Abstract:
:The functional effects on chick smooth and skeletal muscle of chronic administration of 60 mg kg-1 chloroquine or quinacrine given as daily intraperitoneal injections for 70 days have been investigated. Noradrenaline and potassium chloride (KCl) contracted the normal expansor secundariorum muscle, a smooth muscle from the wing of chicks wholly innervated by noradrenergic nerves. The muscle was unresponsive to acetylcholine and histamine. Chronic administration of chloroquine or quinacrine induced supersensitivity of expansor muscles to KCl and the muscles were contracted by acetylcholine and histamine. These actions were more pronounced in quinacrine-treated chicks and could be due to direct smooth muscle sensitization that may result in postjunctional changes. The oesophagus is a smooth muscle that is predominantly under parasympathetic control. The oesophagus from chronically-treated chicks was more sensitive to acetylcholine and KCl than the control muscles. This sensitization was more marked for chloroquine than quinacrine. Chronic administration of chloroquine and quinacrine depressed skeletal muscle contractions evoked by acetylcholine and potassium chloride. These findings indicate that chronic chloroquine and quinacrine administration sensitise smooth muscle to agonist drugs but depress neuromuscular transmission.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Lot TYdoi
10.1016/0031-9384(92)90088-jsubject
Has Abstractpub_date
1992-05-01 00:00:00pages
1035-9issue
5eissn
0031-9384issn
1873-507Xpii
0031-9384(92)90088-Jjournal_volume
51pub_type
杂志文章abstract::Oxygen-enriched drinking water, which is increasingly sold worldwide, is claimed to "keep both the body and the mind healthy." However, currently there is no scientific evidence for such a statement. Therefore, we assessed the effect of 22 weeks of drinking oxygenated water on cognitive performance in healthy mice, us...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.02.007
更新日期:2007-05-16 00:00:00
abstract::Peroxisome proliferator-activated receptor alpha (PPARα) is a transcription factor that belongs to the nuclear receptor family and plays an important role in regulating gene expression associated with lipid metabolism. PPARα promotes hepatic fatty acid oxidation and ketogenesis in response to fasting. Because energy m...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2019.112760
更新日期:2020-02-01 00:00:00
abstract::Psychological stressors are known to increase core body temperature (T(c)) in laboratory animals. Such single stress-induced hyperthermic responses are typically monophasic, as T(c) returns to baseline within several hours. However, studies on the effects of repeated psychological stress on T(c) are limited. Therefore...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2010.04.027
更新日期:2010-08-04 00:00:00
abstract::Analyses of the behavioral reactions of rodents to predators have greatly contributed to the understanding of defense-related human psychopathologies such as anxiety and panic.We here investigated the behavioral consequences of exposing male Wistar rats to a live cat using the elevated T-maze test of anxiety. This tes...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.04.019
更新日期:2015-07-01 00:00:00
abstract::Sheep and goats differ in diet selection, which may reflect different abilities to deal with the ingestion of plant secondary metabolites. Although saliva provides a basis for immediate oral information via sensory cues and also a mechanism for detoxification, our understanding of the role of saliva in the pre-gastric...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2009.07.002
更新日期:2009-10-19 00:00:00
abstract::The plasma corticosterone levels of rats were examined prior to their morning meal on Days 1, 7 and 20 of a regimen of 1 hr access daily to food mash and water. The relationship between external cues and meal provision was varied by feeding some groups immediately upon room entry each morning, and others with a variab...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90097-0
更新日期:1984-08-01 00:00:00
abstract::The 24-hour sleep-wake cycle of untreated, normal rats and of capsaicin-treated rats was continuously recorded by telemetry. Recordings were made on two baseline days at 22 degrees C, two days at 29 degrees C, and two final days at 22 degrees C. In untreated animals the daily amount of waking was reduced by the elevat...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(83)90148-8
更新日期:1983-03-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2014.04.030
更新日期:2014-05-28 00:00:00
abstract:OBJECTIVE:Electroacupuncture (EA) as well as moxibustion stimulation has been reported to produce an excitatory effect on the gastrointestinal motility of the rat. Serotonergic neurons of the mioenteric and submucous plexus are major participants in the gastrointestinal physiology. Here, we compared the outcomes of the...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.07.003
更新日期:2004-10-15 00:00:00
abstract::Three experiments examined the hypothesis that social isolation of weanling rats potentiates hedonic processes by examining the consumption of sucrose solutions. In the first experiment no differences in consumption were found between socially reared rats and isolation-reared rats allowed to consume sucrose in a famil...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00116-9
更新日期:1997-08-01 00:00:00
abstract::The sensory properties of foods and beverages are primary determinants of food choice. Some flavor components have an inherent hedonic valence that influences ingestive behavior. However, these hedonic impressions may be modified and others newly formed through their association with the post-ingestive consequences of...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2011.10.028
更新日期:2012-11-05 00:00:00
abstract::Obese female Zucker rats have several reproductive abnormalities, including delayed puberty, abnormal estrous cyclicity, and behavioral hyporesponsiveness to ovarian steroid hormones. To ascertain whether excessive body weight per se causes these reproductive abnormalities, obese Zucker female rats were fed ad lib or ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(99)00006-2
更新日期:1999-07-01 00:00:00
abstract::The effect of infantile handling stimulation on exploratory and emotional behavior of Roman high- and low-avoidance (RHA/Verh and RLA/Verh) weanling rats was investigated. Postnatally handled and nonhandled, 4-week-old males and females from both psychogenetically selected lines were exposed to a hexagonal tunnel maze...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(91)90546-z
更新日期:1991-09-01 00:00:00
abstract::Prenatal stress (heat and restraint) reduced pregnancy-induced and elevated postpartum aggression in Rockland-Swiss (R-S) albino female mice. Though prenatally-stressed females were indistinguishable from control animals with respect to parental behavior during the virgin state, the former displayed slightly lower lev...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(88)90252-1
更新日期:1988-01-01 00:00:00
abstract::Earlier studies had indicated the possibility of the involvement of the alpha(1) adrenergic receptors on the medial preoptic (mPOA) neurons in hypnogenesis. Microinjection of alpha1 agonist methoxamine (0.05 microg) into the mPOA of the rats, maintained at an ambient temperature (Tamb) of 24 degrees C, did not produce...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2005.02.013
更新日期:2005-03-31 00:00:00
abstract::Studied were isolation induced effects in guinea pigs. Males (CM) living in two colonies (12 males, 12 females, each) were compared to males (IM) born in the colonies and kept isolated from their 2nd month of age. The findings were: At 19 months of age CM showed higher testosterone and cortisol titers, higher adrenal ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(86)90129-0
更新日期:1986-01-01 00:00:00
abstract::Pigeons were allowed to feed for 1 h either 2 h after lights on (morning pulse) or 3 h before lights off (evening pulse). Body temperature was measured radiotelemetrically. Faecal excretion, as an index of rate of digestion, was measured using load cells. At 22 degrees C, faecal excretion peaked just after lights-on i...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(03)00031-3
更新日期:2003-03-01 00:00:00
abstract::Young adult rats housed in the activity-wheel cages and fed only 1 hr daily, have ulcers in the glandular stomach and reveal immunodeficiency. The present study was attempted to investigate how to separate the ulceration and immunodeficiency in order to utilize the activity-stress (A-S) model as an animal model of the...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(83)90174-9
更新日期:1983-05-01 00:00:00
abstract::Previous studies have found that adolescent social isolation of rats can lead to an increased anxiety state during adulthood, while chronic anxiety states are associated with dysregulated local GABAergic inhibition within the basolateral amygdala (BL). Therefore, we investigated the effects of post-weaning social isol...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2012.05.007
更新日期:2012-12-05 00:00:00
abstract::Obesity is a world-wide problem, and a risk factor for cardiovascular disease, diabetes, cancer and other diseases. It is well established that sex differences influence fat storage. Males and females exhibit differences in anatomical fat distribution, utilization of fat stores, levels of adipose tissue-derived hormon...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/j.physbeh.2017.02.040
更新日期:2017-07-01 00:00:00
abstract::Cardiovascular responses to moderate steady-state exercise were studied in Type A and Type B males and females. Eighteen men and 17 women, ages 20 to 40 years, were chosen for Type A (males = 10, females = 10) and Type B (males = 8, females = 7) groups by means of the Jenkins Activity Survey (JAS). Subjects exercised ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(96)00214-4
更新日期:1996-10-01 00:00:00
abstract::A protocol suited to the investigations of odor-taste interactions in a functional magnetic resonance imaging (fMRI) scanner is described and results that confirm the validity of that protocol are presented. Stimuli were dissolved in water and presented to the mouth of the participant through plastic syringes and plas...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章
doi:10.1016/j.physbeh.2003.12.018
更新日期:2004-05-01 00:00:00
abstract::Oral cavity edge perception acuity relative to the fingertip has previously been evaluated by the utilization of cognitively-loaded, stereognostic methods. However, with the lack of connection of the tongue to the visual association cortex, there is concern the superior acuity of the fingertip may be attributable to t...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113035
更新日期:2020-10-01 00:00:00
abstract::Temperature is known to impact taste perception, but its reported effect on sweet taste perception in humans is inconsistent. Here, we assess whether thermal taste phenotype alters the temperature modulation of the brains' response to sweet samples and sweet taste perception. Participants (n = 24 balanced for thermal ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2020.113266
更新日期:2021-03-01 00:00:00
abstract::Previous winning experience increases the probability of winning a subsequent contest. However, it is not clear whether winning probability is affected only by the outcome of the contest (winning or losing) or whether fighting experience itself is also sufficient to induce this effect. We investigated this question in...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2011.08.029
更新日期:2012-01-18 00:00:00
abstract::One group of male rats was reared continuously in small, stable colonies of three animals each during a ten-week period beginning when they were 46 days old. A second group of animals was also reared in small groups of three animals each but membership within these colonies was randomly changed at weekly intervals. Th...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90373-1
更新日期:1984-10-01 00:00:00
abstract::This paper describes a "stretching response" which occurs in some female laboratory rats during the course of mating. It is most obviously characterized by an indentation of the abdominal wall and tonic limb and pelvic movements, which occur in irregularly spaced pulses of variable duration. The response was not seen ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(80)90044-x
更新日期:1980-06-01 00:00:00
abstract::Pro-inflammatory cytokines, interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha) synthesized by activated macrophages and monocytes in response to administration of lipopolysaccharide (LPS), are considered important mediators of fever and sickness behavior. We administered rat-specific antisera for...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.05.016
更新日期:2006-09-30 00:00:00
abstract::In nature the degu has been observed to deposit and to investigate scents. This study employed a captive group of these animals to investigate their responses to conspecific urinary marks in a neutral arena. Both sex classes served as subjects. They were presented with urine obtained from males, from females and a sal...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(85)90027-7
更新日期:1985-06-01 00:00:00
abstract::Ultrasonic imaging was used to quantify oral movements made during the oral processing of foods while subjects assessed the intensity of the sensory attributes, thick, creamy, sweet and bitter. A series of four stimuli were prepared with high and low viscosities and high and low sweetness. Over five sessions, subjects...
journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章
doi:10.1016/j.physbeh.2006.05.021
更新日期:2006-08-30 00:00:00