Abstract:
:Epidemiological evidence indicates that physical activity between menarche and first pregnancy is associated with a lower risk of breast cancer among women with at least 20years between these reproductive events. The mechanism by which physical activity during this interval confers protection is unknown. This study used a novel animal model to assess potentially protective effects of physical activity on tumor development in delayed parity. Thirty-six female Sprague Dawley rats received an i.p. injection of 50mg/kg N-methyl-N-nitrosourea (MNU) at 5weeks of age. Estrogen and progesterone pellets were implanted subcutaneously 1week (early parity, EP, n=8) or 4weeks (delayed parity, DP, n=11) following MNU injection. An additional group of DP rats were progressively exercise trained (Ex+DP, n=9) on a treadmill following MNU injection for 7weeks (up to 20m/min at 15% incline for 30min). We observed the greatest tumor latency and smallest tumor burden in Ex+DP animals. Ductal hyperplasia and inflammation of non-tumor bearing mammary glands were only found in DP, and we detected a significant increase in collagen for DP and Ex+DP compared to EP. Exercise induced differential gene expression of cyclin-dependent kinase-inhibitor 1C (Cdkn1c) and urokinase-plasminogen activator (Plau) in mammary tissue of Ex+DP animals compared to DP alone. While there are delayed parity-induced changes in mammary gland collagen and gene expression levels, Ex+DP animals had longer tumor latency, smaller tumor burden, and glandular tissue resistant to ductal hyperplasia. Exercise may induce protection through beneficial regulation of gene expression profiles.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Sturgeon KM,Schweitzer A,Leonard JJ,Tobias DK,Liu Y,Cespedes Feliciano E,Malik VS,Joshi A,Rosner B,De Jonghe BCdoi
10.1016/j.physbeh.2016.11.026subject
Has Abstractpub_date
2017-02-01 00:00:00pages
52-58eissn
0031-9384issn
1873-507Xpii
S0031-9384(16)30684-9journal_volume
169pub_type
杂志文章abstract::In order to study the perception of intracranial reward in the rat, a rewarding hypothalamic brain stimulation served as conditioned stimulus (CS) in an avoidance paradigm. The rate of self-stimulations behavior was used to estimate the strength of intracranial reward and reinforcement. Tests of stimulus generalizatio...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90139-1
更新日期:1982-03-01 00:00:00
abstract::Mast cells are a type of immune cell widely distributed in the body of vertebrates. Mast cells have many granules that contain several bioactive molecules such as histamine, and these molecules are released through degranulation when the mast cell receives certain stimuli. Because the number of mast cells increases du...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2019.112681
更新日期:2019-11-01 00:00:00
abstract::Compared to male secondary sexual traits, the effect of testosterone (T) on female ornaments is understudied. In particular, it is unclear whether females experience different costs of T elevation than do males and how this affects the relationship between T and ornamentation in the two sexes. I experimentally and cor...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.04.003
更新日期:2006-07-30 00:00:00
abstract::Following cholinergic denervation of the hippocampal formation, via medial septal lesions, sympathetic fibers, originating from the superior cervical ganglia, grow into the hippocampus. Previous studies have demonstrated a detrimental effect of these fibers on recovery of a spatial-learning task in male but not female...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90291-b
更新日期:1990-10-01 00:00:00
abstract::A technique for recording single unit activity in the active rat with microelectrodes is described. The microdrive used is small and light enough to be carried in a well that is chronically implanted on the head of the rat. The device permits standard microelectrodes to be lowered without rotation, a feature which red...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(77)90296-7
更新日期:1977-09-01 00:00:00
abstract::The role of Pavlovian conditioning in humans with perennial allergic rhinitis was investigated using release of tryptase from sensitised mast cells as an indicator of allergic responsiveness. Challenge with house dust mite allergen (unconditioned stimulus) was paired with a drink of novel taste and appearance (conditi...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)90066-3
更新日期:1994-05-01 00:00:00
abstract::To characterize the mechanism of the anorexia during infection, we investigated the effect of E. coli lipopolysaccharide (LPS) on feeding in rats under various conditions: LPS (125, 100, 75, and 50 micrograms/kg body weight = b. wt.) injected intraperitoneally (IP) reduced food intake by decreasing meal frequency with...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(89)90032-2
更新日期:1989-09-01 00:00:00
abstract::There is accumulating data suggesting a neuroprotective activity of cholesterol, especially in stroke and Alzheimer's disease (AD). In the present study, a protective activity of this lipid in simulated neonatal anoxia was investigated. Rats were subjected to high cholesterol by feeding their dams with a diet enriched...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.06.009
更新日期:2004-09-30 00:00:00
abstract::The effects of loratadine, a peripherally acting histamine (H1) antagonist, and methysergide, a serotonin (5-HT) antagonist, were evaluated in seven normal-weight, male research volunteers, participating in a placebo-controlled, double-blind, 17-day residential study. Participants received oral loratadine (10 or 20 mg...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章
doi:10.1016/s0031-9384(98)00046-8
更新日期:1998-05-01 00:00:00
abstract::In the developing rodent, there is a period from about days 4 to 14 when the adrenal response to stress is either minimal or non-existent. This has been designated as the stress hyporesponsive period (SHRP). Numerous experiments have demonstrated that maternal factors are critical for the regulation of the pup's hypot...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/s0031-9384(01)00496-6
更新日期:2001-06-01 00:00:00
abstract::Plasma corticosteroid circadian periodicity was determined in three groups of individual adult male rats. Categories were: post-subdiaphragmatic vagotomy, sham-operated, and controls. Blood was sampled every 4 hours over a 48-hour period with ad lib feeding and after a 13-day period on daytime (0930--1330) restriction...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90194-9
更新日期:1982-05-01 00:00:00
abstract::Preferences for sucrose, sodium chloride (NaCl), urea and hydrochloric acid (HCl) solutions (representing sweet, salty, bitter and sour stimuli) were examined in rats with bile duct ligation using 24-hr two-bottle choice tests. Preferences in bile duct ligated rats for sucrose and NaCl solutions were decreased relativ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(88)90105-9
更新日期:1988-01-01 00:00:00
abstract::The aim of this study was to analyze the behavioral and physiological reactions of guide dogs in a distressing situation which promotes attachment behaviors towards their blind owners, and to compare such reactions with those of untrained or trainee dogs. The subjects were 57 adult Labrador and Golden retriever dogs (...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.12.001
更新日期:2007-03-16 00:00:00
abstract::In Damaraland mole-rats (Fukomys damarensis), non-breeding subordinates contribute to the care of offspring born to the breeding pair in their group by carrying and retrieving young to the nest. In social mole-rats and some cooperative breeders, dominant females show unusually high testosterone levels and it has been ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2018.03.021
更新日期:2018-09-01 00:00:00
abstract::Physical restraint, like many other stressors, can block early pregnancy, but the underlying physiological mechanisms have not been established. Exogenous estrogens in minute doses will also block early pregnancy. In the present study, female rats were exposed to 5 h of restraint daily for the first 5 days after insem...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90446-9
更新日期:1992-07-01 00:00:00
abstract::Female rats have a fertile postpartum estrus, which can result in a simultaneous gestation and lactation and later in the overlapping of two different-age litters. These different physiological and contextual situations may affect the maternal behavior of lactating rats and provoke long-lasting changes in the affectiv...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2008.02.004
更新日期:2008-03-18 00:00:00
abstract::Two experiments examined the feeding behaviour and body weight changes of rats returned to a standard chow diet after prolonged periods of cafeteria feeding. In the first, both overweight (ad lib fed) and 'normal' weight (fed a restricted ration of cafeteria foods) cafeteria rats became hypophagic compared to chow-fed...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(85)90129-5
更新日期:1985-10-01 00:00:00
abstract::Prenatal stress (heat and restraint) reduced pregnancy-induced and elevated postpartum aggression in Rockland-Swiss (R-S) albino female mice. Though prenatally-stressed females were indistinguishable from control animals with respect to parental behavior during the virgin state, the former displayed slightly lower lev...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(88)90252-1
更新日期:1988-01-01 00:00:00
abstract::The effects of naltrexone on the behavior in mice were investigated by using a multi-dimensional behavioral analyser. Within 15 min following observation, naltrexone preferentially suppressed the linear locomotion at the 10 and 30 mg/kg doses. The results suggest that naltrexone selectively disrupts the linear locomot...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(85)90121-0
更新日期:1985-02-01 00:00:00
abstract::Food marketing is a major contributor to high rates of obesity and diet-related disease among children. Researchers, advocates, and policymakers have called for improvements in the nutrition quality of foods marketed to children to improve children's health. In the United States, for over 10 years, the food and bevera...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2020.113139
更新日期:2020-12-01 00:00:00
abstract::To test the hypothesis that hepatic vagal afferents mediate the satiety effect of pancreatic glucagon, we tested the effects of selective surgical and pharmacological lesions of the abdominal vagus on glucagon's potency to inhibit feeding. Surgical disconnection of only the hepatic branch of the abdominal vagus blocke...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(83)90207-x
更新日期:1983-09-01 00:00:00
abstract::This article describes pleasant IAPS pictures that elicit low-arousal rather than the high-arousal physiological responses previously reported in the literature. Thirty-two International Affective Picture System (IAPS) photographs were grouped into 4 sets of 8 photographs: highly pleasant-arousing (sexual content and ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.03.031
更新日期:2007-08-15 00:00:00
abstract::Previous studies demonstrate that 14-day-old rats reduce their emission of ultrasonic vocalizations and freeze when exposed to an unfamiliar adult male rat. This study sought to identify the stimulus characteristics of conspecific males that potentiate the display of behavioral inhibition. In Experiment 1, day 14 rats...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)90050-7
更新日期:1994-04-01 00:00:00
abstract::A model for oral drug delivery is described for diminishing bitter taste perception. This model involves the encapsulation of a bitter taste stimulus in lipid microspheres, and the subsequent incorporation of these microspheres in rapidly dissolving edible films that include both masking and flavoring agents. Stearic ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113129
更新日期:2020-11-01 00:00:00
abstract::The role of the area postrema in radiation-induced emesis and taste aversion learning and the relationship between these behaviors were studied in cats. The potential involvement of neural factors which might be independent of the area postrema was minimized by using low levels of ionizing radiation (100 rads at a dos...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(86)90189-7
更新日期:1986-01-01 00:00:00
abstract::The effects of ethanol on blood pH, PCO2, and PO2 were measured in LS and SS mice in an attempt to ascertain whether these lines of mice, which differ in CNS sensitivity to the behavioral effects of ethanol, also differ in sensitivity to physiological effects of this drug. Long-sleep (LS) female mice were injected int...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90208-6
更新日期:1982-05-01 00:00:00
abstract::Some human diseases, including obesity, Type II diabetes, and numerous cancers, are thought to be influenced by environments experienced in early life, including in utero. Maternal diet during the perinatal period may be especially important for adult offspring energy balance, potentially affecting both body compositi...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2017.06.008
更新日期:2017-10-01 00:00:00
abstract::The neuropeptide galanin is widely distributed throughout the central nervous system with multiple and diverse biological functions mediated by different receptor subtypes. In the rat, galanin-like immunoreactivity is expressed in a population of 5-hydroxytryptamine (5-HT, serotonin) neurons in the dorsal raphe with e...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2007.05.022
更新日期:2007-09-10 00:00:00
abstract::Adult ovariectomized female rats received a testosterone propionate (TP) silastic implant (day 0) and were subsequently tested for mounting behavior. The number of females displaying mounting behavior increased from day 2 (0%) to day 14 (94%) following testosterone implantation. Olfactory bulbectomy (OB) performed on ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(91)90428-q
更新日期:1991-11-01 00:00:00
abstract::Eight Nubian dairy goat does in one experiment, and eight Alpine dairy goat does in a second experiment, were randomly allotted to food-thwarted or fed groups in a crossover experimental design. Food thwarting was hypothesized to produce an emotional state analogous to frustration. After a 1-week training period durin...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90145-r
更新日期:1992-02-01 00:00:00