Verapamil and indomethacin attenuate endotoxin-induced anorexia.

Abstract:

:To characterize the mechanism of the anorexia during infection, we investigated the effect of E. coli lipopolysaccharide (LPS) on feeding in rats under various conditions: LPS (125, 100, 75, and 50 micrograms/kg body weight = b. wt.) injected intraperitoneally (IP) reduced food intake by decreasing meal frequency without affecting meal size. The Ca++-channel blocker verapamil (5 mg/kg b. wt., IP) or the antipyretic and antiphlogistic drug indomethacin (2.5 mg/kg b. wt., IP), but not combined alpha- and beta-adrenergic receptor blockade by IP phentolamine plus propranolol (500 micrograms/kg b. wt., each) attenuated the anorectic effect of LPS (125 or 100 micrograms/kg b. wt.). The results suggest that a phospholipase A2-sensitive mechanism contributes to the anorexia during injection.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Langhans W,Harlacher R,Scharrer E

doi

10.1016/0031-9384(89)90032-2

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

535-9

issue

3

eissn

0031-9384

issn

1873-507X

pii

0031-9384(89)90032-2

journal_volume

46

pub_type

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