Abstract：
:Previously, a hormone-simulated pregnancy (HSP), and the subsequent 'postpartum' withdrawal in estradiol has been shown to precipitate depressive-like behaviours in the forced swim test in female rats. In this study, we used the HSP and 'postpartum' withdrawal to investigate the impact on sucrose consumption, a model of anhedonia. Rats were assigned to "postpartum", "postpartum"+EB (estradiol benzoate), "postpartum"+IMI (imipramine; a tricyclic antidepressant), "postpartum"+DPN (diarylpropionitrile; an ERbeta agonist), or ovariectomized (OVX) controls and OVX+IMI treatments. All "postpartum" groups received daily hormone injections (estradiol and progesterone) over 23 days to simulate pregnancy, while IMI groups also received daily injections of imipramine. After Day 23, "postpartum" rats were withdrawn from the hormone regimen (mimicking the postpartum decrease in gonadal hormones), and then received daily injections of compounds indicated (DPN, EB, IMI). Rats were tested for consumption of, and preference for, sucrose weekly at baseline, during 'pregnancy' and on 'Postpartum' Days 2-3. During the 'postpartum' period rats in the "postpartum" group had lower sucrose consumption and preference compared to during late-'pregnancy', but no decrease in 'postpartum' consumption or preference was seen in any other groups except "postpartum"+IMI and a decrease in sucrose preference only in the postpartum+EB group from mid-'pregnancy' to 'postpartum'. The OVX +IMI group had decreased sucrose consumption relative to OVX controls, suggesting a negative effect of imipramine on sucrose consumption. Together, these results suggest an important, though complex, role for gonadal hormones in the behavioral changes accompanying this model of depression.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Green AD,Barr AM,Galea LAdoi
10.1016/j.physbeh.2009.02.020subject
Has Abstractpub_date
2009-05-25 00:00:00pages
259-65issue
2eissn
0031-9384issn
1873-507Xpii
S0031-9384(09)00077-8journal_volume
97pub_type
杂志文章abstract：:Retrochiasmatic frontolateral knife cuts (FLC) or sham operations (Sham) were performed with a Halasz-type knife. All animals were primed with estrogen plus 0.5 mg progesterone (P) and tested for lordosis both before and after surgery. Two weeks after the last test they received estradiol (E2) in Silastic capsules and...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90008-7
更新日期：1982-08-01 00:00:00
abstract：:Tempting environmental food cues and metabolic signals are important factors in appetite regulation. Food intake reduces liking of food cues that are congruent to the food eaten (sensory-specific satiety). With this study we aimed to assess effects of sensory-specific satiety on neural processing (perceptual and evalu...
journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2017-03-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.08.029
更新日期：2007-01-30 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)02182-5
更新日期：1996-04-01 00:00:00
abstract：:Angiotensins, especially angiotensin IV (Ang IV), have recently been found to be potent cognitive enhancers in rodents. However, the precise mechanisms of their memory improving effects remain unknown. In this study we tested the hypothesis that D2 dopamine receptors at least partially mediate cognitive effects of Ang...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.03.025
更新日期：2006-06-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.12.003
更新日期：2005-02-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.05.006
更新日期：2004-09-15 00:00:00
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journal_title：Physiology & behavior
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更新日期：2016-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
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更新日期：2000-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.05.011
更新日期：2006-07-30 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2012.01.008
更新日期：2012-05-15 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90330-4
更新日期：1982-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(75)90103-1
更新日期：1975-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00050-s
更新日期：1995-08-01 00:00:00
abstract：:The obesity epidemic is a major health and economic burden facing both developed and developing countries worldwide. Interrogation of the central and peripheral mechanisms regulating ingestive behaviors have primarily focused on food intake, and in the process uncovered a detailed neuroanatomical framework controlling...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2017.10.006
更新日期：2018-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2010.12.010
更新日期：2011-03-28 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90234-9
更新日期：1986-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2011.08.029
更新日期：2012-01-18 00:00:00
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pub_type： 杂志文章
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更新日期：1982-05-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90121-h
更新日期：1992-04-01 00:00:00
abstract：:Rats are nocturnal feeders. The present results show that when either the cost of procuring a meal or the cost of consuming it increases differentially in the dark relative to the light, rats shift their feeding activity to the light phase of the light/dark cycle. These results suggest that some of the same factors th...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(83)90081-1
更新日期：1983-10-01 00:00:00
abstract：:High-fat diet-feeding increases body weight and adiposity in Syrian hamsters (Mesocricetus auratus), effects due in part to decreased energy expenditure. The effects of voluntary exercise- or cold exposure-induced increases in energy expenditure were examined in fat- or chow-fed, female Syrian hamsters. In Experiment ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90075-1
更新日期：1984-01-01 00:00:00
abstract：:The goal of this study was to investigate possible relationships between different aspects of behavioural decline in aged (17 months) NMRI mice by a multivariate analysis. These mice presented defects in spatial processing both in place learning in a Morris-type water maze and in spontaneous alternation in a Y-maze, a...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90120-5
更新日期：1993-08-01 00:00:00
abstract：:The current study examined the effects of electrolytic median raphe lesions on the performance of several T-maze discrimination tasks. Raphe lesions were found to impair the reversal, but not the acquisition, of a learned position habit, but to be without effect on either the acquisition or reversal of simultaneous br...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90223-4
更新日期：1986-01-01 00:00:00
abstract：:When Norway rat litters are nursed communally, postpartum-conceived litters born asynchronously are female biased at birth. To determine if one or more mechanisms produced this sex ratio bias, we studied litters conceived at a postpartum estrus, and systematically varied the presence or absence of a litter suckling du...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)90207-0
更新日期：1994-08-01 00:00:00
abstract：:Gross and subgross anatomical observations of the penis pointed to a mechanical arrangement whereby contraction of the bulbocavernosus (BC) muscles would enhance erections of the glans penis and contraction of the ischiocavernosus (IC) muscles would enhance or produce penis flips. These functions for the muscles were ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(83)90277-9
更新日期：1983-12-01 00:00:00
abstract：:Flash visual evoked potentials were recorded from the rat to determine whether the Grass photic stimulator could generate an auditory component of the waveform. When the click associated with each lamp flash remained unmuffled, the primary response of the visual cortex (P30) was preceded by an earlier positivity with ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90292-a
更新日期：1992-08-01 00:00:00
abstract：:The imidazopyridine zolpidem has previously been shown to displace benzodiazepines from their receptors, with a preferential activity at BZ1 sites, and to exert hypnotic activity in man. Zolpidem's pharmacological profile includes anticonvulsant, antipunishment and behavioral depressant actions. However, unlike benzod...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/0031-9384(87)90359-3
更新日期：1987-01-01 00:00:00
