relationship exists between ethanol intake and aggressive behaviour in laboratory rats. In a first test of the hypothesis, we measured ethan...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02156-6
更新日期：1996-04-01 00:00:00
