Abstract：
:Evaluation of the participation of different substantia nigra sites in the sensitization of resistant (R) animals to audiogenic seizures (AS), was performed after series of small (5 mC; n = 28), medium (10 mC; n = 57) and large (15 mC; 3 points of 5 mC each, n = 19) unilateral electrolytic lesions of the substantia nigra (SN) in R rats. Animals were evaluated at 5, 10, 15, and 30 days post surgery and behavior was measured by a neuroethological method. Small unilateral lesions induced AS susceptibility in 14% R animals with 3% of them displaying tonic-clonic AS. Medium sized lesions induced AS susceptibility in 50% of the animals with 18% of these exhibiting tonic-clonic seizures similar to those displayed by naturally susceptible (S) animals, but with predominance of wild running (gyri, jumping and atonic falling) contralateral to the lesioned SN. AS severity was significantly higher at day 5 postsurgery, decreasing at days 10, 15 and 30. Large unilateral lesions destroying the entire SN failed to cause tonic-clonic seizures although wild running occurred in 10% of the animals. Bilateral large SN lesions (15 mC; n = 24) did not modify AS severity in S animals, but only induced a statistically significant increase in the AS latency. The present data suggest: (i) AS severity after SN lesions is not a linear function of the lesion size; (ii) functionally different and antagonistic AS related substrates may exist in the SN; (iii) neurochemical and hodological characterization of these areas should be important for a better understanding of their role in AS.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Doretto MC,Garcia-Cairasco Ndoi
10.1016/0031-9384(95)00050-ssubject
Has Abstractpub_date
1995-08-01 00:00:00pages
273-82issue
2eissn
0031-9384issn
1873-507Xpii
0031-9384(95)00050-Sjournal_volume
58pub_type
杂志文章abstract：:The effects of wheel deprivation on running were explored. Eight male rats, well habituated to wheels, were each deprived of wheels for periods of 0, 1, 3, and 10 h during the night (Experiment 1) and 0, 1, 3, and 10 days (Experiment 2). In Experiment 1, as wheel deprivation lengthened, wheel running in the first 24 h...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00278-9
更新日期：1999-03-01 00:00:00
abstract：:To partly or completely satisfy the increasing demand for insulin, pregnant rats were infused SC with human insulin (2.4 or 4.8 IU/day) from day 14 to day 20 of gestation. Cyclic control rats underwent the same procedure of 6 days of insulin-treatment. During the treatment all groups of rats were hypoglycaemic, but fo...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00080-3
更新日期：1995-09-01 00:00:00
abstract：:Infusions of cholecystokinin (CCK) may exert their effects on appetite by inducing feelings of nausea or anxiety. In this double blind, placebo controlled crossover study, the impact of these effects on appetite were examined. Fifteen male subjects received a 20 min i.v. infusion of cholecystokinin octapeptide (CCK-8)...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0031-9384(98)00169-3
更新日期：1998-11-15 00:00:00
abstract：:The present study aimed to examine the effect of time-of-day on postural control, body temperature, and attentional capacities in 5-6 year old children. Twelve male children (5-6-year-old) were asked to maintain an upright bipedal stance on a force platform with eyes open (EO) and eyes closed (EC) at 07:00, 10:00, 14:...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.01.029
更新日期：2015-04-01 00:00:00
abstract：:Memory and learning are impaired by imbalanced diet consumption. High-fat high-carbohydrate diet (HFCD) induces oxidative stress, which results in neuronal damage and interference with synaptic transmission; hence, a decline in cognitive function. Vitamin E is a fat soluble antioxidant that is believed to have positiv...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2013.06.011
更新日期：2013-07-02 00:00:00
abstract：:The neurotoxin capsaicin has been shown to selectively interfere with unmyelinated sensory fibers, as well as leading to depletions of substance P and other peptides. Meal pattern analysis was performed both before and after treatment with capsaicin in twelve adult male Sprague-Dawley rats. Capsaicin treatment only br...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90056-4
更新日期：1987-01-01 00:00:00
abstract：:Because most naturally occurring toxins taste bitter to humans, any mechanism that reduces the rate at which bitter substances are ingested and digested should be adaptive. Based on the recent discovery of T2R bitter taste receptors in the gastrointestinal tract of rodents, we asked whether intragastric (IG) infusion ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.11.029
更新日期：2008-03-18 00:00:00
abstract：:Female rats can show mounting behavior towards isosexual or heterosexual conspecifics. The present experiments were designed to study whether the prenatal presence of male fetuses would affect display of this mounting behavior in adulthood. Therefore mounting behavior, after gonadectomy and during continuous treatment...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90167-6
更新日期：1982-06-01 00:00:00
abstract：:Groups of intact male and female Wistar rats were exposed to a standard passive avoidance procedure. The intensity of the light bulb illuminating the platform during adaptation, pre- and post-shock trials was manipulated (5, 25 or 75 W). Entrance latencies during pre-shock trials were longer for males than for females...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(86)90084-3
更新日期：1986-01-01 00:00:00
abstract：:The aim of this study was to evaluate the effects of intraspecific social exposure (socialization vs rest) and habituation factors on the levels of urinary serotonin and cortisol [corrected respectively for creatinine to give the serotonin-creatinine ratio (5-HT/Cr) and cortisol-creatinine ratio (C/Cr)] and how they f...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.03.016
更新日期：2019-07-01 00:00:00
abstract：:Mesolimbic dopamine plays a critical role in food-related reward processing and learning. The literature focuses primarily on the nucleus accumbens as the key dopaminergic target in which enhanced dopamine signaling is associated with reward. Here, we demonstrate a novel neurobiological mechanism by which dopamine tra...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.02.026
更新日期：2014-09-01 00:00:00
abstract：:Injection of clonidine or methyldopa in rats immediately after daily two-hour exposure to a complex environment (EC) reduced the increase in occipital cortical weight normally associated with such exposure in comparison with animals kept in isolation. Drug injection four hours after EC exposure had no effect. Drug ind...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(83)90053-7
更新日期：1983-01-01 00:00:00
abstract：:The relationship among testosterone (T), free testosterone (FT), bioavailable testosterone (BT) and personality were studied in a sample of 105 healthy males (26.71±9.68years old). The possible effects of age and other hormones, such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), sex hormone binding ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.06.007
更新日期：2016-10-01 00:00:00
abstract：:Disruption of attachment relations in early life is linked to greater vulnerability to depressive illness at later ages. Evidence suggests this process involves stress-induced activation of central inflammatory factors, though the specific mediators and processes involved are not known. We used a guinea pig model in w...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2018.11.040
更新日期：2019-02-01 00:00:00
abstract：:The purpose of this study was to investigate the effects of former athleticism and current activity status on static and dynamic postural balance in older adults. Fifty-six subjects participated in four study groups including former athletes, currently active (AA; n = 15; 69.1+/-4.4 years.; 77.8+/-9.8 kg), former athl...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
doi：10.1016/s0031-9384(00)00272-9
更新日期：2000-08-01 00:00:00
abstract：:We developed and validated a method to measure steroid hormones with liquid chromatography-tandem mass spectrometry (LC-MS/MS) in faecal samples of white-faced capuchins. The method includes the measurement of adrenal and gonadal hormones such as cortisol, testosterone, estrone, progesterone and a number of their faec...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2011.09.004
更新日期：2012-01-18 00:00:00
abstract：:Sexual behavior and serum levels of testosterone (T) and estradiol (E) were examined in five young and six old rhesus males (Macaca mulatta) before and after the injection of 500 and 1000 IU of HCG. The serum levels of T and E increased in both young and old males after injection of either dose of HCG. Serum levels of...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(89)90346-6
更新日期：1989-10-01 00:00:00
abstract：:In these experiments we determined whether stress influenced intake of different flavored test solutions or only those that were preferred. In a series of studies, rats or hamsters were exposed to acute (1 h) or repeated (3 h/day for 3 days) restraint stress immediately followed by access to one of four tastants (sacc...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(98)00223-6
更新日期：1999-01-01 00:00:00
abstract：:Animal shelters are an extremely stressful environment for a dog, most specifically due to social isolation and novel surroundings. The stress response of dogs housed in this environment may be alleviated through human interaction shortly after arrival. During their second day in a public animal shelter, adult stray d...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2005.12.001
更新日期：2006-03-30 00:00:00
abstract：:We previously reported that in male rats, 24 h of social housing with an associate male rat immediately following fear conditioning attenuated conditioned hyperthermia in response to an auditory conditioned stimulus. In this study, we investigated the time window and threshold of social housing where "social buffering...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2010.10.025
更新日期：2011-02-01 00:00:00
abstract：:The synthetic octapeptide of cholecystokinin (CCK-8) was infused at the rate of 67 ng/kg-minute into the jugular vein, carotid artery, portal vein, gastric branch of the splenic artery, and aortic artery both craniad and caudad to the origins of the cranial mesenteric and coeliac arteries of 39 young female pigs. Jugu...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(83)80005-5
更新日期：1983-11-01 00:00:00
abstract：:Despite some reports that aspartame (APM)-sweetened beverages may increase subjective appetite, previously we demonstrated that drinking 280 ml of an APM-sweetened soft drink (170 mg APM) had no effect on appetite, and 560 ml of the same soft drink (340 mg APM) reduced appetite. The present study examined this appetit...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0031-9384(93)90139-7
更新日期：1993-03-01 00:00:00
abstract：:The present study was designed to clarify the mechanism of adrenergic modulation of pancreatic glucagon secretion in rats under physiological conditions by 1) epinephrine infusion alone or together with adrenergic blockers and 2) administration of adrenergic agonists. Intravenous infusion of epinephrine alone (1 micro...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90303-j
更新日期：1992-06-01 00:00:00
abstract：:Influences of depression symptoms on the sweet taste threshold were investigated in healthy college students (30 males and 40 females). Depression symptoms were scored by SDS (Self-Rating Depression Scale), and anxiety levels by STAI (State- and Trait-Anxiety Inventory). Recognition thresholds for sucrose were determi...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.01.003
更新日期：2015-03-15 00:00:00
abstract：:The taste reactivity (TR) test was devised as a method to obtain behavioural data in response to gustatory stimuli in neurologically impaired rats, incapable of voluntary feeding. Sapid solutions were infused through surgically implanted intraoral cannulae. Facial and motor responses corresponded well to known hedonic...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(95)00115-y
更新日期：1995-11-01 00:00:00
abstract：:Many studies have shown that having a meal together with others increases food intake. In contrast, the effects of having a meal on interactions with others have rarely been examined. More specifically, it is unknown if having a social interaction during a meal alters how people feel, behave, and perceive others. In t...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2015.03.014
更新日期：2015-05-15 00:00:00
abstract：:Sodium deficiency reliably produces a robust intake of saline in rats, which is associated with an increased preference for sodium solutions at hypertonic concentrations that would normally be avoided. The mechanisms underlying the shift to an increased preference for sodium in the deficient state are not well underst...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2012.01.019
更新日期：2012-05-15 00:00:00
abstract：:There is a wide body of literature to suggest that sexual experience may influence androgen secretion in various species, in turn, androgens may also influence anxiety. We hypothesized that sexual experience may alter anxiety behavior and secretion of endogenous androgens. Experiment 1: anxiety behavior of rats with a...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.04.018
更新日期：2007-10-22 00:00:00
abstract：BACKGROUND:'Low-carb' diets have been suggested to be effective in body weight (BW) management. However, these diets are relatively high in protein as well. OBJECTIVE:To unravel whether body-weight loss and weight-maintenance depends on the high-protein or the 'low-carb' component of the diet. DESIGN:Body-weight (BW)...
journal_title：Physiology & behavior
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.physbeh.2012.08.004
更新日期：2012-10-10 00:00:00
abstract：:Major histocompatibility complex (MHC) genes influence urinary odors (odortypes) of mice. That volatile odorants are involved is supported by the observation that odortype identity can be detected from a distance. Furthermore, chemical analyses of urines have revealed numerous volatile odorants that differ in relative...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.10.003
更新日期：2009-01-08 00:00:00
