Abstract：
:3,4-Methylenedioxymethamphetamine (MDMA) use has been associated with a decline in various aspects of mnemonic function in humans. We therefore postulated that MDMA-induced damage of serotonergic nerve terminals would alter hippocampal processing. Seven days following treatment with MDMA (2 x 20 mg/kg sc, given 12 h apart), rat spatial learning and memory were tested utilizing the Morris water maze (MWM). No statistical differences were found in MWM platform acquisition latency or pathlength between controls and MDMA-treated animals. Probe trials revealed significantly higher proximity score averages and significantly reduced preference for the target quadrant in the MDMA-treated animals. MDMA treatment resulted in significant reduction (34%) in hippocampal serotonin (5-HT) levels 14 days after initial treatment. The findings of this study demonstrate that hippocampal serotonergic lesions induced by MDMA may be ostensibly linked to a reference memory deficit in rats tested with the MWM.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Sprague JE,Preston AS,Leifheit M,Woodside Bdoi
10.1016/s0031-9384(03)00092-1subject
Has Abstractpub_date
2003-07-01 00:00:00pages
281-7issue
2eissn
0031-9384issn
1873-507Xpii
S0031938403000921journal_volume
79pub_type
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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journal_title：Physiology & behavior
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更新日期：2009-05-25 00:00:00
