Estradiol-induced conditioned taste aversion and place aversion in rats: sex- and dose-dependent effects.

Abstract:

:Effects of various doses (0-250 micrograms/kg, SC) of estradiol-17 beta (E2) in a two-bottle choice conditioned taste aversion and a two-compartment conditioned place preference procedure were studied in male and female rats. Dose-dependent taste aversion and place aversion effects of E2 were established, and the conditioned taste aversion procedure was found to be more sensitive in detecting aversive properties of E2 than the conditioned place preference procedure. Although aversive properties of E2 were found in both sexes, the effects were clearly more prominent in males as compared to females. From this study, it was concluded that E2 acts as an unconditioned aversive stimulus in both male and female rats capable of gaining control over different types of behavior by associative learning.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

de Beun R,Jansen E,Smeets MA,Niesing J,Slangen JL,van de Poll NE

doi

10.1016/0031-9384(91)90427-p

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

995-1000

issue

5

eissn

0031-9384

issn

1873-507X

pii

0031-9384(91)90427-P

journal_volume

50

pub_type

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