Alpha 2-adrenergic modulation of pancreatic glucagon secretion in rats.

Abstract:

:The present study was designed to clarify the mechanism of adrenergic modulation of pancreatic glucagon secretion in rats under physiological conditions by 1) epinephrine infusion alone or together with adrenergic blockers and 2) administration of adrenergic agonists. Intravenous infusion of epinephrine alone (1 microgram/kg/min, equal to 0.7 nmol/kg/min) caused a significant increase in glucagon secretion. Phentolamine (an alpha blocker) or yohimbine (an alpha 2 blocker) administration completely inhibited the increase of glucagon secretion caused by epinephrine infusion, but neither the administration of bunazosin (an alpha 1 blocker) nor beta blockers inhibited it. Infusion of clonidine (an alpha 2 agonist) caused significant increase of glucagon secretion even at a low dose of 0.5 nmol/kg/min, although infusion of neither an alpha 1 nor a beta 2 agonist caused it even at the high dose of 40.0 nmol/kg/min. It is concluded that the alpha 2 receptor mechanism plays the most important role in the adrenergic modulation of glucagon secretion in rats under physiological conditions.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Saito M,Saitoh T,Inoue S

doi

10.1016/0031-9384(92)90303-j

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

1165-71

issue

6

eissn

0031-9384

issn

1873-507X

pii

0031-9384(92)90303-J

journal_volume

51

pub_type

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