Sex differences in obesity: X chromosome dosage as a risk factor for increased food intake, adiposity and co-morbidities.

Abstract:

:Obesity is a world-wide problem, and a risk factor for cardiovascular disease, diabetes, cancer and other diseases. It is well established that sex differences influence fat storage. Males and females exhibit differences in anatomical fat distribution, utilization of fat stores, levels of adipose tissue-derived hormones, and obesity co-morbidities. The basis for these sex differences may be parsed into the effects of male vs. female gonadal hormones and the effects of XX vs. XY chromosome complement. Studies employing mouse models that allow the distinction of gonadal from chromosomal effects have revealed that X chromosome dosage influences food intake, which in turn affects adiposity and the occurrence of adverse metabolic conditions such as hyperinsulinemia, hyperlipidemia, and fatty liver. The identification of X chromosome dosage as a player in the behavior and physiology related to obesity suggests novel molecular mechanisms that may underlie sex differences in obesity and metabolism.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Reue K

doi

10.1016/j.physbeh.2017.02.040

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

174-182

eissn

0031-9384

issn

1873-507X

pii

S0031-9384(17)30005-7

journal_volume

176

pub_type

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